Results 201 to 210 of about 729,292 (310)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling "Negative-Like" Symptoms of Schizophrenia. [PDF]

Biomedicines, 2022
Zemba Cilic A, Zemba M, Cilic M, Strbe S, Ilic S, Vukojevic J, Zoricic Z, Filipcic I, Kokot A, Smoday IM, Rukavina I, Boban Blagaic A, Tvrdeic A, Duplancic B, Stambolija V, Marcinko D, Skrtic A, Seiwerth S, Sikiric P.   +18 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Antihypertensive Effect of a Self-Microemulsifying System Obtained from an Ethanolic Extract of <i>Heliopsis longipes</i> Root in Spontaneously and L-NAME-Induced Hypertensive Rats. [PDF]

Molecules
Marrero-Morfa D, Luz-Martínez BA, Luna-Vázquez FJ, Quirino-Barreda CT, Rojas-Molina I, García-Servín M, Vázquez-Landaverde PA, Ruiz-Castillo V, Ibarra-Alvarado C, Rojas-Molina A.   +9 more
europepmc   +1 more source

L-NAME Administration Enhances Diabetic Kidney Disease Development in an STZ/NAD Rat Model. [PDF]

Int J Mol Sci, 2021
Corremans R, D'Haese PC, Vervaet BA, Verhulst A.   +3 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Pomegranate Juice Alleviates Preeclampsia Symptoms in an L-NAME-Induced Rat Model: A Dose-Dependent Study. [PDF]

Nutrients
Kerdsuknirund S, Thaeomor A, Kupittayanant P, Khunkaewla P, Chanlun S, Srisawat R, Tongdee P, Nimkuntod P, Kupittayanant S.   +8 more
europepmc   +1 more source

Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic l-NAME Treatment in Rats. [PDF]

Biomedicines, 2022
Chao YM, Rauchová H, Chan JYH.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Entrevistando Homens Gays: Espaços do Armário, Protocolos de Sensibilidade e Cuidado Narrativo

Revista Latino-Americana de Geografia e Gênero
L. NAME, O. F. CARRILLO
doaj   +1 more source