Results 51 to 60 of about 33,795 (256)

Rewiring metabolic flux to simultaneously improve malate production and eliminate by‐product succinate accumulation by Myceliophthora thermophila

open access: yesMicrobial Biotechnology
Although a high titre of malic acid is achieved by filamentous fungi, by‐product succinic acid accumulation leads to a low yield of malic acid and is unfavourable for downstream processing.
Shuying Gu   +7 more
doaj   +1 more source

Decomposition of L-Malic Acid by Schizosaccharomyces Pombe

open access: yesNIPPON SHOKUHIN KOGYO GAKKAISHI, 1972
Schizosaccharomces pombe (IFO 0358) having intrinsically high ability of decomposing L-malic acid, when cultured in a synthetic growth medium, showed weaker ability to decompose L-malic acid than the ability cultured in apple juice, and it suggests that apple juice contains an unidentified factor or factors to promote the L-malic acid decomposition by ...
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

THE PERMEABILITY OF TWO- AND EIGHT-CELL MOUSE EMBRYOS TO l-MALIC ACID [PDF]

open access: yesReproduction, 1968
Summary. The level of radio-isotope in 2- and 8-cell mouse embryos was measured following a 30-min incubation in isotopically labelled malate. Although there was very little accumulation of substrate carbon and no output of radio-active carbon dioxide by 2-cell embryos, 8-cell embryos accumulated substrate carbon during the incubation
R G, Wales, J D, Biggers
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Miniaturized Flow-System Integrating Enzymatic Electrochemical Biosensors for Monitoring the Malolactic Fermentation of Red Wines

open access: yesProceedings, 2017
During the malolactic fermentation (MLF) of red wines, L-malic acid is mainly converted to L-lactic acid. [...]
Pablo Giménez-Gómez   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

CHEMICAL COMPOSITION OF SOME AUTOCHTHONOUS FRUIT SPECIES FROM MACEDONIA

open access: yesJournal of Agriculture and Plant Sciences
The scope of this paper is determination of the content of soluble dry matters, total sugar, total acids, invert sugar and citric, malic, tartaric and lactic acid in some autochthonous fruit species: pomegranate (Zumnarija, Bejnarija, Valandovska kisela,
Ana Selamovska   +3 more
doaj   +1 more source

Effect of Biofilm Formation by Lactobacillus plantarum on the Malolactic Fermentation in Model Wine

open access: yesFoods, 2020
Biofilm life-style of Lactobacillus plantarum (L. plantarum) strains was evaluated in vitro as a new and suitable biotechnological strategy to assure L-malic acid conversion in wine stress conditions. Sixty-eight L.
Gianfranco Pannella   +9 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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