Results 231 to 240 of about 312,266 (316)

An atypical presentation in a child with propionic acidemia? Better think twice! [PDF]

open access: yesJIMD Rep
Burkhardt T   +9 more
europepmc   +1 more source

Engineering an Overflow‐Responsive Regulation System for Balancing Cellular Redox and Optimizing Microbial Production

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose as carbon source. This phenomenon, known as overflow metabolism, has negative impacts on cell growth and protein expression, also causes carbon loss during biosynthesis in most microbial production scenarios. In this study, we regarded the “
Jianli Zhang   +8 more
wiley   +1 more source

Establishing a 3D Vascularized Tri‐Culture Model of the Human Airways via a Digital Light Processing Bioprinter

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The rise in chronic lung diseases globally and the corresponding lag in drug discovery in this field highlights the need for In Vitro models closely mimicking In Vivo lung tissue. Efforts to date have largely focused on In Vitro coculture models, often neglecting the pulmonary vasculature's role in lung physiology and lacking perfusability. To
Sakshi Phogat   +3 more
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

Hyperpolarized <sup>13</sup>C-MRS can Quantify Lactate Production and Oxidative PDH Flux in Murine Skeletal Muscle During Exercise. [PDF]

open access: yesNMR Biomed
Curtis MK   +10 more
europepmc   +1 more source

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