Results 81 to 90 of about 3,064,884 (271)

Research on the Construction of Learning Health System in China [PDF]

中国工程科学
The health system in China has progressed to a new phase of development; however, it continues to face challenges such as uneven distribution of resources and insufficient coordination among service sectors.
Xi Li, Yang Yang, Mingming Su, Shijun Gao, Bolin Jin, Shengshou Hu   +5 more
doaj   +1 more source

Optimizing end-labeled free-solution electrophoresis by increasing the hydrodynamic friction of the drag-tag

, 2009
We study the electrophoretic separation of polyelectrolytes of varying lengths by means of end-labeled free-solution electrophoresis (ELFSE). A coarse-grained molecular dynamics simulation model, using full electrostatic interactions and a mesoscopic ...
Ahlrichs P., Cottet H., Deserno M., Desruisseaux C., Dünweg B., Dünweg B., Grass K., Grass K., Grosser S. T., Haynes R. D., Heller C., Hoagland D. A., Hsiao P.-Y., Hu S., Kan C. W., Limbach H. J., Lobaskin V., Lobaskin V., Lobaskin V., Long D., Manning G. S., McCormick L. C., McCormick L. C., McCormick L. C., McCormick L. C., McNamara G. R., Meagher R. J., Meagher R. J., Mohanty U., Muthukumar M., Nedelcu S., Nedelcu S., Ren H., Savard J. M., Savard J. M., Slater G. W., Soddemann T., Stellwagen E., Ullner M., Viovy J. L., Volkel A. R., Vreeland W. N., Weeks J. D., Wolff U.   +43 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Development Achievements and Future Prospects of Advanced Rail Transit Equipment [PDF]

中国工程科学
Advanced rail transit equipment is crucial for boosting China's strength in manufacturing and transportation development. Considering global technological evolution directions of rail transit equipment and based on the landscape and high-quality ...
Rongjun Ding, Kean Liu, Jun Wang, Yuebin Yu, Jianying Liang, Liang Han, Xiangmeng Meng   +6 more
doaj   +1 more source

Robust Loss Functions under Label Noise for Deep Neural Networks

, 2017
In many applications of classifier learning, training data suffers from label noise. Deep networks are learned using huge training data where the problem of noisy labels is particularly relevant. The current techniques proposed for learning deep networks
Ghosh, Aritra, Kumar, Himanshu, Sastry, P. S.   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Development Strategy for Intelligent Resilience of Underground Space System in Megacities [PDF]

中国工程科学
The development of underground spaces in megacities is crucial for alleviating urban land pressure, optimizing transportation, and enhancing resilience.
Kaihang Han, Junxuan Li, Xiangsheng Chen, Yinfu Jin, Xingtao Lin, Nan Zhang, Xi Chen, Dong Su, Xiaohua Bao, Hongzhi Cui   +9 more
doaj   +1 more source

U.S. Retailers: Responsible for the Global Sweatshop Crisis [PDF]

, 2001
This report provides an overview of the global sweatshop system, and offers a closer look at some of the more “prominent perpetrators” within the system, including: Ann Taylor, Abercrombie & Fitch, Eddie Bauer, Gap, Old Navy, Banana Republic, and J ...
Behind the Label (UNITE HERE)
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

High-end, Intelligent, Green, and Integrated: Strategic Directions and Technological Pathways for the Innovative Development of China's Manufacturing Industry [PDF]

中国工程科学
Manufacturing is the lifeblood of a country’s economy, as well as the cornerstone of a nation. China has formulated and advanced a national strategy of new-type industrialization and a three-step roadmap for boosting China’s strength in manufacturing ...
Ji Zhou, Gaofeng Zhu, Liheng Wang, Hequan Wu, Yong Gan, Peigen Li, Zhihua Zhong, Zhongqin Lin, Zheng You, Jianfeng Chen, Xuedong Chen, Haibin Yu, Huayong Yang, Shuxin Wang, Guoqing Wang, Qingxue Huang, Xin Chen, Hong Yang, Xianming Qu, Yanhong Zhou, Jiyuan Zang   +20 more
doaj   +1 more source