Results 71 to 80 of about 69,834 (346)

Effect of long-term starvation on the survival, recovery, and carbon utilization profiles of a bovine Escherichia coli O157:H7 isolate from New Zealand [PDF]

, 2014
The ability to maintain a dual lifestyle of colonizing the ruminant gut and surviving in nonhost environments once shed is key to the success of Escherichia coli O157:H7 as a zoonotic pathogen.
McDonald, Ian R., Morgan, Hugh W., Withers, Helen, Xavier, Ron Neo   +3 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Rewiring metabolic flux to simultaneously improve malate production and eliminate by‐product succinate accumulation by Myceliophthora thermophila

Microbial Biotechnology
Although a high titre of malic acid is achieved by filamentous fungi, by‐product succinic acid accumulation leads to a low yield of malic acid and is unfavourable for downstream processing.
Shuying Gu, Taju Wu, Junqi Zhao, Tao Sun, Zhen Zhao, Lu Zhang, Jingen Li, Chaoguang Tian   +7 more
doaj   +1 more source

Immobilization of Aspergillus oryzae DSM 1863 for l-Malic Acid Production

Fermentation, 2022
Whole-cell immobilization by entrapment in natural polymers can be a tool for morphological control and facilitate biomass retention. In this study, the possibility of immobilizing the filamentous fungus Aspergillus oryzae for l-malic acid production was
Aline Kövilein, Vera Aschmann, Silja Hohmann, Katrin Ochsenreither   +3 more
doaj   +1 more source

Substrate Induced Denitrification over or under Estimates Shifts in Soil N2/N2O Ratios [PDF]

, 2014
Funding: Funding was provided by the Biotechnology and Biological Sciences Research Council, BBSRC UK (http://www.bbsrc.ac.uk). Grant number BB/H013431/1.
Baggs, Elizabeth M, Morley, Nicholas J, Richardson, David J   +2 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Chemotaxis of Bracken Spermatozoids : The Role of Bimalate Ions [PDF]

, 1958
1. Bracken spermatozoids are chemotactically attracted by malic acid salts and in a pH gradient aggregate between pH 3.5 and 5.6. 2. This response to pH occurs only when the sperm suspension contains malate. 3. At higher pH's, the response to an H+
Brokaw, C. J.
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Miniaturized Flow-System Integrating Enzymatic Electrochemical Biosensors for Monitoring the Malolactic Fermentation of Red Wines

Proceedings, 2017
During the malolactic fermentation (MLF) of red wines, L-malic acid is mainly converted to L-lactic acid. [...]
Pablo Giménez-Gómez, Manuel Gutiérrez-Capitán, Fina Capdevila, Anna Puig-Pujol, Cesar Fernández-Sánchez, Cecilia Jimenez-Jorquera   +5 more
doaj   +1 more source

Identification of the Content of Biologically Active Substances in Nut Shots [PDF]

, 2019
One of ways of the food industry development is a search for non-traditional raw material resources with the high content of physiologically healthy nutrients.
Babich, P. (Philipp), Matsuk, Y. (Yuliiа), Novik, A. (Anna), Oliinyk, S. (Svitlana), Shydakova-Kameniuka, E. (Elena), Zaparenko, A. (Anna), Zhukov, Y. (Yevhenii)   +6 more
core   +3 more sources