Results 141 to 150 of about 6,477 (171)

Cloning and characterisation of a cysteine proteinase gene expressed in amastigotes of Leishmania (L.) amazonensis

International Journal for Parasitology, 2003
The present study describes the cloning and characterisation of a gene encoding a cysteine proteinase isoform, Llacys1, expressed in amastigote forms of Leishmania (L.) amazonensis. Recombinant clones containing the Llacys1 gene were isolated from genomic DNA by PCR amplification and screening of an amastigote cDNA library.
Fernanda, Lasakosvitsch, Luciana Girotto, Gentil, Márcia Regina Machado, dos Santos, José Franco, da Silveira, Clara Lúcia, Barbiéri   +4 more
openaire   +2 more sources

Co-infection by Leishmania amazonensis and L. infantum/L. chagasi in a case of diffuse cutaneous leishmaniasis in Bolivia

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2002
We present the first report of a co-infection by Leishmania amazonensis and L. infantum/L. chagasi isolated in 1993 from a patient with diffuse cutaneous leishmaniasis (DCL), living in the sub-Andean region of Bolivia. This is the third reported case of DCL in Bolivia, but the first one with isoenzymatic identification of the aetiological agents ...
E, Martinez, S, Mollinedo, M, Torrez, M, Muñoz, A L, Bañuls, F, Le Pont   +5 more
openaire   +2 more sources

Assessing the composition of the plasma membrane of Leishmania (Leishmania) infantum and L. (L.) amazonensis using label-free proteomics

Experimental Parasitology, 2020
Protozoan parasites of the genus Leishmania are causative agents of leishmaniasis, a wide range of diseases affecting 12 million people worldwide. The species L. infantum and L. amazonensis are etiologic agents of visceral and cutaneous leishmaniasis, respectively.
Ivana H R, Oliveira, Henrique C P, Figueiredo, Cristiana P, Rezende, Thiago, Verano-Braga, Marcella N, Melo-Braga, João Luis, Reis Cunha, Hélida M, de Andrade   +6 more
openaire   +2 more sources

Pravastatin modulates macrophage functions of Leishmania (L.) amazonensis-infected BALB/c mice

Experimental Parasitology, 2013
The control of leishmaniases poses an important challenge due to the scarcity and toxicity of the pharmacological options available. We have previously shown that pravastatin significantly improves the course of the disease in Leishmania (L.) amazonensis-infected BALB/c mice.
Carlos S, Kückelhaus, Selma A S, Kückelhaus, Carlos Eduardo, Tosta, Maria Imaculada, Muniz-Junqueira   +3 more
openaire   +2 more sources

Antileishmanial activity of a naphthoquinone derivate against promastigote and amastigote stages of Leishmania infantum and Leishmania amazonensis and its mechanism of action against L. amazonensis species

Parasitology Research, 2017
Leishmaniasis has become a significant public health issue in several countries in the world. New products have been identified to treat against the disease; however, toxicity and/or high cost is a limitation. The present work evaluated the antileishmanial activity of a new naphthoquinone derivate, Flau-A [2-(2,3,4-tri-O-acetyl-6-deoxy-β-L ...
Débora Vasconcelos Costa Mendonça, Daniela Pagliara Lage, Stephane Lima Calixto, Flaviano Melo Ottoni, Grasiele de Sousa Vieira Tavares, Fernanda Ludolf, Miguel Angel Chávez-Fumagalli, Mônica Santos Schneider, Mariana Costa Duarte, Carlos Alberto Pereira Tavares, Ricardo José Alves, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho   +12 more
openaire   +2 more sources

Differential regulation of dendritic cells migration after L. major and L. amazonensis infection

2018
Leishmaniasis is an endemic disease in tropical and subtropical regions of the world, where it is mainly manifested within mammals. This zoonotic disease is caused by an infection with a protozoan parasite called Leishmania, which resides within the mammal’s macrophages and/or dendritic cells.
openaire   +2 more sources

Morphological alterations and growth inhibition of Leishmania (L.)amazonensis promastigotes exposed to zidovudine (AZT)

Parasitology Research, 2010
Leishmania parasites cause a worldwide public health disease and its treatment is still based on pentavalent antimonials which present financial and toxicologic limitations. Some nucleosidic derivatives have demonstrated anti-leishmanial properties and this study aims to evaluate the in vitro morphologic alterations and growth inhibition of Leishmania (
Carolina A, Araújo, Aline A, Araújo, Camilla L, Batista, Milton A P, Oliveira, Valeria, Oliveira, Ruy S, Lino Junior, Marina C, Vinaud, Jose C B, Bezerra   +7 more
openaire   +2 more sources

A radioiodinated peptidyl diazomethane detects similar cysteine proteinases in amastigotes and promastigotes ofLeishmania (L.) mexicana andL. (L.) amazonensis

Parasitology Research, 1995
Cysteine proteinase activities were examined in lesion amastigotes as well as in stationary-phase promastigotes of Leishmania (L.) mexicana and Leishmania (L.) amazonensis isolates. Enzyme detection in gelatin gels revealed that amastigotes of three L.
S C, Alfieri, J M, Balanco, E M, Pral
openaire   +2 more sources

Lantana camara L. induces a multi-targeted cell death process in Leishmania amazonensis

Journal of Ethnopharmacology
Lantana camara L. is a species known for its broad spectrum of bioactivities and is commonly used in folk therapy to address inflammatory, dermatological, gastrointestinal, intestinal worms and protozoan diseases. It boasts a diverse array of secondary metabolites such as terpenes, flavonoids, and saponins.
Ari Sérgio de Oliveira Lemos, Juliana da Trindade Granato, Luciana Maria Ribeiro Antinarelli, Patrícia de Almeida Machado, Lara Melo Campos, João Pedro Reis Costa Bastos, Victor do Valle Midlej, Adolfo Firmino da Silva Neto, Rodrigo Luiz Fabri, Elaine Soares Coimbra   +9 more
openaire   +2 more sources

Effect of Copaifera reticulata on amastigote forms of Leishmania (L.) amazonensis

Planta Medica, 2008
AO dos Santos, T Ueda-Nakamura, BPD Filho, VF da Veiga Jr, AC Pinto, CV Nakamura   +5 more
openaire   +1 more source