Results 41 to 50 of about 179,087 (303)

Studies on the Electrochemical Behaviors of Epinephrine at a Poly(l-aspartic acid) Modified Glassy Carbon Electrode and Its Analytical Application

open access: yesInternational Journal of Electrochemical Science, 2011
The electrochemical behaviors of Epinephrine (EP) on a poly(l-aspartic acid) membrane are studied by cyclic voltammetry and electrochemical impedance spectroscopy (EIS).
YU Zhang-yu   +4 more
doaj   +1 more source

Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice

open access: yesNutrition & Metabolism, 2022
Objects Caloric restriction (CR) is known to extend lifespan and exert a protective effect on organs, and is thus a low-cost and easily implemented approach to the health maintenance. However, there have been no studies that have systematically evaluated
Dadi Xie   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction

open access: yesBiomolecules
Myocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment elevation MI (NSTEMI), is still a leading cause of death worldwide.
Jie Zhou   +8 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

The Key Metabolites in Rice Quality Formation of Conventional japonica Varieties

open access: yesCurrent Issues in Molecular Biology, 2023
To understand differences in the quality of different conventional japonica rice varieties and variations in metabolites related to rice quality, the quality of three conventional japonica varieties was determined, and the metabolites of the milled rice ...
Qiangqiang Xiong   +6 more
doaj   +1 more source

Biosynthesis of N-Acetyl-l-aspartic Acid

open access: yesJournal of Biological Chemistry, 1959
(Received for publication, May 11, 1959) The occurrence of N-acetyl+aspartic acid in mammalian and avian brain at concentrations from 80 to 120 mg per 100 g fresh weight of tissue was demonstrated recently by Tallan et al. (1). The pattern of distribution of acetylaspartic acid in bovine brain was found by Tallan (2) to parallel that of many enzymes ...
openaire   +2 more sources

Біо/ неорганІчнІ наногібрИдИ L-аспарагінової кислоти: отримання, властивості, застосуваннЯ [PDF]

open access: yes, 2013
Синтез дублетноматричних структур GaSe<LАК> та InSe<LАК> дозволив отримати значне зростання фоточутливості та появу фотоіндуктивного відгуку.
Григорчак, Іван Іванович   +4 more
core  

Marinomonas brasilensis sp. nov., isolated from the coral Mussismilia hispida, and reclassification of Marinomonas basaltis as a later heterotypic synonym of Marinomonas communis [PDF]

open access: yes, 2011
A Gram-negative, aerobic bacterium, designated strain R-40503(T), was isolated from mucus of the reef-builder coral Mussismilia hispida, located in the Sao Sebastiao Channel, Sao Paulo, Brazil.
Alves   +14 more
core   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

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