Results 41 to 50 of about 392,541 (251)

Aspartic acid incorporated monolithic columns for affinity glycoprotein purification [PDF]

, 2014
WOS: 000331596100009PubMed ID: 24161508Novel aspartic acid incorporated monolithic columns were prepared to efficiently affinity purify immunoglobulin G (IgG) from human plasma. The monolithic columns were synthesised in a stainless steel HPLC column (20
Bereli, Nilay, Bayram, Engin, Say, Ridvan, Armutcu, Canan, Say, Rıdvan, Denizli, Adil, Uzun, Lokman   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Changes of Metabolites and Related Flavors in Mandarin Fish (Siniperca chuatsi) during 24 h of Refrigeration [PDF]

Shipin Kexue
The study aimed to investigate the changes of metabolites and related flavors in the muscle of fresh mandarin fish (Siniperca chuatsi) during 24 h of postmortem refrigeration at 4 ℃ by ultra performance liquid chromatography coupled with high resolution ...
ZHOU Beibei, WU Minglin, JIANG Yangyang, SUN Yongxu, LI Haiyang, CUI Kai
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

L-Aspartic and L-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation [PDF]

, 2016
A series of novel aryloxyphosphoramidate nucleoside prodrugs based on l-aspartic acid and l-glutamic acid as amino acid motif has been synthesized and evaluated for antitumoral activity.
Gao, Ling-Jie, Herdewijn, Piet, Daelemans, Dirk, De Jonghe, Steven   +3 more
core   +1 more source

Vibrational Spectroscopy and Phonon-Related Properties of the l‑Aspartic Acid Anhydrous Monoclinic Crystal [PDF]

, 2015
The infrared absorption and Raman scattering spectra of the monoclinic P21 l-aspartic acid anhydrous crystal were recorded and interpreted with the help of density functional theory (DFT) calculations.
E. M. Bezerra (1464268), E. L. Albuquerque (1464253), V. N. Freire (1464250), A. M. Silva (1464262), S. N. Costa (1464265), R. P. Santos (1464274), U. L. Fulco (1464271), E. W. S. Caetano (1464256), F. A. M. Sales (1464259)   +8 more
core   +5 more sources

Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction

Biomolecules
Myocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment elevation MI (NSTEMI), is still a leading cause of death worldwide.
Jie Zhou, Hai-Tao Hou, Yu Song, Xiao-Lin Zhou, Huan-Xin Chen, Li-Li Zhang, Hong-Mei Xue, Qin Yang, Guo-Wei He   +8 more
doaj   +1 more source

Studies on the Electrochemical Behaviors of Epinephrine at a Poly(l-aspartic acid) Modified Glassy Carbon Electrode and Its Analytical Application

International Journal of Electrochemical Science, 2011
The electrochemical behaviors of Epinephrine (EP) on a poly(l-aspartic acid) membrane are studied by cyclic voltammetry and electrochemical impedance spectroscopy (EIS).
YU Zhang-yu, LI Xiao-chun, WANG Xue-liang, Li Jinjin, CAO Ke-wei   +4 more
doaj   +1 more source

Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice

Nutrition & Metabolism, 2022
Objects Caloric restriction (CR) is known to extend lifespan and exert a protective effect on organs, and is thus a low-cost and easily implemented approach to the health maintenance. However, there have been no studies that have systematically evaluated
Dadi Xie, Jinxi Huang, Qiang Zhang, Shiyuan Zhao, Hongjia Xue, Qing-Qing Yu, Zhuohao Sun, Jing Li, Xiumei Yang, Minglei Shao, Deshui Pang, Pei Jiang   +11 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source