Results 111 to 120 of about 139,625 (161)

Methyl-β-Cyclodextrin Impairs the Phosphorylation of the β₂ Subunit of L-Type Calcium Channels and Cytosolic Calcium Homeostasis in Mature Cerebellar Granule Neurons. [PDF]

Int J Mol Sci, 2018
Fortalezas S, Marques-da-Silva D, Gutierrez-Merino C.   +2 more
europepmc   +1 more source

Turtle Flexion Reflex Motor Patterns Show Windup, Mediated Partly by L-type Calcium Channels. [PDF]

Front Neural Circuits, 2017
Johnson KP, Tran SM, Siegrist EA, Paidimarri KB, Elson MS, Berkowitz A.   +5 more
europepmc   +1 more source

Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction. [PDF]

J Neurosci, 2019
Ishii M, Hiller AJ, Pham L, McGuire MJ, Iadecola C, Wang G.   +5 more
europepmc   +1 more source

L-Type Calcium Channels: Structure and Functions

, 2018
Feng, Tianhua, Kalyaanamoorthy, Subha, Barakat, Khaled   +2 more
openaire   +3 more sources

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Assays for L-type voltage gated calcium channels

Analytical Biochemistry, 2022
Voltage gated calcium channels (VGCCs) are pursued as drug targets for neurodegenerative and cardiovascular diseases. High throughput drug screening targeting VGCCs depends on patch-clamp electrophysiology or fluorophore-based calcium imaging that requires powerful equipment and specialized expertise thus leading to cost escalation.
G.M. Archana, R.C. Arunkumar, R.V. Omkumar   +2 more
openaire   +2 more sources

L-Type Calcium Channel Disease

2008
In recent years, the progress of molecular genetics of inherited arrhythmogenic diseases portrays an unexpected complexity of clinical phenotypes associated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of
Ruan Y, Napolitano C, BLOISE, RAFFAELLA, PRIORI, SILVIA GIULIANA   +3 more
openaire   +1 more source

L-Type Calcium Channels: The Low Down

Journal of Neurophysiology, 2004
L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. To establish the contribution of L-type calcium channels to various signaling cascades, investigators have relied on their unique pharmacological sensitivity to dihydropyridines.
Diane, Lipscombe, Thomas D, Helton, Weifeng, Xu   +2 more
openaire   +2 more sources

L-Type Calcium Channels

Current Pharmaceutical Design, 2006
The Ca2+ channel blockers represent a successful group of therapeutic agents directed against cardiovascular targets, including hypertension and angina. These drugs, including the first-generation verapamil, nifedipine and diltiazem are directed against a subclass of voltage-gated Ca2+ channel - the L-type channel.
openaire   +2 more sources

L-Type Calcium Channels Modulation by Estradiol

Molecular Neurobiology, 2016
Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the influx of calcium-and other processes such as gene expression-in excitable cells.
Nelson E, Vega-Vela, Daniel, Osorio, Marco, Avila-Rodriguez, Janneth, Gonzalez, Luis Miguel, García-Segura, Valentina, Echeverria, George E, Barreto   +6 more
openaire   +2 more sources