Results 1 to 10 of about 9,297 (211)

Early Suppression of Macrophage Gene Expression by Leishmania braziliensis [PDF]

Frontiers in Microbiology, 2018
Leishmania braziliensis is an intracellular parasite that resides mostly in macrophages. Both the parasite genome and the clinical disease manifestations show considerable polymorphism. Clinical syndromes caused by L.
Nicholas Ettinger, Edgar M Carvalho, Albert Schriefer   +2 more
exaly   +4 more sources

Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND: Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the ...
Sarah A C Falcão, Tiffany Weinkopff, Benjamin P Hurrell, Fabiana S Celes, Rebecca P Curvelo, Deboraci B Prates, Aldina Barral, Valeria M Borges, Fabienne Tacchini-Cottier, Camila I de Oliveira   +9 more
doaj   +2 more sources

Leishmania braziliensis exosomes activate human macrophages to produce proinflammatory mediators [PDF]

Frontiers in Immunology, 2023
Exosomes, organelles measuring 30-200nm, are secreted by various cell types. Leishmania exosomes consist of many proteins, including heat shock proteins, annexins, Glycoprotein 63, proteins exerting signaling activity and those containing mRNA and miRNA.
Fabio C. Peixoto, Fabio C. Peixoto, Dalila L. Zanette, Thiago M. Cardoso, Mauricio T. Nascimento, Mauricio T. Nascimento, Rodrigo C. O. Sanches, Mateus Aoki, Phillip Scott, Sérgio C. Oliveira, Sérgio C. Oliveira, Edgar M. Carvalho, Edgar M. Carvalho, Edgar M. Carvalho, Lucas P. Carvalho, Lucas P. Carvalho, Lucas P. Carvalho   +16 more
doaj   +2 more sources

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000-2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis. [PDF]

Zoonoses Public Health
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Miranda LFC, Coelho LFDR, Xavier SCDC, Junior AAVM, Albuquerque RN, da Silva AF, Marcelino AP, Santos FN, Pereira SA, Menezes RC, Schubach AO.   +10 more
europepmc   +2 more sources

Genomic Diversification, Structural Plasticity, and Hybridization in Leishmania (Viannia) braziliensis

Frontiers in Cellular and Infection Microbiology, 2020
Leishmania (Viannia) braziliensis is an important Leishmania species circulating in several Central and South American countries. Among Leishmania species circulating in Brazil, Argentina and Colombia, L. braziliensis has the highest genomic variability.
Luz H Patino, Marina Munoz, Lissa Cruz-Saavedra   +2 more
exaly   +3 more sources

Potential vectors of Leishmaniases in the Environmental Protection Area and Tinguá Federal Biological Reserve, Municipality of Nova Iguaçu, Rio de Janeiro, Brazil. [PDF]

Med Vet Entomol
This study was to describe the composition of sand fly fauna, detect potential vectors of Leishmania spp. in the Tinguá district, an ATL endemic, Rio de Janeiro, Brazil. Seven species of vectorial importance in the epidemiological cycle of leishmaniasis was observed: Nyssomyia intermedia, Migonemyia migonei, Pintomyia fischeri, Psychodopygus hirsutus ...
Santana ALF, Azevedo ACR, Afonso MMS, Carvalho BM, Vieira VR, Costa SM, Silva JS, Pereira TA, Pereira DP, Vilela ML.   +9 more
europepmc   +2 more sources

Unveiling the Leishmanicidal Mechanism of 4-Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum. [PDF]

Chem Biodivers
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Lorenzetti FB, Balbinot RB, Lazarin-Bidóia D, Faiões VDS, Torres-Santos EC, Nakamura CV, Ueda-Nakamura T, Garcia Cortez DA, Dias Filho BP.   +8 more
europepmc   +2 more sources

Modulation of fibroblast behavior by Leishmania: a pathway to understanding disease progression in cutaneous leishmaniasis [PDF]

BMC Microbiology
Leishmaniasis is a parasitic infection caused by obligatory intracellular protozoa of the Leishmania genus. Macrophages are the main cell for Leishmania parasites that play a key role in immune response against it.
Tarcisio Navegante de Queiroz Filho, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +2 more
doaj   +2 more sources

The heterologous expression of Escherichia coli MutT enzyme is involved in the protection against oxidative stress in Leishmania braziliensis [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND Oxidative stress is responsible for generating DNA lesions and the 8-oxoguanine (8-oxoG) is the most commonly lesion found in DNA damage. When this base is incorporated during DNA replication, it could generate double-strand DNA breaks and ...
Laila de Carvalho Andrade, Ana Maria Murta Santi, Ceres Luciana Alves, Wesley Roger Rodrigues Ferreira, Antônio Vinícius de Assis, Edward Oliveira, Carlos Renato Machado, Silvane Maria Fonseca Murta   +7 more
doaj   +2 more sources

The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis. [PDF]

PLoS ONE, 2016
Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, presents an exaggerated Th1 response that is associated with ulcer development. Macrophages are the primary cells infected by Leishmania parasites and both reactive oxygen species (ROS)
Pedro Paulo Carneiro, Jacilara Conceição, Michael Macedo, Viviane Magalhães, Edgar M Carvalho, Olivia Bacellar   +5 more
doaj   +1 more source