Results 221 to 230 of about 714,505 (261)

l -NAME as a Synthetic Antioxidant in Liver Injuries

2018
Oxidative stress is attributable to a mismatch between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to the body’s antioxidant capacity to readily detoxify the reactive intermediates or mend the ensuing damage. RNS, such as nitric oxide (NO), are synthetized by nitric oxide synthases (NOS).
Ayhancı, Adnan, Appak, Sıla, Cengiz, Mustafa   +2 more
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Vasoactive systems in L-NAME hypertension

Journal of Hypertension, 2004
The contribution of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) to blood pressure (BP) maintenance was evaluated in rats with N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension. Furthermore, we studied the extent of nitric oxide (NO) synthesis inhibition and the participation of remaining NO in the ...
Olga, Pechánová, Zdenka, Dobesová, Jakub, Cejka, Jaroslav, Kunes, Josef, Zicha   +4 more
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Carotid Body Remodelling in l-NAME-Induced Hypertension in the Rat

Journal of Comparative Pathology, 2012
The carotid body (CB) is a chemoreceptor organ located at the bifurcation of the common carotid artery. It is made up of the carotid glomus, a structure containing type 1 cells surrounded by type 2 cells. The aim of this study was to evaluate the morphological changes of the CB and carotid glomus in the rat model of l-NAME-induced hypertension.
A S, Felix, V N, Rocha, A L R, Nascimento, J J, de Carvalho   +3 more
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l-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice

Brain Research, 1997
Nitric oxide (NO) formation has been shown in many neuronal tissues subserves a variety of functions. N-Methyl-D-aspartate (NMDA) receptor stimulation which releases nitric oxide and raises cGMP levels, mediates epileptiform activity induced by various agents. Disinhibition of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and/or activation
I, Kaputlu, T, Uzbay
openaire   +2 more sources

Blood pressure variability in established L-NAME hypertension in rats

Journal of Hypertension, 1999
Blood pressure variability was evaluated in conscious Wistar control rats and rats with established L-NAME hypertension (20 mg/kg per 24 h, 4 weeks).Final systolic arterial pressure was 185+/-5 and 132+/-4 mm Hg in the Nomega-nitro-L-arginine methyl ester (L-NAME)-treated and control rats, respectively.
J, Blanc, P, Ponchon, D, Laude, J L, Elghozi, B, Jover   +4 more
openaire   +2 more sources

Effect of post-trial L-NAME administration on cocaine sensitization

International Journal of Neuroscience, 2013
This study determined if Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) administered after the cocaine-conditioning trial attenuated the development of sensitization to cocaine's locomotor-stimulating effect and secondly, determined if L-NAME blocked conditioned-locomotor activity (LMA) elicited by a saline-challenge injection.
Cindy M, Pudiak, Michael A, Bozarth
openaire   +2 more sources

Effect of pioglitazone on l-NAME induced hypertension in diabetic rats

Vascular Pharmacology, 2005
The present study investigates the effect of pioglitazone treatment on blood pressure, vascular reactivity and antioxidant enzymes in L-NAME induced hypertension in normal and STZ-diabetic rats. Diabetes was induced in male Sprague Dawley rats (200+/-15 g) by single intravenous injection of 55 mg/kg of streptozotocin (STZ).
Jayesh B, Majithiya, Arvind N, Parmar, Chitrang J, Trivedi, R, Balaraman   +3 more
openaire   +2 more sources

The effects of atorvastatin on oxidative stress in L-NAME-treated rats

Scandinavian Journal of Clinical and Laboratory Investigation, 2013
Current evidence suggests that the beneficial vascular effects of statins are not limited to the statins' lipid-lowering properties; these drugs can also improve vascular endothelial cell function. Nω-nitro-l-arginine methyl ester (L-NAME) is a potent synthetic nitric oxide inhibitor, and long-term oral L-NAME treatment is used to induce vascular ...
Uzun, Hafize, KAYA, Mehmet, Konukoglu, Dildar, ARICAN, Nadir, TABAK, Omur, Kalayci, Rivase, Gelisgen, Remise, SÖZER, Volkan   +7 more
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L-NAME in the cardiovascular system – nitric oxide synthase activator?

Pharmacological Reports, 2012
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity both in vitro and in vivo, with N(ω)-nitro-L-arginine methyl ester (L-NAME) being at the head. On the one hand, acute and chronic L-NAME treatment leads to changes in blood pressure and vascular reactivity due to decreased nitric oxide (NO) bioavailability. However,
Jana, Kopincová, Angelika, Púzserová, Iveta, Bernátová   +2 more
openaire   +2 more sources

Hypothalamic and Plasmatic Angiotensin Metabolism in L-NAME Treated Rats

Hormone and Metabolic Research, 2010
In order to study the interaction between the renin-angiotensin system (RAS) and nitric oxide (NO), we analyzed the activity of aspartyl- (AspAP), glutamyl- (GluAP), alanyl- (AlaAP), and cystinylaminopeptidase (CysAP) enzymes involved in the RAS cascade, in the hypothalamus, and plasma of normotensive adult male rats after the inhibition of NO ...
A B, Segarra, M, Ramírez, A B, Villarejo, I, Banegas, F, Vives, M, de Gasparo, F, Alba, J, Cobo, I, Prieto   +8 more
openaire   +2 more sources