Results 11 to 20 of about 183,054 (259)

Expression of Lactate Dehydrogenase in Aspergillus niger for L-Lactic Acid Production. [PDF]

PLoS ONE, 2015
Different engineered organisms have been used to produce L-lactate. Poor yields of lactate at low pH and expensive downstream processing remain as bottlenecks.
Khyati K Dave, Narayan S Punekar
doaj   +1 more source

Bioinformatics Analysis and Gene Cloning of L-Lactate Dehydrogenase from Lactobacillus rhamnosus

Shipin gongye ke-ji, 2023
In this study, L-lactate dehydrogenase (Lr-L-LDH) from Lactobacillus rhamnosus was investigated. The well-known Lr-L-LDH1 was taken as the control, differences between Lr-L-LDH1 and Lr-L-LDH2 annotated from the genome of L. rhamnosus were analyzed.
Liming XU, Guofeng JIANG, Xinling WU, Xiufang LIAO, Xiajie LAO, Hanchun YA, Xiunian LI   +6 more
doaj   +1 more source

L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells in vitro

iScience, 2021
Summary: L-lactate has energetic and signaling properties, and its availability is modulated by activity-dependent stimuli, which also regulate adult hippocampal neurogenesis.
Alexandra Pötzsch, Sara Zocher, Stefanie N. Bernas, Odette Leiter, Annette E. Rünker, Gerd Kempermann   +5 more
doaj   +1 more source

D- and L-lactate dehydrogenases during invertebrate evolution [PDF]

BMC Evolutionary Biology, 2008
The L-lactate and D-lactate dehydrogenases, which are involved in the reduction of pyruvate to L(-)-lactate and D(+)-lactate, belong to evolutionarily unrelated enzyme families. The genes encoding L-LDH have been used as a model for gene duplication due to the multiple paralogs found in eubacteria, archaebacteria, and eukaryotes.
Cristescu, M.E., Innes, D., Stillman, Jonathon H., Crease, T.J.   +3 more
openaire   +3 more sources

Elevated LDH greater than 400 U/L portends poorer overall survival in diffuse large B-cell lymphoma patients treated with CD19 CAR-T cell therapy in a real world multi-ethnic cohort

Experimental Hematology & Oncology, 2021
Anti-CD19 chimeric antigen receptor T-cell therapies have shown striking clinical activity in diffuse large B-cell lymphoma but robust biomarkers predictive of responsiveness are still needed.
Emma Rabinovich, Kith Pradhan, R. Alejandro Sica, Lizamarie Bachier-Rodriguez, Ioannis Mantzaris, Noah Kornblum, Aditi Shastri, Kira Gritsman, Mendel Goldfinger, Amit Verma, Ira Braunschweig   +10 more
doaj   +1 more source

L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans [PDF]

Journal of Bacteriology, 1994
The previously cloned gene for L-(+)-lactate dehydrogenase (LDH) from Streptococcus mutans was mutagenized in vitro. An Escherichia coli transformant which expressed a thermolabile LDH activity was identified. The ldh(Ts) gene was introduced into S.
A, Chen, J D, Hillman, M, Duncan
openaire   +2 more sources

Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues

Redox Biology, 2020
Research over the past seventy years has established that mitochondrial-l-lactate dehydrogenase (m-L-LDH) is vital for mitochondrial bioenergetics. However, in recent report, Fulghum et al.
Adrian Young, Catherine Oldford, Ryan J. Mailloux   +2 more
doaj   +1 more source

Serum lactate dehydrogenase is associated with impaired lung function: NHANES 2011-2012.

PLoS ONE, 2023
BackgroundSerum lactate dehydrogenase levels reflect disease status in a variety of organs, but its role in indicating pulmonary function is not yet clear.
Sheng Hu, Jiayue Ye, Qiang Guo, Sheng Zou, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Silin Wang, Lang Su, Yiping Wei   +9 more
doaj   +1 more source

DIAGNOSTIC UTILITY OF SERUM LACTATE DEHYDROGENASE LEVELS (LDL) IN DIFFERENTIATING MEGALOBLASTIC ANEMIA FROM MYELODYSPLASTIC SYNDROMES IN PAKISTAN

Pakistan Armed Forces Medical Journal, 2021
Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan. Study Design: Comparative cross-sectional study.
Faraz Ali Rana, Helen Mary Robert, Madiha Ilyas, Asad Mahmood, Muhammad Amir, Nabeela Khan   +5 more
doaj  

Human d‐lactate dehydrogenase deficiency by LDHD mutation in a patient with neurological manifestations and mitochondrial complex IV deficiency

JIMD Reports, 2021
Background d‐lactate, one of the isomers of lactate, exists in a low concentration in healthy individuals and it can be oxidized to pyruvate catalyzed by d‐lactate dehydrogenase.
Anna Ka‐Yee Kwong, Sheila Suet‐Na Wong, Richard J. T. Rodenburg, Jan Smeitink, Godfrey Chi Fung Chan, Cheuk‐Wing Fung   +5 more
doaj   +1 more source