Results 71 to 80 of about 694,012 (248)

Synthesis, Characterisation and Antimicrobial Evaluation of a New Bis(semicarbazone) Ligand and Its Coordination Complexes [PDF]

مجلة جامعة الانبار للعلوم الصرفة
This study aimed to synthesise a new multidentate bis(semicarbazone) ligand, (2Z,2'E)-2,2'-(((propane-1,3-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))-bis(hydrazine-1-carboxamide) (H₂L), and to investigate its paramagnetic coordination compounds
Mohamad Hameed, Mohamad Al-Jeboori
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effects of Different Extraction Methods on the Composition and Properties of Jinggang Pomelo Peel Essential Oil

Shipin gongye ke-ji
Taking Jinggang pomelo peel essential oil (JPPEO) as the research object, two methods of steam distillation and low-temperature continuous phase transition were used for extraction. Orthogonal test was used to study the effects of extraction temperature,
Xin LI, Jianxin HUA, Jiehong LUO, Guoqing WANG, Gan CHEN, Aimei ZHOU   +5 more
doaj   +1 more source

Dimorphism of Trichosporon cutaneum and impact on its lipid production

Biotechnology for Biofuels, 2019
Background Compared to the oleaginous yeast Yarrowia lipolytica, Trichosporon cutaneum can metabolize pentose sugars more efficiently, and in the meantime is more tolerant to inhibitors, which is suitable for lipid production from lignocellulosic biomass.
Ya Wang, Riming Yan, Lijuan Tang, Libin Zhu, Du Zhu, Fengwu Bai   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Determination of confinement regime boundaries via separatrix parameters on Alcator C-Mod based on a model for interchange-drift-Alfvén turbulence

Nuclear Fusion
The separatrix operational space (SepOS) model (Eich and Manz 2021 Nucl. Fusion 61 086017) is shown to predict the L–H transition, the L-mode density limit, and the ideal magnetohydrodynamic ballooning limit in terms of separatrix parameters for a wide ...
M.A. Miller, J.W. Hughes, T. Eich, G.R. Tynan, P. Manz, T. Body, D. Silvagni, O. Grover, A.E. Hubbard, A. Cavallaro, M. Wigram, A.Q. Kuang, S. Mordijck, B. LaBombard, J. Dunsmore, D. Whyte   +15 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source