Results 31 to 40 of about 21,540,161 (247)

Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons

open access: yes, 1992
Modulation of N- and L-type Ca2+ channels by oxotremorine-M (oxo-M) acting on muscarinic receptors and norepinephrine (NE) acting on α-adrenergic receptors was studied in superior cervical ganglion neurons.
Bernheim, L., Mathie, A., Hille, B.
core   +1 more source

The Role of L-type Voltage Gated Calcium Channels in Ovarian Cancer [PDF]

open access: yes, 2021
Ovarian cancer is the most lethal gynaecological malignancy. Of the four ovarian cancer subtypes - serous, mucinous, endometroid and clear cell - serous ovarian cancer is the most common, comprising around 70% of cases.
Luderman, William
core  

L-Type Calcium Channels Modulation by Estradiol

open access: yes, 2017
Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the influx of calcium—and other ...
Osorio, Daniel   +14 more
core   +2 more sources

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons. [PDF]

open access: yesPLoS ONE, 2014
Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy.
Allison Sargoy   +3 more
doaj   +1 more source

The Voltage-Gated Calcium Channel EGL-19 Acts on Glia to Drive Olfactory Adaptation

open access: yesFrontiers in Molecular Neuroscience, 2022
Calcium channelopathies have been strongly linked to cardiovascular, muscular, neurological and psychiatric disorders. The voltage-gated calcium channels (VGCC) are vital transducers of membrane potential changes to facilitate the dynamics of calcium ...
Du Chen   +17 more
doaj   +1 more source

Presynaptic mechanisms determining the dynamic range of neurotransmitter release in the lateral amygdala [PDF]

open access: yes, 2008
The amygdala is a central brain structure receiving sensory information from diverse regions of the central nervous system. Cortical and thalamic axons converge to the lateral amygdala (LA) which is thought to be the main site for fear-induced ...
Fourcaudot, Elodie
core   +1 more source

TRPV5 and TRPV6 calcium-selective channels. [PDF]

open access: yes, 2017
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the ...
Hediger, Matthias   +3 more
core   +2 more sources

Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Cav 2.2) which is ameliorated by quinacrine treatment

open access: yesNeurobiology of Disease, 2004
Prions are transmissible pathogens that cause neurodegenerative diseases, although the mechanisms behind the nervous system dysfunctions are unclear.
Malin K Sandberg   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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