Results 71 to 80 of about 178 (92)
ChemInform, 1999 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kollol Pal +3 more
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Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
International Journal of Oncology, 1996 Flavopiridol is a new synthetic flavone, structurally related to a natural alkaloid, originally purified from Dysoxylum binectariferum, a plant indigenous to India and used in Indian folk medicine. Flavopiridol was detected by a tandem screening system consisting in inhibition of the EGF-receptor Tyrosine phosphokinase and cytotoxicity. As a cytostatic
M Losiewicz +10 more
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Long-term outcome of L86 and L97 protocols for adult acute lymphoblastic leukemia
Leukemia & Lymphoma, 2008 We analysed the long-term outcome of the L86 protocol using L-asparaginase (L-asp), vincristine (VCR) and prednisolone (PSL), collectively known as LVP or L97 protocol using LVP along with pirarubicin hydrochloride (THP-ADR) for 97 patients with acute lymphoblastic leukemia (ALL) diagnosed between 1986 and 2002.
Yoshiaki Ishigatsubo +15 more
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Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275
Biochemical and Biophysical Research Communications, 1994 L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.
Michael D. Losiewicz +4 more
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Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275
JNCI Journal of the National Cancer Institute, 1992 Previous studies have shown that polyhydroxylated flavonoids such as quercetin and genistein can inhibit tumor cell growth in vitro, and preliminary in vivo studies of the flavone L86-8275 have shown growth inhibition of LX529 and A549 lung carcinomas.
Ramachandra Naik +8 more
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, 2023 This product includes information on the manufacturer, engine, application, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
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Biochemical Pharmacology, 1993 The flavone L86-8275 [(-)cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-[4-(3-hydroxy-1-methyl)- piperidinyl]-4H-1-benzopyran-4-one] delayed the progression of aphidicolin-synchronized MDA-468 breast carcinoma cells through S phase and prevented progression through G2.
Gurmeet Kaur +5 more
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Cancer Chemotherapy and Pharmacology, 1998 Flavopiridol is a flavone which inhibits several cyclin-dependent kinases, and exhibits potent growth-inhibitory activity against a number of human tumor cell lines both in vitro, and when grown as xenografts in mice. It is currently being evaluated in a phase I clinical trial at the National Cancer Institute.
Lawrence R. Phillips +4 more
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, 2023 This product includes information on the manufacturer, engine, applications, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
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J1349 Certified Power Engine Data for GM L86/L87 as used in 2019 T1xx - 93 Octane - Level 1
, 2023 This product includes information on the manufacturer, engine, application, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire +2 more sources