Results 31 to 40 of about 56,359 (264)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Effects of Oral L-Carnitine on Liver Functions after Transarterial Chemoembolization in Intermediate-Stage HCC Patients

Mediators of Inflammation, 2015
Transarterial chemoembolization (TACE) is usually followed by hepatic dysfunction. We evaluated the effects of L-carnitine on post-TACE impaired liver functions. Methods.
Abeer Hassan, Yasuhiro Tsuda, Akira Asai, Keisuke Yokohama, Ken Nakamura, Tetsuya Sujishi, Hideko Ohama, Yusuke Tsuchimoto, Shinya Fukunishi, Usama M. Abdelaal, Usama A. Arafa, Ali T. Hassan, Ali M. Kassem, Kazuhide Higuchi   +13 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy

Frontiers in Pharmacology, 2023
Lenvatinib is an oral tyrosine kinase inhibitor that acts on multiple receptors involved in angiogenesis. Lenvatinib is a standard agent for the treatment of several types of advanced cancers; however, it frequently causes muscle-related adverse ...
Zheng Jing, Tomohiro Iba, Tomohiro Iba, Hisamichi Naito, Pingping Xu, Jun-ichi Morishige, Naoto Nagata, Hironao Okubo, Hitoshi Ando   +8 more
doaj   +1 more source

Comparison of pharmacokinetics of L-carnitine, Acetyl-L-carnitine and Propionyl-Lcarnitine after single oral administration of L-carnitine in healthy volunteers

Clinical and Investigative Medicine, 2009
Purpose To investigate the pharmacokinetics of L-carnitine (LC) and its analogues, acetyl-L-carnitine (ALC) and propionyl -L-carnitine (PLC) in healthy volunteers after single L-carnitine administration. Methods Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects.
Yu, Cao, Yun-xiao, Wang, Cheng-juan, Liu, Le-xin, Wang, Zhi-wu, Han, Chun-bo, Wang   +5 more
openaire   +3 more sources

Effect of L-carnitine on Bone Strength: An Experimental Study

Türk Osteoporoz Dergisi
Objective: Decreased bone density and strength increase the risk of fracture and thus the rates of morbidity and mortality. L-carnitine (LC) is a supplement commonly used by individuals who participate in sports, especially to increase muscle mass.
Zehra Seznur Kasar, Figen Sevil Kilimci, Buket Demirci   +2 more
doaj   +1 more source

L-Carnitine Supports the In Vitro Growth of Buffalo Oocytes

Animals, 2022
This study aimed to determine the effect of L-carnitine on the growth and subsequent nuclear maturation of buffalo small growing oocytes (92–108 µm in diameter) in vitro.
Avijit Kumar Modak, Md Hasanur Alam, Md Nuronnabi Islam, Nipa Paul, Ireen Akter, Md Abul Hashem, AKM Ahsan Kabir, Mohammad Moniruzzaman   +7 more
doaj   +1 more source

Systematic Evaluation of Key L-Carnitine Homeostasis Mechanisms during Postnatal Development in Rat

Nutrition & Metabolism, 2012
Background The conditionally essential nutrient, L-carnitine, plays a critical role in a number of physiological processes vital to normal neonatal growth and development.
Ling Binbing, Aziz Caroline, Alcorn Jane
doaj   +1 more source

Urinary excretion of L-carnitine, acetyl-L-carnitine, propionyl-L-carnitine and their antioxidant activities after single dose administration of L-carnitine in healthy subjects [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2013
The urine excretion of L-carnitine (LC), acetyl-L-carnitine (ALC) and propionyl-Lcarnitine (PLC) and their relations with the antioxidant activities are presently unknown. Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Urine concentrations of LC, ALC and PLC were detected by HPLC. Superoxide dismutase (SOD),
Cao, Yu, Hao, Chuan-ji, Wang, Chen-jing, Li, Peng-li, Wang, Le-xin, Guan, Hua-shi, Li, Huan-ting   +6 more
openaire   +4 more sources