Results 131 to 140 of about 6,477 (171)

Evaluation of Experimental Infection with L. (L.) Amazonensis in X-Linked Immunodeficient Mice

Journal of Parasitology, 2017
B-1 cells are a subtype of B cells with peculiar characteristics. These cells are distinct from B-2 lymphocytes in their morphology, ontogeny, tissue distribution, and phenotypic functional features. B-1 cells can participate in the immune response in several ways, for example, by being recruited to inflammatory foci, producing large amounts of IL-10 ...
Gonzaga, Wagner Francisco Kennerly Marcondes UNIFESP, Geraldo, Mariana Marques UNIFESP, Vivanco, Bruno Camolese UNIFESP, Popi, Ana Flavia UNIFESP, Mariano, Mario UNIFESP, Batista, Wagner Luiz UNIFESP, Xander, Patricia UNIFESP   +6 more
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In vitro efficacy of isoflavonoids and terpenes against Leishmania (Leishmania) infantum and L. amazonensis

Experimental Parasitology, 2022
The main form of control of leishmaniasis is the treatment, however various side effects and poor efficacy are associated with presently available drugs. The investigation of bioactive natural products for new antileishmanial drugs is a valid approach.
Iasmin Aparecida Cunha, Araújo, Renata Cristina, De Paula, Ceres Luciana, Alves, Karen Ferraz, Faria, Marco Miguel de, Oliveira, Gabriela Gonçalves Mendes, Takarada, Eliane Maritns Ferreira Abdias, Dias, Alaíde Braga de, Oliveira, Sydnei Magno da, Silva   +8 more
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Lipidomic alterations of in vitro macrophage infection by L. infantum and L. amazonensis

Molecular BioSystems, 2017
Abstract Particular lipid profiles have been found in two different protozoa of the Leishmania genus. Leishmania infantum, a visceral leishmaniasis causative agent and Leishmania amazonensis, a cutaneous leishmaniasis, reveal distinctive lipid contents of phosphatidylethanolamine and phosphatidylserine plasmalogens, sphingolipids ...
Fernanda Negrão, Daniel R Abánades, Caroline F Jaeeger, Daniele F O Rocha, Katia R A Belaz, Selma Giorgio, Marcos N Eberlin, Célio F F Angolini   +7 more
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ExperimentalLeishmania (L.) amazonensisLeishmaniasis: Characterization and Immunogenicity of Subcellular Fractions

Immunological Investigations, 2007
A technique developed in Trypanosoma cruzi biochemical studies was successfully used to fractionate Leishmania (Leishmania) amazonensis promastigotes. Ultrastructural analyses revealed a membrane fraction (MF) associated to subpellicular microtubules, a ribosomal-rich microsomal fraction (MicF), and a flagellar fraction (FF) free of associated membrane.
T Zaverucha, do Valle, E B, Gaspar, C, Souza-Lemos, C S F, Souza, F B Zamora, Márquez, W, Baetas-da-Cruz, L N, d'Escofier, S, Côrte-Real, K S, Calabrese, S C Gonçalves, da Costa   +9 more
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Inhibition of mouse lymphocyte proliferative response by glycosphingolipids from Leishmania (L.) amazonensis

Experimental Parasitology, 1992
The effect of a purified preparation of glycosphingolipids (GSLs) extracted from Leishmania (L.) amazonensis amastigotes on murine lymphocytes was investigated. GSLs inhibited both concanavalin A (Con A)- or lipopolysaccharide-induced [3H]thymidine uptake by normal and immunized BALB/c mouse lymph node cells. The effect of total GSLs was dose dependent.
S, Giorgio, M G, Jasiulionis, A H, Straus, H K, Takahashi, C L, Barbiéri   +4 more
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Infection of retinal epithelial cells with L. amazonensis impacts in extracellular matrix proteins

Parasitology Research, 2011
One of the manifestations of leishmaniases is eye injuries which main characteristics are the injury of the anterior chamber of the eye and the resistance to specific treatments. The retinal pigment epithelial (RPE) cells participate in pathogen-induced intraocular inflammatory processes.
Calabrese, Katia da Silva, Silva, Leandro de Souza, Pereira Carvalho, Luiz Otavio, Hardoim, Daiana de Jesus, Silva-Almeida, Mariana da, Mortara, Renato Arruda UNIFESP, Freitas de Souza, Celeste da Silva   +6 more
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Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes

Parasitology Research, 1997
Pentamidine-resistant clones of Leishmania donovani and L. amazonensis promastigotes were developed by increase of the drug pressure in the culture medium and characterized. The resistant clones could grow in 40 and 20 microM pentamidine as determined for L. donovani and L.
M, Basselin, F, Lawrence, M, Robert-Gero
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Trypanosoma cruzi P21 protein exacerbates Leishmania (L.) amazonensis infection

Experimental Parasitology
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas disease, affects millions of people worldwide. Current treatments rely on drugs effective only in the acute phase, making the search for new therapeutic targets a priority. While a recombinant protein based on T.
Thaise Lara, Teixeira, Samuel Cota, Teixeira, Bruna Cristina, Borges, João Paulo Silva, Servato, Elida Cristina Monteiro de, Oliveira, Teresiama, Velikkakam, Claudio Vieira da, Silva   +6 more
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Melatonin attenuatesLeishmania (L.) amazonensisinfection by modulating arginine metabolism

Journal of Pineal Research, 2015
AbstractAcute inflammatory responses induced by bacteria or fungi block nocturnal melatonin synthesis by rodent pineal glands. Here, we showLeishmaniainfection does not impair daily melatonin rhythm in hamsters. Remarkably, the attenuated parasite burden and lesion progression in hamsters infected at nighttime was impaired by blockage of melatonin ...
Maria Fernanda, Laranjeira-Silva, Ricardo A, Zampieri, Sandra M, Muxel, Lucile Maria, Floeter-Winter, Regina P, Markus   +4 more
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Assessing the effects of Leishmania (Leishmania) infantum and L. (L.) amazonensis infections in macrophages using a quantitative proteome approach

Experimental Parasitology, 2022
Leishmania (Leishmania) infantum is the causative agent of visceral leishmaniasis, while L. (L.) amazonensis is associated with localized cutaneous and diffuse leishmaniasis, which can affect different organ tissues leading to visceral manifestations in some hosts.
Ivana H.R. Oliveira, Frank Kjeldsen, Marcella N. Melo-Braga, Thiago Verano-Braga, Hélida M. de Andrade   +4 more
openaire   +3 more sources