Results 71 to 80 of about 15,248,221 (249)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Convergent synthesis of degradable dendrons based on L-malic acid

, 2015
New degradable polyester dendrons based on the cellular tricarboxylic acid cycle component L-malic acid were synthesized up to the third generation by convergent synthesis.
Meyhoff, Ulrich, Riber, Ulla, Boas, Ulrik   +2 more
core   +1 more source

Effect of malic-lactic fermentation by indigenous lactic acid bacteria on the quality of 'Hu Tai No.11' wine [PDF]

Zhongguo niangzao
In order to study the effects of malic-lactic acid fermentation (MLF) of different lactic acids bacteria on the quality of 'Hutai No.11' wine, the changes of L-malic acid content and its effects on the basic physiochemical indexes, color, phenolics ...
ZHANG Jiaxuan, ZHANG Cuiyi, LIU Hui, ZHANG Biying, JIA Weipeng, SHI Kan, LIU Shuwen
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Engineering Yarrowia lipolytica to Produce l-Malic Acid from Glycerol

The declining availability of cheap fossil-based resources has sparked growing interest in the sustainable biosynthesis of organic acids. l-Malic acid, a crucial four-carbon dicarboxylic acid, finds extensive applications in the food, chemical, and ...
Liu, Chang,, Ding, Chen,, Wang, Yuyang,, Zhang, Cui Ying,, Mao, Jiwei,, Wang, Yaping,, Han, Yuqing,, Ye, Qingqing,, Yu, Aiqun,, Huang, Qingeng,, Cao, Liyan,   +10 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Order and Disorder in the Structures of Two Crystal Polymorphs of the Adduct Bis(Quinolinium-2-Carboxylate) DL-Malic Acid [PDF]

, 2010
The structures of two polymorphs of the anhydrous cocrystal adduct of bis(quinolinium-2-carboxylate) DL-malic acid, one triclinic the other monoclinic and disordered, have been determined at 200 K. Crystals of the triclinic polymorph 1 have space group P-
Urs D. Wermuth, Smith, Graham, Wermuth, Urs D., Wermuth, Urs, Graham Smith, Wermuth, Urs D   +5 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Preparation of poly(β-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery

, 2015
Qing Zhou,1,* Tiehong Yang,1,* Youbei Qiao,1 Songyan Guo,1 Lin Zhu,2 Hong Wu11Department of Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi’an, People’s Republic of China; 2Department of Pharmaceutical ...
Qiao Y, Zhou Q, Zhu L, Guo S, Yang T, Wu H   +5 more
core  

Excretion of l-malic acid in the chicken

, 1960
The mechanism of excretion of malic acid has been studied during infusion of sodium salts of l-malic acid, succinic acid and malonic acid in the chicken.
W. D. Lotspeich, P. Vishwakarma
core   +1 more source