Results 71 to 80 of about 1,567,546 (339)

Effect of L-Aspartic Acid and L-Glutamic Acid on Production of L-Proline [PDF]

Applied Microbiology, 1972
To elucidate the effect of aspartic acid on growth of Kurthia catenaforma during the proline fermentation, this organism was compared with other bacteria with respect to the rate of consumption of aspartic acid, and to the activities of enzymes concerned in the metabolism of aspartic acid.
J, Kato, M, Kisumi, I, Chibata
openaire   +2 more sources

N-acetyl-L-aspartic acid-N

, 2002
In this study, we generated and analyzed the side-chain conformational potential energy hypersurfaces for each of the nine possible backbone conformers for N-acetyl-L-aspartic acid-N' methylamide.
A. Perczel, J. C.P. Koo, G. A. Chass, J. Gy. Papp, I. G. Csizmadia, A. Varro, Ö. Farkas, L. L. Torday   +7 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Product Selectivity of Esterification of L-Aspartic Acid and L-Glutamic Acid Using Chlorotrimethylsilane

Natural Product Communications, 2017
TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols.
Tomohiro Takaishi, Minoru Izumi, Ryo Ota, Chieri Inoue, Hiromasa Kiyota, Koichi Fukase   +5 more
doaj   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn’s disease

EMBO Molecular Medicine
Intestinal fibrosis is the primary cause of disability in patients with Crohn’s disease (CD), yet effective therapeutic strategies are currently lacking.
Xuehua Li, Shixian Hu, Xiaodi Shen, Ruonan Zhang, Caiguang Liu, Lin Xiao, Jinjiang Lin, Li Huang, Weitao He, Xinyue Wang, Lili Huang, Qingzhu Zheng, Luyao Wu, Canhui Sun, Zhenpeng Peng, Minhu Chen, Ziping Li, Rui Feng, Yijun Zhu, Yangdi Wang, Zhoulei Li, Ren Mao, Shi-Ting Feng   +22 more
doaj   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Enantioselective Synthesis of Homosphingosine Derivatives from l-Aspartic Acid [PDF]

Synthesis, 2009
The sterically demanding 9-phenylfluorenyl N-protection of a number of amino acids allows the formation of amino acid derived β-ketophosphonate reagents and their Horner-Wadsworth-Emmons olefination. In an attempt to develop a synthesis of D-erythro-homosphingosine in enantiopure form, we have shown that the reactivity of the intermediates is ...
Sauerland, Sami J.K., Castillo-Melendez, Joel A., Nattinen, Kalle, Rissanen, Kari, Koskinen, Ari M.P.   +4 more
openaire   +2 more sources

Regulation of glycolipid and amino acid metabolism in juvenile triploid crucian carp (Carassius auratus) by oral administration of aspartic acid

Aquaculture Reports
Aspartic acid, a nonessential amino acid, plays crucial roles in protein synthesis, tricarboxylic acid cycle, and glycolipid metabolism in mammals. However, corresponding studies of the role of aspartic acid in fish remain limited.
Yu Wang, Bo Dong, Liyun Wu, Dong Han, Xiaoming Zhu, Haokun Liu, Yunxia Yang, Shouqi Xie, Zhen Liu, Junyan Jin   +9 more
doaj   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source