Results 101 to 110 of about 31,622 (258)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Oral L-Citrulline Supplementation Improves Fatty Liver and Dyslipidemia in Adolescents with Abdominal Obesity: A Parallel, Double-Blind, Randomized Clinical Trial

Gastroenterology Insights
Obesity in adolescents is associated with non-communicable risk factors and diseases like metabolic-associated fatty liver disease (MAFLD), which is the liver manifestation of metabolic syndrome.
Verónica Ivette Tovar-Villegas, Yejin Kang, Lorena del Rocío Ibarra-Reynoso, Montserrat Olvera-Juárez, Armando Gomez-Ojeda, Víctor Manuel Bosquez-Mendoza, Miriam Lizette Maldonado-Ríos, Ma. Eugenia Garay-Sevilla, Arturo Figueroa   +8 more
doaj   +1 more source

Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis

Journal of Nutrition and Metabolism, 2016
Glutamine supplementation in specific groups of critically ill patients results in favourable clinical outcome. Enhancement of citrulline and arginine synthesis by glutamine could serve as a potential mechanism.
Mechteld A. R. Vermeulen, Saskia J. H. Brinkmann, Nikki Buijs, Albertus Beishuizen, Pierre M. Bet, Alexander P. J. Houdijk, Johannes B. van Goudoever, Paul A. M. van Leeuwen   +7 more
doaj   +1 more source

Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from 100 volunteers with RA and PD (RAPD), 22 with RA (RAnoPD), 18 with PD (PDnoRA) and 19 healthy controls (noRAnoPD) was analysed using 16S‐amplicon ...
Isabel Lopez‐Oliva, Iain L. Chapple, Akshay Paropkari, Shweta Saraswat, Praveen Sharma, Stefan Serban, Paola de Pablo, Karim Raza, Andrew Filer, Thomas Dietrich, Melissa Grant, Purnima S. Kumar   +11 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Identification of nitric oxide synthase in human and bovine oviduct [PDF]

, 2017
Nitric oxide synthase (NOS) is responsible for the biological production of nitric oxide (NO) in several organs. NOS activity has also been localized in the reproductive tract, although direct evidence for its presence in the human or bovine oviduct is ...
Dubey, R.K., Fink, D., Imthurn, B., Keller, P.J., Lauper, U., Macas, E., Rosselli, M., Rosselli, M.A.   +7 more
core  

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis [PDF]

, 2016
Liver fibrosis, a consequence of chronic liver injury and a way station to cirrhosis and hepatocellular carcinoma, lacks effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) induce profibrotic gene expression and promote ...
Cao, Z., Cinar, R., Erdélyi, Katalin, Iyer, M. R., Jourdan, T., Liu, Z., Pacher, Pál, Szanda, Gergő   +7 more
core   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Storage stability of L-citrulline in cucumber (Cucumis sativus) and watermelon (Citrullus lanatus) juices / Estabilidade em armazenamento de L-citrulina em sucos de pepino (Cucumis sativus) e melancia (Citrullus lanatus) [PDF]

, 2021
Since foods rich in L-citrulline are important for vascular health, it is important to determine the amount of this compounds in foods present in the human diet.
Alvares, Thiago da Silveira, de Oliveira, Gustavo Vieira, de Souza, Mônica Volino Gonçalves, Junior, Carlos Adam Conte, Pinheiro, Vivian dos Santos   +4 more
core   +1 more source

Physiological, Performance and Perceptual Effects of Acute Intake of an L-Arginine and L-Citrulline Beverage Prior to a Repeated Bout of Intensive Running Among University Soccer Players

Nutraceuticals
The purpose of this study was to determine whether a combined L-arginine and L-citrulline beverage can enhance total nitric oxide (NOx), as well as physiological (cardiopulmonary metrics) and perceptual (rate of perceived exertion) responses to a ...
Siphamandla Nyawose, Rowena Naidoo, Nenad Naumovski, Andrew J. McKune   +3 more
doaj   +1 more source