Results 191 to 200 of about 15,313,595 (281)

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Deconstruction of Aspartic Protease Inhibitors Enables Fragment-Based Discovery of Plasmepsin V Inhibitors. [PDF]

ChemMedChem
Skvorcova M, Ruduša L, Zelencova-Gopejenko D, Jirgensons A, Bobrovs R.   +4 more
europepmc   +1 more source

Theoretical Analysis of Androstenone Adsorption on Chimpanzee and Gorilla Olfactory Receptors (G‐Protein): Statistical Physics Modeling, Molecular Docking Simulation, and Thermodynamic Investigation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT An advanced theory based on statistical physics was applied to microscopically investigate androstenone adsorption and its relationship with olfactory perception in chimpanzees and gorillas. For this purpose, dose–response curves of androstenone on olfactory receptors of chimpanzee OR7D4 and gorilla OR7D4 were analyzed by statistical physics ...
Ismahene Ben Khemis, Olfa Noureddine, Fatma Aouaini, Ghadeer Mohsen Albadrani, Ana Carolina Ferreira Piazzi Fuhr, Nizar Lefi, Salah Knani, GuilhermeLuiz Dotto, Abdelmottaleb Ben Lamine   +8 more
wiley   +1 more source

Spatial Distribution Characterization of Hormonal Metabolites in Morphologically Diverse Jujube Fruits via MALDI-MS Imaging. [PDF]

Foods
Lu D, Zhang Y, Wu Y, Pan Q, Lu F.
europepmc   +1 more source

Distinct Conformational Switches Control WPD‐Loop Dynamics Across Protein Tyrosine Phosphatase Subfamilies

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein Tyrosine Phosphatases (PTPs) regulate cellular signaling by balancing phosphotyrosine levels through a conserved WPD‐loop that switches between open (inactive) and closed (active) conformations. While this conformational change is crucial for catalysis, the structural factors governing this motion remain poorly understood.
Colin L. Welsh, Lalima K. Madan
wiley   +1 more source

Metabolite profiling of saliva for the discrimination of Behcet's disease, Sjögren's syndrome, and recurrent aphthous stomatitis. [PDF]

PLoS One
Kim S, Zhang M, Ahn JK, Hwang J.
europepmc   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source

Correlation Analysis and Spiking Validation of Flavor Compounds Modulating Bitterness and Astringency in Jasmine Tea. [PDF]

Foods
Liu YJ, Chen JY, Hu MJ, Ye JH, Luo WW.
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Systematic review of amino acid profiles among COVID-19 patients caused by SARS-CoV-2. [PDF]

J Diabetes Metab Disord
Soltani S, Choobineh H, Nabatchian F, Kord M, Nikmanesh B, Razi F, Firouzian H, Majidi Z.   +7 more
europepmc   +1 more source