Results 221 to 230 of about 713,418 (262)

Vasoactive systems in L-NAME hypertension

Journal of Hypertension, 2004
The contribution of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) to blood pressure (BP) maintenance was evaluated in rats with N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension. Furthermore, we studied the extent of nitric oxide (NO) synthesis inhibition and the participation of remaining NO in the ...
Olga, Pechánová, Zdenka, Dobesová, Jakub, Cejka, Jaroslav, Kunes, Josef, Zicha   +4 more
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Carotid Body Remodelling in l-NAME-Induced Hypertension in the Rat

Journal of Comparative Pathology, 2012
The carotid body (CB) is a chemoreceptor organ located at the bifurcation of the common carotid artery. It is made up of the carotid glomus, a structure containing type 1 cells surrounded by type 2 cells. The aim of this study was to evaluate the morphological changes of the CB and carotid glomus in the rat model of l-NAME-induced hypertension.
A S, Felix, V N, Rocha, A L R, Nascimento, J J, de Carvalho   +3 more
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l-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice

Brain Research, 1997
Nitric oxide (NO) formation has been shown in many neuronal tissues subserves a variety of functions. N-Methyl-D-aspartate (NMDA) receptor stimulation which releases nitric oxide and raises cGMP levels, mediates epileptiform activity induced by various agents. Disinhibition of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and/or activation
I, Kaputlu, T, Uzbay
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Blood pressure variability in established L-NAME hypertension in rats

Journal of Hypertension, 1999
Blood pressure variability was evaluated in conscious Wistar control rats and rats with established L-NAME hypertension (20 mg/kg per 24 h, 4 weeks).Final systolic arterial pressure was 185+/-5 and 132+/-4 mm Hg in the Nomega-nitro-L-arginine methyl ester (L-NAME)-treated and control rats, respectively.
J, Blanc, P, Ponchon, D, Laude, J L, Elghozi, B, Jover   +4 more
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Effect of post-trial L-NAME administration on cocaine sensitization

International Journal of Neuroscience, 2013
This study determined if Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) administered after the cocaine-conditioning trial attenuated the development of sensitization to cocaine's locomotor-stimulating effect and secondly, determined if L-NAME blocked conditioned-locomotor activity (LMA) elicited by a saline-challenge injection.
Cindy M, Pudiak, Michael A, Bozarth
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Effect of pioglitazone on l-NAME induced hypertension in diabetic rats

Vascular Pharmacology, 2005
The present study investigates the effect of pioglitazone treatment on blood pressure, vascular reactivity and antioxidant enzymes in L-NAME induced hypertension in normal and STZ-diabetic rats. Diabetes was induced in male Sprague Dawley rats (200+/-15 g) by single intravenous injection of 55 mg/kg of streptozotocin (STZ).
Jayesh B, Majithiya, Arvind N, Parmar, Chitrang J, Trivedi, R, Balaraman   +3 more
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The effects of atorvastatin on oxidative stress in L-NAME-treated rats

Scandinavian Journal of Clinical and Laboratory Investigation, 2013
Current evidence suggests that the beneficial vascular effects of statins are not limited to the statins' lipid-lowering properties; these drugs can also improve vascular endothelial cell function. Nω-nitro-l-arginine methyl ester (L-NAME) is a potent synthetic nitric oxide inhibitor, and long-term oral L-NAME treatment is used to induce vascular ...
Uzun, Hafize, KAYA, Mehmet, Konukoglu, Dildar, ARICAN, Nadir, TABAK, Omur, Kalayci, Rivase, Gelisgen, Remise, SÖZER, Volkan   +7 more
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L-NAME in the cardiovascular system – nitric oxide synthase activator?

Pharmacological Reports, 2012
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity both in vitro and in vivo, with N(ω)-nitro-L-arginine methyl ester (L-NAME) being at the head. On the one hand, acute and chronic L-NAME treatment leads to changes in blood pressure and vascular reactivity due to decreased nitric oxide (NO) bioavailability. However,
Jana, Kopincová, Angelika, Púzserová, Iveta, Bernátová   +2 more
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Hypothalamic and Plasmatic Angiotensin Metabolism in L-NAME Treated Rats

Hormone and Metabolic Research, 2010
In order to study the interaction between the renin-angiotensin system (RAS) and nitric oxide (NO), we analyzed the activity of aspartyl- (AspAP), glutamyl- (GluAP), alanyl- (AlaAP), and cystinylaminopeptidase (CysAP) enzymes involved in the RAS cascade, in the hypothalamus, and plasma of normotensive adult male rats after the inhibition of NO ...
A B, Segarra, M, Ramírez, A B, Villarejo, I, Banegas, F, Vives, M, de Gasparo, F, Alba, J, Cobo, I, Prieto   +8 more
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l-NAME precipitates catatonia during ethanol withdrawal in rats

Behavioural Brain Research, 2001
The effect of N(G)-nitro-L-arginine methyl ester (L-NAME), a non-specific inhibitor of nitric oxide (NO) synthase, on catatonia in ethanol dependent rats was investigated. Ethanol was given to rats by a modified liquid diet. An isocaloric liquid diet without ethanol was also given to control rats. L-NAME (50, 100 and 200 mg/kg) and saline were injected
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