ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Role of nitric oxide on the electrophysiological properties of isolated rabbit atrioventricular node by extracellular field potential during atrial fibrillation [PDF]
Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit.
Alizadeh, A.M. +10 more
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ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Quinapril attenuates the effect of long-term L-NAME administration on the vascular reactivity of diabetic rats [PDF]
Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats.
Baluchnejadmojarad, T. +2 more
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Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition [PDF]
In this study, using the microsphere method, the hemodynamic response to endothelin-1 (ET-1) in healthy and streptozotocin (STZ)-diabetic rats was evaluated as well as the influences of inhibition of nitric oxide (NO)-synthase using L-NAME (N omega-nitro-
Sven-Olof Granstam, Elisabet Granstam
core +1 more source
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman +8 more
wiley +1 more source
Curcumin reduces inflammation process in mice model preeclampsia
HIGHLIGHTS • Increased oxidative stress results in increased iNOS in pre-eclampsia. • COX-2 expression in the placenta of women suffering from preeclampsia increases and is associated with increased thromboxane production. ABSTRACT Objective:
Bambang Rahardjo +2 more
doaj +1 more source
Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]
Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw +11 more
core +1 more source
Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle +5 more
wiley +1 more source
Использование дитиокарбаматов при L-NAME индуцированном дефиците оксида азота [PDF]
Рассматриваются эндотелиопротективные свойства синтетических доноров оксида азота, относящихся к группе дитиокарбаматов (RE 1-418, RE 1-419, RE 1-420, OBR 3-121), предоставленных Российским научным центром по антибиотикам, (РНЦА) г ...
Арустамова, А. А. +3 more
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