Results 51 to 60 of about 229,589 (299)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Evaluation of Lactate Dehydrogenase and Alkaline Phosphatase as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram [PDF]

, 2023
Ke Su,1,* Weihong Huang,2,* Xueting Li,3,* Ke Xu,4,* Tao Gu,1 Yanlin Liu,1 Juan Song,2 Keyi Qian,5 Yaoyang Xu,2 Hao Zeng,1 Yipei Yang,6 Lu Guo,7 Yunwei Han1 1Department of Oncology, The Affiliated Hospital of Southwest Medical University,
Gu T, Xu K, Su K, Han Y, Song J, Li X, Liu Y, Guo L, Yang Y, Huang W, Zeng H, Qian K, Xu Y   +12 more
core  

EFFECT OF FOUR BIOACTIVE COMPOUNDS SEPARATELY AND IN COMBINATION WITH Metarhizium anisopliae ON THE ACTIVITY OF SOME HAEMOLYMPH ENZYMES OF Schistocerca gregaria (FORSKAL). [PDF]

Journal of Plant Protection and Pathology, 2015
The effect of Metarhizium anisopliae var.acridum and four bioactive compounds (Neem,L- Glutamic acid,Schinusmolle and abamectin) in sole treatments and in combination with M.
M. El - Dydamony, G. Abdelatef, T. Abd- Elfattah, A. Farrag   +3 more
doaj   +1 more source

Expression of Microbial Enzymes in Mammalian Astrocytes to Modulate Lactate Release

Brain Sciences, 2021
Astrocytes support and modulate neuronal activity through the release of L-lactate. The suggested roles of astrocytic lactate in the brain encompass an expanding range of vital functions, including central control of respiration and cardiovascular ...
Barbara Vaccari Cardoso, Iliana Barrera, Valentina Mosienko, Alexander V. Gourine, Sergey Kasparov, Anja G. Teschemacher   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Prognostic significance of serum lactate dehydrogenase in patients with breast cancer: a meta-analysis [PDF]

, 2019
Dongbo Liu,1 Dingkun Wang,2 Cheng Wu,1 Linli Zhang,1 Qi Mei,1 Guangyuan Hu,1 Guoxian Long,1 Wei Sun11Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s ...
Long G, Hu G, Wang D, Wu C, Zhang L, Sun W, Liu D, Mei Q   +7 more
core  

The primary pathway for lactate oxidation in Desulfovibrio vulgaris

Frontiers in Microbiology, 2015
The ability to respire sulfate linked to lactate oxidation is a key metabolic signature of the Desulfovibrio genus. Lactate oxidation by these incomplete oxidizers generates reductants through lactate dehydrogenase (LDH) and pyruvate-ferredoxin ...
Laetitia ePieulle, Nicolas eVita, Odile eValette, Gaël eBrasseur, Sabrina eLignon, Yann eDenis, Mireille eAnsaldi, Alain eDolla   +7 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source