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L-Type Calcium Channels Modulation by Estradiol

Molecular Neurobiology, 2016
Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the influx of calcium-and other processes such as gene expression-in excitable cells.
Vega-Vela, Nelson A., Osorio, Daniel, Ávila-Rodriguez, Marco, Gonzalez, Janneth, García-Segura, Luis M., Echeverria, Valentina, Barreto, George E.   +6 more
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Assays for L-type voltage gated calcium channels

Analytical Biochemistry, 2022
Voltage gated calcium channels (VGCCs) are pursued as drug targets for neurodegenerative and cardiovascular diseases. High throughput drug screening targeting VGCCs depends on patch-clamp electrophysiology or fluorophore-based calcium imaging that requires powerful equipment and specialized expertise thus leading to cost escalation.
G.M. Archana, R.C. Arunkumar, R.V. Omkumar   +2 more
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L-Type Calcium Channel Disease

2008
In recent years, the progress of molecular genetics of inherited arrhythmogenic diseases portrays an unexpected complexity of clinical phenotypes associated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of
Ruan Y, Napolitano C, BLOISE, RAFFAELLA, PRIORI, SILVIA GIULIANA   +3 more
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L-Type Calcium Channels: The Low Down

Journal of Neurophysiology, 2004
L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. To establish the contribution of L-type calcium channels to various signaling cascades, investigators have relied on their unique pharmacological sensitivity to dihydropyridines.
Diane, Lipscombe, Thomas D, Helton, Weifeng, Xu   +2 more
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L-Type Calcium Channels

Current Pharmaceutical Design, 2006
The Ca2+ channel blockers represent a successful group of therapeutic agents directed against cardiovascular targets, including hypertension and angina. These drugs, including the first-generation verapamil, nifedipine and diltiazem are directed against a subclass of voltage-gated Ca2+ channel - the L-type channel.
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The Biochemical Properties of L-Type Calcium Channels

Journal of Cardiovascular Pharmacology, 1988
Activation of the cardiac beta-adrenergic receptor stimulates cAMP levels and activates cAMP-dependent protein kinase. The kinase phosphorylates the calcium channel and enhances thereby the availability and the number of channels that are opened during depolarization. The increased calcium influx leads then to a positive inotropic response. The calcium
F, Hofmann, H J, Oeken, T, Schneider, M, Sieber   +3 more
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Interaction of the L-Type Calcium Channel with Calcium Channel Blockers

1996
The contribution of the primary structure and the β subunit to the block of the L-type α1C calcium channel was studied. The α1C-a and the α1C-b subunits were truncated at aa 1733 and 1728, respectively, and were expressed stably in human embryonic kidney (HEK) 293 cells (α1C-at and α1C-bt cell line). The β3 subunit was coexpressed stably with the α1C-a
Franz Hofmann, Norbert Klugbauer, Lubica Lacinová, Claudia Seisenberger, Angela Schuster, Andrea Welling   +5 more
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Regulation of the L-type calcium channel

Trends in Pharmacological Sciences, 1987
Abstract The voltage-operated L-type calcium channel is regulated by protein phosphorylation and G proteins in a variety of tissues and eukaryotes including non-excitable cells. The 165 kDa protein of the dihydropyridine receptor from rabbit skeletal muscle contains all the regulatory sites of an L-type calcium channel and the calcium conducting unit
Franz Hofmann, Wolfgang Nastainczyk, Axel Röhrkasten, Toni Schneider, Manfred Sieber   +4 more
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Molecular Pharmacology of Non-L-type Calcium Channels

Current Pharmaceutical Design, 2005
Voltage-gated calcium channels are key sources of calcium entry into the cytosol. Mutations in calcium channels have been implicated in numerous disorders such as migraine, incomplete congenital X-linked stationary night blindness, epilepsy, and ataxia, and they are important therapeutic targets for the treatment of pain, stroke, hypertension, and ...
Clinton J, Doering, Gerald W, Zamponi
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Osteoblastic cells have L-type calcium channels

Bone and Mineral, 1989
Whole cell patch clamp studies on osteoblast-like rat osteosarcoma cells (ROS 17/2.8) show the existence of L-type calcium channels in the cell membrane. Measurements were carried out at both 21 and 37 degrees C. With isotonic CsCl in the pipette and a bathing medium containing either 110 or 10 mM Ba2+, a strong depolarizing pulse was required to ...
C, Grygorczyk, R, Grygorczyk, J, Ferrier
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