Results 81 to 90 of about 13,672,018 (258)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The Effect of Combined Training and L-arginine Supplementation on Insulin Resistance, Body Composition, and IL-6 Levels in Obese Men [PDF]

مجله دانشگاه علوم پزشکی خراسان شمالی
Introduction: Despite the anti-inflammatory effects of exercise training and L-arginine ingestion, the combined impact of these two interventions on various inflammatory mediators is still unknown.
Hamid Bahrami, Mandana Gholami, Bahram Abedi   +2 more
doaj  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Amidine-Based Compounds Affecting l-Arginine Metabolism

, 2016
The l-Arg availability or the production of end products can be altered in different pathological conditions, resulting in profound physiologic consequences, with disruption of normal homeostasis in the human body.
Marialuigia Fantacuzzi, FANTACUZZI, MARIALUIGIA, Cristina Maccallini, AMOROSO, Rosa, MACCALLINI, Cristina, Rosa Amoroso   +5 more
core   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Effect of L-arginine on the growth of Plasmodium falciparum and immune modulation of host cells

Journal of Vector Borne Diseases, 2017
Background & objectives: Malaria is a life-threatening disease caused by Plasmodium parasites. The life-cycle of Plasmodium species involves several stages both in mosquito and the vertebrate host. In the erythrocytic stage, Plasmodium resides inside the
Vikky Awasthi, Rubika Chauhan, Debprasad Chattopadhyay, Jyoti Das   +3 more
doaj  

Nonspecific blockade of vascular free radical signals by methylated arginine analogues

Brazilian Journal of Medical and Biological Research, 1998
Methylated arginine analogues are often used as probes of the effect of nitric oxide; however, their specificity is unclear and seems to be frequently overestimated.
M.A. Pedro, O. Augusto, H.V. Barbeiro, M.H.C. Carvalho, P.L. da-Luz, F.R.M. Laurindo   +5 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Studies on Arginine Peptides. II. Synthesis of L-Arginyl-L-arginine and other N-Terminal Arginine Dipeptides

, 1959
Dicarbobenzoxy-L-arginine and tricarbobenzoxy-L-arginine have been utilized for the preparation of a variety of dipeptides containing an N-terniinal arginine residue.
Zervas, L., Otani, T.T., Greenstein, J.P., Winitz, M.   +3 more
core   +1 more source

Cooperative effects of urea and L-arginine on protein refolding

, 2009
The use of low concentrations of urea, guanidinium chloride or arginine has been reported in the literature to increase protein refolding and yield of active proteins by suppressing aggregate formation. However, no studies have yet examined whether these
Wang, Yinjue, Ding, Hong, Su, ZG, Li, Xiunan, Ma, Guanghui, Su, Zhiguo, Liu, Yongdong, Chen, Jing   +7 more
core   +1 more source