Results 31 to 40 of about 229,589 (299)

Human d‐lactate dehydrogenase deficiency by LDHD mutation in a patient with neurological manifestations and mitochondrial complex IV deficiency

JIMD Reports, 2021
Background d‐lactate, one of the isomers of lactate, exists in a low concentration in healthy individuals and it can be oxidized to pyruvate catalyzed by d‐lactate dehydrogenase.
Anna Ka‐Yee Kwong, Sheila Suet‐Na Wong, Richard J. T. Rodenburg, Jan Smeitink, Godfrey Chi Fung Chan, Cheuk‐Wing Fung   +5 more
doaj   +1 more source

Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Microbiome, 2022
Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the ...
Savannah J. Taylor, Maria G. Winter, Caroline C. Gillis, Laice Alves da Silva, Amanda L. Dobbins, Matthew K. Muramatsu, Angel G. Jimenez, Rachael B. Chanin, Luisella Spiga, Ernesto M. Llano, Vivian K. Rojas, Jiwoong Kim, Renato L. Santos, Wenhan Zhu, Sebastian E. Winter   +14 more
doaj   +1 more source

Absence of Evidence for Metabolite-Modulated Association between α-Glycerol-3-phosphate Dehydrogenase and l-Lactate Dehydrogenase^† [PDF]

, 2016
Evidence for the NADH-modulated formation of a complex between α-glycerol-3-phosphate dehydrogenase and l-lactate dehydrogenase was reported [Yong, H., Thomas, G. A., and Peticolas, W. L. (1993) Biochemistry 32, 11124−11131].
Franklin A. Hays (1587643), H. Olin Spivey (2947635), Marina V. Kovina (2947638), Eric A. Lehoux (2947641), Sharon M. Baker (2947632)   +4 more
core   +1 more source

Relative catalytic efficiencies and transcript levels of three d‐ and two l‐lactate dehydrogenases for optically pure d‐lactate production in Sporolactobacillus inulinus

MicrobiologyOpen, 2019
As the optical purity of the lactate monomer is pivotal for polymerization, the production of optically pure d‐lactate is of significant importance. Sporolactobacillus inulinus YBS1‐5 is a superior optically pure d‐lactate‐producing bacterium.
Bin Wu, Qi Yu, Shan Zheng, Marcelo Monteiro Pedroso, Luke W. Guddat, Bingfang He, Gerhard Schenk   +6 more
doaj   +1 more source

Non-sterilized fermentation of high optically pure d-lactic acid by a genetically modified thermophilic Bacillus coagulans strain

Microbial Cell Factories, 2017
Background Optically pure d-lactic acid (≥ 99%) is an important precursor of polylactic acid. However, there are relatively few studies on d-lactic acid fermentation compared with the extensive investigation of l-lactic acid production.
Caili Zhang, Cheng Zhou, Nilnate Assavasirijinda, Bo Yu, Limin Wang, Yanhe Ma   +5 more
doaj   +1 more source

The Core of Allosteric Motion in Thermus caldophilus l-Lactate Dehydrogenase [PDF]

Journal of Biological Chemistry, 2014
For Thermus caldophilus L-lactate dehydrogenase (TcLDH), fructose 1,6-bisphosphate (FBP) reduced the pyruvate S(0.5) value 10(3)-fold and increased the V(max) value 4-fold at 30 °C and pH 7.0, indicating that TcLDH has a much more T state-sided allosteric equilibrium than Thermus thermophilus L-lactate dehydrogenase, which has only two amino acid ...
Yoko Ikehara, Kazuhito Arai, Nayuta Furukawa, Tadashi Ohno, Tatsuya Miyake, Shinya Fushinobu, Masahiro Nakajima, Akimasa Miyanaga, Hayao Taguchi   +8 more
openaire   +2 more sources

Null and electrophoretic mobility mutants in the structural gene for L-lactate dehydrogenase of Saccharomyces cerevisiae [PDF]

, 1986
A mutant lacking L-lactate dehydrogenase (EC 1.1.2.3) of Saccharomyces cerevisiae was isolated by its inability to grow on minimal medium with L-lactate as a carbon source.
Sbragia, Ralph, Christopher Wills, Wills, Christopher, Ralph Sbragia, Rush, Karen, Karen Rush   +5 more
core   +1 more source

Identification of the genes that contribute to lactate utilization in Helicobacter pylori. [PDF]

PLoS ONE, 2014
Helicobacter pylori are Gram-negative, spiral-shaped microaerophilic bacteria etiologically related to gastric cancer. Lactate utilization has been implicated although no corresponding genes have been identified in the H. pylori genome.
Shun Iwatani, Hiroyuki Nagashima, Rita Reddy, Seiji Shiota, David Y Graham, Yoshio Yamaoka   +5 more
doaj   +1 more source

Significance of Elevated Synovial Fluid Lactic Acid and Lactate Dehydrogenase Levels in Differentiating Between Septic Arthritis, Inflammatory Arthritis and Non-Inflammatory Arthritis

Pakistan Armed Forces Medical Journal, 2022
Objective: To determine the lactic acid and lactate dehydrogenase levels in synovial fluid and differentiate between inflammatory and non-inflammatory arthritis. Study Design: Cross-sectional study.
Uzma Erum, Tahira Perveen Umer, Shafiq-ur Rehman Arain, Muhammad Rashid Ahmed, Lubna Nazir   +4 more
doaj   +1 more source

Evidence that L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans [PDF]

Infection and Immunity, 1994
In order to construct an effector strain for the replacement therapy of dental caries, we wished to combine the properties of low-level acid production and high-level colonization potential in a strain of Streptococcus mutans. To this end, we made a deletion in the lactate dehydrogenase (LDH) gene cloned from the bacteriocin-producing S.
J D, Hillman, A, Chen, M, Duncan, S W, Lee   +3 more
openaire   +2 more sources