Results 21 to 30 of about 9,297 (211)

Chemotherapeutic potential of 17-AAG against cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: Leishmaniasis remains a worldwide public health problem. The limited therapeutic options, drug toxicity and reports of resistance, reinforce the need for the development of new treatment options.
Diego M Santos, Antonio L O A Petersen, Fabiana S Celes, Valeria M Borges, Patricia S T Veras, Camila I de Oliveira   +5 more
doaj   +1 more source

Prostaglandin E2 contributes to L. braziliensis survival and therapeutic failure in cutaneous leishmaniasis

Emerging Microbes & Infections, 2023
Patients with cutaneous leishmaniasis (CL) present an exacerbated inflammatory response associated with tissue damage and ulcer development. In recent years, higher rates of failure to pentavalent antimoniate therapy have been observed, yet the underlying reason remains poorly understood.
Maurício T. Nascimento, Débora L. Viana, Fábio C. Peixoto, Sérgio M. Arruda, Edgar M. Carvalho, Lucas P. Carvalho   +5 more
openaire   +3 more sources

L. braziliensis genomic variants.

, 2023
Frame-shift and missense variants enriched in L. braziliensis parasites present in Northeast Brazil. (XLSX)
Elise Krespan (11565500), Matthew W. Mitchell (14817749), Jane A. Yu (3123150), Christina K. Go (14817755), Clara R. Malekshahi (14817752), Alexander S. F. Berry (6714761), Phillip Scott (268925), Camila F. Amorim (14817764), Cooper A. Grace (9706425), Daniel C. Jeffares (11362095), Lucas P. Carvalho (9250841), Edgar M. Carvalho (6657776), Dustin Brisson (210833), Daniel P. Beiting (7329887), Alexsandro S. Lago (10515938), Olivia A. Pilling (14817746), João L. Reis-Cunha (3123534), Cláudia Lombana (14817758), Yun S. Song (14817761)   +18 more
core   +1 more source

Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-α production

BMC Infectious Diseases, 2010
Background Nitric oxide (NO) produced in macrophages plays a pivotal role as a leishmanicidal agent. A previous study has demonstrated that 20% of the L. (V.) braziliensis isolated from initial cutaneous lesions of patients from the endemic area of Corte
Wilson Mary E, de Moura Tatiana R, de Jesus Amelia R, Guimarães Luís H, Pereira Júlia MB, Giudice Angela, Souza Anselmo S, Carvalho Edgar M, Almeida Roque P   +8 more
doaj   +1 more source

Minor temperature shifts do not affect chromosomal ploidy but cause transcriptomic changes in Leishmania braziliensis promastigotes in vitro [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND The leishmaniases are complex neglected diseases caused by protozoan parasites of the genus Leishmania. Leishmania braziliensis is the main etiological agent of cutaneous leishmaniasis in the New World. In recent studies, genomic changes such
Nathalia Ballesteros, Nubia M Vásquez, Luz H Patiño, Lissa Cruz-Saavedra, Juan David Ramírez   +4 more
doaj   +1 more source

Annexin A1 downregulates <i>in vitro</i> IL-1<i>β</i> production in <i>L. braziliensis</i>-infected cells. [PDF]

Front Immunol
Cutaneous leishmaniasis (CL) is an infectious disease characterized by severe local inflammatory response, predominantly mediated by cytokines such as IL-1 β and TNF, and cytotoxicity, contributing to tissue damage and lesion development. Given the high rate of therapeutic failure in
Santos CP, Nascimento MT, Santana MBR, Carvalho EM, Carvalho LP.   +4 more
europepmc   +4 more sources

Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters. [PDF]

PLoS ONE, 2014
Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model.
Luciana Costa, Roberta O Pinheiro, Patrícia M L Dutra, Rosiane F Santos, Edézio F Cunha-Júnior, Eduardo C Torres-Santos, Alcides J M da Silva, Paulo R R Costa, Silvia A G Da-Silva   +8 more
doaj   +1 more source

Identification of cytoplasmic soluble antigens related to the major surface antigens ofLeishmania braziliensis braziliensis andL. donovani chagasi

Parasitology Research, 1990
This study describes the identification of aqueous-soluble antigens in Leishmania promastigotes immunologically and biochemically closely related to the major surface antigen. Proteins from surface-iodinated L. braziliensis braziliensis and L. donovani chagasi promastigotes, extracted and separated by partitioning in the detergent Triton X-114, were ...
Kutner, S., Pellerin, Patrice, Breniere, S.F.   +2 more
openaire   +4 more sources

Study of the differentially abundant proteins among Leishmania amazonensis, L. braziliensis, and L. infantum

PLOS ONE, 2020
Leishmaniasis has been considered as emerging and re-emerging disease, and its increasing global incidence has raised concerns. The great clinical diversity of the disease is mainly determined by the species. In several American countries, tegumentary leishmaniasis (TL) is associated with both Leishmania amazonensis and L.
Bruna Soares de Souza Lima, Barbara Beiral Esteves, Luiz Carlos Fialho-Júnior, Tiago Antônio de Oliveira Mendes, Simone da Fonseca Pires, Alexander Chapeourouge, Jonas Perales, Helida Monteiro de Andrade   +7 more
openaire   +4 more sources

Dogs Harbor Leishmania braziliensis and Participate in the Transmission Cycle of Human Tegumentary Leishmaniasis

Pathogens, 2023
Dogs play an important role in transmission of Leishmania infantum, but epidemiologic and clinical studies of canine tegumentary leishmaniasis (CTL) are scarce.
Jamile Lago, Deborah Fraga, Lívia Coelho, Matheus Silva de Jesus, Bruna Leite, Guilherme L. Werneck, Sérgio Arruda, Ednaldo Lago, Edgar M. Carvalho, Olivia Bacellar   +9 more
doaj   +1 more source