Results 171 to 180 of about 22,679 (205)

Immunosuppression by L-Asparaginase

Nature, 1970
L-ASPAHAGINASE, an enzyme which occurs in the serum of certain rodents and is produced by various microorganisms, catalyses the hydrolysis of asparagine to L-aspartic acid and ammonia. It has been found useful in the treatment of acute lymphoblastic leukaemia and in occasional cases of other types of neoplasm in man1.
openaire   +2 more sources

L-Asparaginase Purification

Separation & Purification Reviews, 2016
L-asparaginase (L-ASNase) is the gold standard enzyme used to treat acute lymphoblastic leukemia. This disease primarily affects children; however, treatment increases survival from 20% to 90%. As a bioproduct, it is obtained via a biotechnological process and its purification usually consists of several steps that account for up to 80% of the total ...
Louise L. Tundisi, Diego F. Coêlho, Beatriz Zanchetta, Patricia Moriel, Adalberto Pessoa, Elias B. Tambourgi, Edgar Silveira, Priscila G. Mazzola   +7 more
openaire   +1 more source

Immunosuppression by L-Asparaginase

Nature, 1969
IN 1953 Kidd1 discovered that the growth of certain murine lymphomas is inhibited by the administration of guinea-pig serum. Broome2 found the suppressive factor to be L-asparaginase, an enzyme widely distributed in nature but present in serum only in guinea-pigs and in rodents of the superfamily Cavioidea3.
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L-ASPARAGINASE AND BLASTOGENESIS

The Lancet, 1969
G, Astaldi, G R, Burgio, G, Biscatti, A, Astaldi, L, Ferfoglia   +4 more
  +12 more sources

L-Asparaginase

Annual Review of Medicine, 1970
R L, Capizzi, J R, Bertino, R E, Handschumacher   +2 more
  +7 more sources

l-Asparaginase (Elspar/Erwinase)

2015
Antineoplastic therapy, mainly for acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma in adult and pediatric patients.
Rania Hito, Ronil V. Chandra
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Embryotoxic Effect of L-Asparaginase

Nature, 1968
L-Asparaginase catalyses the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Interest in this enzyme has been stimulated by the discovery that it inhibits the growth of several experimental tumours1–3. L-Asparaginase is being used clinically to treat various leukaemias, lymphomas arid melanomas4, and it was recently shown to inhibit the ...
R H, Adamson, S, Fabro
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Antiviral Activity of L-Asparaginase

Nature New Biology, 1971
L-ASPARAGINASE has anti-leukaemic and immunosuppressive activities1 and following the observation that L-asparaginase inhibits plaque formation in L mouse fibroblast cultures by herpes simplex virus2, we report studies of the activity of the enzyme on the multiplication of several human and animal viruses in cell cultures. A preparation of L-asparagine-
R, Maral, G H, Werner
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Polyethylene glycol-L-asparaginase and L-asparaginase studies in rabbits.

Drug Metabolism and Disposition, 1988
Injections of polyethylene glycol (PEG)-L-asparaginase or L-asparaginase were given to two rabbits each at doses of 40 units/kg. Ten min following injection of either enzyme preparation, the plasma enzyme concentration was approximately 1 unit/ml. This level decreased steadily in the rabbits given L-asparaginase, with a t1/2 of approximately 20 hr.
D H, Ho, C Y, Wang, J R, Lin, N, Brown, R A, Newman, I H, Krakoff   +5 more
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Clinical Experience with L-Asparaginase

1970
Three sources of L-asparaginase, two derived from E. coli (supplied by E. R. Squibb and Farbenfabriken Bayer AG), and one obtained from Erwinia carotovora (supplied by the Microbiological Research Establishment, Porton) have been made available to us and have been used in the treatment of acute myeloid leukemia, acute lymphoblastic leukemia ...
G, Hamilton-Fairley, J S, Malpas, D A, Galton   +2 more
openaire   +4 more sources