Results 71 to 80 of about 2,914,902 (352)

Evaluation of Biomarkers of Exposure in Smokers Switching to a Carbon-Heated Tobacco Product: A Controlled, Randomized, Open-Label 5-Day Exposure Study

Nicotine & Tobacco Research, 2016
Introduction: Tobacco harm reduction aims to provide reduced risk alternatives to adult smokers who would otherwise continue smoking combustible cigarettes (CCs).
F. Lüdicke, C. Haziza, R. Weitkunat, J. Magnette   +3 more
semanticscholar   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

A label-free thrombin photoelectrochemical aptasensor based on structure-switching in G-quadruplexes

Biosensors and Bioelectronics: X, 2022
In this work, an Au/GaN photoelectrode was prepared by sputtering a 30.0-nm–thick gold film on an n-type gallium nitride (GaN) surface. Guanine (G) was used as a hole trap in photoinduced charge separation due to its lowest oxidation potential and ...
Xiujun Rong, Huilan Zhang, Weicheng Cai, Fang Luo, Cuiying Lin, Bin Qiu, Zhenyu Lin, Jian Wang, Zhou Jiang, Hui Huang   +9 more
doaj   +1 more source

Simulasi Multi Protocol Label Switching Virtual Private Network (MPLS VPN) Dengan Virtual Local Area Network (VLAN) Menggunakan Router MIKROTIK [PDF]

, 2018
Untuk mendapatkan komunikasi yang cepat, aman, dan mudah diakses digunakan jaringan MPLS VPN menggunakan VLAN. Jaringan MPLS akan mengirimkan paket sesuai dengan label yang ada pada header paket ke tujuan yang diinginkan dan VPN akan membatasi siapa ...
Euginia, B. (Bertha), Ghozali, T. (Theresia)   +1 more
core  

Motivation crowding in real consumption decisions: Who is messing with my groceries? [PDF]

, 2014
We present evidence of crowding out of intrinsic motivation in real purchasing decisions from a field experiment in a large supermarket chain. We compare three instruments, a label, a subsidy and a neutral price change, in their ability to induce ...
Andreoni, Andreoni, Arce, Ariely, Bem, Bhapkar, Bjørner, Bowles, Bowles, Bénabou, Charness, Chetty, Corgnet, Deci, Eckel, Ellingsen, Falk, Fehr, Fehr, Frey, Frey, Frey, Frey, Frohlich, Gneezy, Gneezy, Goeschl, Harrison, Heyes, Heyman, Kahneman, Kallbekken, Meier, Meier, Mellström, Noussair, Schnedler, Sliwka, UK Office for National Statistics.   +38 more
core   +1 more source

Optical label switching

Optical Fiber Communication Conference and International Conference on Quantum Information, 2001
Summary form only given. The design and implementation of a optical label switched router for packet switched WDM networks will be presented. The algorithms of generating optical labels, look-up tables, routing protocols, and a scaleable network architecture similar to IP/MPLS in optical domain will also be discussed.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Badanie możliwości i ograniczeń zarządzania ruchem sieciowym z wykorzystaniem protokołu MPLS we współczesnych sieciach teleinformatycznych [PDF]

Zeszyty Naukowe Warszawskiej Wyższej Szkoły Informatyki, 2016
W artykule przedstawiono technologię MPLS (ang. MultiProtocol Label Switching), która reprezentuje nowy poziom w rozwoju standardów wykorzystywanych w połączeniach technologii przełączania warstwy drugiej modelu odniesienia ISO/OSI z technologią routingu
Dariusz Chaładyniak, Maciej Podsiadły
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source