Results 211 to 220 of about 179,087 (303)

Peptide-Carbon Nanotube Hybrids under Confinement: Structure and Stability from Atomistic Simulations. [PDF]

ACS Omega
Mendanha K, Colherinhas G.
europepmc   +1 more source

ROWVA: A Structure‐Based Metric for Predicting the Pathogenicity of Protein Variants Using Alphafold2

Cancer Science, EarlyView.
This study investigates whether several AF2‐derived scores can predict functional scores and pathogenicity labels, and suggests that the root mean square deviation between the wild‐type and variant structures predicted by AlphaFold2 (ROWVA) may be the most effective predictor. This approach may also be applicable to other multimeric proteins.
Taiki Furutani, Yuka Okusha, Hiroki Nagami, Hiroko Hanafusa, Shuta Tomida, Ryusuke Sawada, Yasuyuki Hosono, Masahiro Nakatochi   +7 more
wiley   +1 more source

Metabolomic profiling of varicocele-induced male infertility: insights from spermatic vein blood analysis. [PDF]

Front Endocrinol (Lausanne)
Wei X, Yu Z, Wang S, Zhong D, Wang Y, Zhang X, Shao W, Yan X, Qin C, Song N.   +9 more
europepmc   +1 more source

Two Metschnikowia nectar yeast species have similar volatile profiles but elicit differential foraging in bee pollinators

Ecological Entomology, EarlyView.
Yeasts that specialize in flower nectar play an important role in pollination ecology. Metschnikowia reukaufii and Metschnikowia koreensis were the most prevalent nectar yeasts found in our field sites. Bee pollinators exhibited different behavioural responses to nectar yeasts in field experiments. Bees visited more flowers with M.
M. Elizabeth Moore, Lindsey Wilson, Nathan Brandt, Ayako Wada‐Katsumata, Ahmed M. Saveer, Coby Schal, Robert R. Dunn, Rebecca E. Irwin, Caiti Smukowski Heil   +8 more
wiley   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Differential Metabolites Before and After Allergen Specific Immunotherapy in Children with Allergic Asthma. [PDF]

J Asthma Allergy
Yue Y, Sang M, Zhang S, Hu S, Zhang Y, Zhang S.   +5 more
europepmc   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Development of a Polymeric Antiscalant Having Chelating Motifs of Aspartic and Maleic Acid for Inhibiting Scale Formation on Reverse Osmosis Membranes. [PDF]

ACS Omega
Ali SA, Yaagoob IY, Al-Taq AA, Al-Muallem HA, Rahman F.   +4 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Nearest neighbour interactions between amino acid residues in short peptides and coil libraries. [PDF]

RSC Adv
Schweitzer-Stenner R.
europepmc   +1 more source