L-Type Calcium Channel C Terminus Autoregulates Transcription [PDF]
Circulation Research, 2009 Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. The guiding hypothesis of this study is that a carboxyl-terminal cleavage product of the cardiac L-type calcium channel (Ca V 1.2) autoregulates expression. First, we confirmed that the Ca
Elizabeth, Schroder +2 more
openaire +2 more sources
Protein kinase A modulation of CaV1.4 calcium channels
Nature Communications, 2016 Phosphorylation of L-type calcium CaV channels by protein kinase A is essential for several physiological events. Here, the authors show how this kinase regulates CaV1.4 activity, suggesting a general regulatory mechanism for all L-type calcium channels.
Lingjie Sang, Ivy E. Dick, David T. Yue
doaj +1 more source
Weft, Warp & Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
Frontiers in Immunology, 2013 Calcium (Ca2+) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation and apoptosis. The events surrounding Ca2+ mobilization in lymphocytes are tightly regulated and involve the coordination of
Kyla D Omilusik +3 more
doaj +1 more source
Tweeters and Woofers: The Complex Orchestra of Calcium Currents in T Lymphocytes
Frontiers in Immunology, 2015 Elevation of intracellular calcium ion (Ca2+) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis.
Lilian L Nohara +12 more
doaj +1 more source
L-type calcium channel auto-regulation of transcription [PDF]
Cell Calcium, 2011 L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus.
Jonathan, Satin +2 more
openaire +2 more sources
Role of T-type calcium channels in myogenic tone of skeletal muscle resistance arteries [PDF]
, 2002 T-type calcium channels may be involved in the maintenance of myogenic tone. We tested their role in isolated rat cremaster arterioles obtained after CO2 anesthesia and decapitation.
Andreasen, Ditte +4 more
core +2 more sources
Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia [PDF]
, 1999 Little is known about the nature of the calcium channels controlling neurotransmitter release from preganglionic parasympathetic nerve fibres. In the present study, the effects of selective calcium channel antagonists and amiloride were investigated on ...
A.B Smith +33 more
core +1 more source
Neuroprotective effects of blockers for T-type calcium channels
Molecular Neurodegeneration, 2009 Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin +4 more
doaj +1 more source
Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]
, 2009 During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan +48 more
core +2 more sources
Psychostimulants, L-type Calcium Channels, Kinases, and Phosphatases [PDF]
The Neuroscientist, 2005 There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression.
Anjali M, Rajadhyaksha +1 more
openaire +2 more sources