Results 21 to 30 of about 475,176 (250)

High-yield production of l-serine through a novel identified exporter combined with synthetic pathway in Corynebacterium glutamicum

Microbial Cell Factories, 2020
Background l-Serine has wide and increasing applications in industries with fast-growing market demand. Although strategies for achieving and improving l-serine production in Corynebacterium glutamicum (C.
Xiaomei Zhang, Yujie Gao, Ziwei Chen, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Mattheos A. G. Koffas, Zhenghong Xu   +8 more
doaj   +1 more source

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. [PDF]

PLoS ONE, 2018
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of
Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard   +5 more
doaj   +1 more source

L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury

Frontiers in Molecular Neuroscience, 2021
Central nervous system (CNS) lesions are major causes of human death and disability worldwide, and they cause different extents of motor and sensory dysfunction in patients.
Lisha Ye, Yechao Sun, Zhenglin Jiang, Guohua Wang   +3 more
doaj   +1 more source

Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli

mBio, 2022
Escherichia coli associates with humans early in life and can occupy several body niches either as a commensal in the gut and vagina, or as a pathogen in the urinary tract. As such, E.
Michelle A. Wiebe, John R. Brannon, Bradley D. Steiner, Adebisi Bamidele, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Maria Hadjifrangiskou   +8 more
doaj   +1 more source

ALSUntangled 38: L-serine [PDF]

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2016
Serine is a ‘‘non-essential’’ amino acid which humans can synthesise (2). Serine exists in 2 forms: L-serine and its mirror image D-serine. L-serine is used in making proteins, while D-serine has other roles including acting as a neuromodulator.
openaire   +4 more sources

Biosynthesis of L-Serine Ethanolamine Phosphodiester [PDF]

Nature, 1964
FROM recent work1 it would seem that L-serine ethanol-amine phosphodiester (L-SEP) is found only in the tissues of fish, amphibians, reptiles and birds. D-SEP, on the other hand, appears to be confined to earthworms2, where it is the biological precursor of lombricine3. The status of the work on both isomers has been summarized by Ennor and Rosenberg4.
H, ROSENBERG, A H, ENNOR, S, SUGAI
openaire   +2 more sources

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers. [PDF]

PLoS ONE, 2014
The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer of L-serine, in the serum of patients with severe renal failure, it
Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso   +9 more
doaj   +1 more source

Rational Metabolic Engineering Combined with Biosensor-Mediated Adaptive Laboratory Evolution for l-Cysteine Overproduction from Glycerol in Escherichia coli

Fermentation, 2022
l-Cysteine is an important sulfur-containing amino acid with numerous applications in the pharmaceutical and cosmetic industries. The microbial production of l-cysteine has received substantial attention, and the supply of the precursor l-serine is ...
Xiaomei Zhang, Zhenhang Sun, Jinyu Bian, Yujie Gao, Dong Zhang, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Zhenghong Xu   +9 more
doaj   +1 more source

Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients

Neurobiology of Disease, 2023
L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) signalling.
Anna Di Maio, Tommaso Nuzzo, Luana Gilio, Marcello Serra, Fabio Buttari, Francesco Errico, Arianna De Rosa, Mario Stampanoni Bassi, Micaela Morelli, Jumpei Sasabe, David Sulzer, Manolo Carta, Diego Centonze, Alessandro Usiello   +13 more
doaj   +1 more source

Rubidium pentaaqua(l-serine)cobalt(II) hexahydrogenhexamolybdocobaltate(III) l-serine monosolvate decahydrate

Acta Crystallographica Section E, 2013
The Co2+ ion in the title compound, Rb[Co(C3H7NO3)(H2O)5][H6CoMo6O24]·C3H7NO3·10H2O, is coordinated by five water molecules and one O-monodentate l-serine ligand in a slightly distorted octahedral geometry.
Jun Iijima, Haruo Naruke, Hiroshi Takiyama   +2 more
doaj   +1 more source