Results 131 to 140 of about 713,418 (262)

Drying temperature affects the hypolipidemic, antioxidant, and antihypertensive potential of Hibiscus sabdariffa calyx in rats induced with L-NAME. [PDF]

Toxicol Rep, 2023
Efosa JO, Omage K, Azeke MA.
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Hydrolyzed Collagen from Salmon Skin Mitigates L-NAME-Induced Hypertension in Rats by Attenuating Oxidative Stress and Inflammation and Improving Vascular Remodeling. [PDF]

Int J Mol Sci
Mungmuang P, Tocharus J, Panthiya L, Sungnoon R, Nilsuwan K, Benjakul S, Tocharus C.   +6 more
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

UNI-494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L-NAME and angiotensin II. [PDF]

Physiol Rep
Ho FJM, Siow CJR, Aljaibeji H, Ding M, Mitchell RN, Medicherla S, Reddy G, Gupta S, Williams GH, Romero JR.   +9 more
europepmc   +1 more source

Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats. [PDF]

Cardiovasc Ther, 2023
Razzaq MA, Younis W, Malik MNH, Alsahli TG, Alamgeer, Jahan S, Ehsan R, Gasparotto Junior A, Bashir A.   +8 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Renoprotective effect of dulaglutide in L-NAME-induced hypertensive nephropathy in rats: insight into the roles of PPAR-gamma and VEGF. [PDF]

Hypertens Res
Bastawy N, El-Mosallamy AEMK, Rasheed RA, Sadek AS, Khattab RT, Ali E, Zaghloul RA, Ghaly WBA, Boushra AF.   +8 more
europepmc   +1 more source

Antihypertensive effect of the stem bark aqueous extract of Garcinia lucida Vesque (Clusiaceae) in L-NAME-treated rats: Contribution of endothelium-dependent and -independent vasorelaxation. [PDF]

Heliyon, 2023
Nguelefack-Mbuyo EP, Sonfack CS, Fofié CK, Fodem C, Ndjenda Ii MK, Dongmo AB, Nguelefack TB.   +6 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source