Cellular Physiology and Biochemistry, 2015 Background/Aims: Arachidonic acid (AA) and its metabolites are important endogenous lipid messengers. In this study, we test the effect of Leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of AA, on L-type calcium channels in A7r5 rat aortic vascular ...
Xiaoyu Liu +4 more
doaj +2 more sources
Increased Calcium Influx through L-type Calcium Channels in Human and Mouse Neural Progenitors Lacking Fragile X Mental Retardation Protein [PDF]
Stem Cell Reports, 2018 Summary: The absence of FMR1 protein (FMRP) causes fragile X syndrome (FXS) and disturbed FMRP function is implicated in several forms of human psychopathology.
Claudia Danesi +9 more
doaj +2 more sources
Neuroprotective effects of blockers for T-type calcium channels [PDF]
Molecular Neurodegeneration, 2009 Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin +4 more
doaj +2 more sources
Structure and function of potassium and calcium channels [PDF]
, 2005 In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
core +7 more sources
T- and L-Type Calcium Channels Maintain Calcium Oscillations in the Murine Zona Glomerulosa. [PDF]
HypertensionBACKGROUND: The zona glomerulosa of the adrenal gland is responsible for the synthesis and release of the mineralocorticoid aldosterone. This steroid hormone regulates salt reabsorption in the kidney and blood pressure.
Dinh HA +4 more
europepmc +2 more sources
Hydrogen sulfide regulates the colonic motility by inhibiting both L-type calcium channels and BKCa channels in smooth muscle cells of rat colon. [PDF]
PLoS ONE, 2015 To examine the hypothesis that hydrogen sulfide (H2S) regulates the colonic motility by modulating both L-type voltage-dependent calcium channels and large conductance Ca2+-activated K+ (BKCa) channels.Immunohistochemistry was performed on rat colonic ...
Xiaojing Quan +5 more
doaj +1 more source
Tissue-specific expression of calcium channels [PDF]
, 1993 The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Flockerzi, Veit +3 more
core +1 more source
P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? [PDF]
, 2002 The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ +11 more
core +1 more source
Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells. [PDF]
PLoS ONE, 2013 INTRODUCTION:WE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses.
Michelle R Rebello +2 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Solanaceae glycoalkaloids (SGAs) possess cardiomodulatory activity.Objective This study investigated the potential interaction between verapamil and glycoalkaloids.Material and methods The cardioactivity of verapamil and glycoalkaloids (α ...
Szymon Chowański +9 more
doaj +1 more source