Results 91 to 100 of about 1,573,361 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multiple etiologies of infectious diarrhea and concurrent infections in a pediatric outpatient-based screening study in Odisha, India

Gut Pathogens, 2017
Background There are multiple etiologies responsible for infectious gastroenteritis causing acute diarrhea which are often under diagnosed. Also acute diarrhea is one of the major causes of morbidity and mortality among children less than 5 years of age.
Arpit Kumar Shrivastava, Subrat Kumar, Nirmal Kumar Mohakud, Mrutyunjay Suar, Priyadarshi Soumyaranjan Sahu   +4 more
doaj   +1 more source

Future treatments for hereditary hemorrhagic telangiectasia

Orphanet Journal of Rare Diseases, 2020
Hereditary Hemorrhagic Telangiectasia (HHT), also known as Rendu-Osler syndrome, is a genetic vascular disorder affecting 1 in 5000–8000 individuals worldwide.
Florian Robert, Agnès Desroches-Castan, Sabine Bailly, Sophie Dupuis-Girod, Jean-Jacques Feige   +4 more
doaj   +1 more source

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract [PDF]

, 2014
This work was supported by a Royal Society (London) University Research Fellowship (to JPS), by Biotechnology and Biological Sciences Research Council (UK) grants BB/K009664/1 (to JPS, AK, and GHL) and BB/K009737/1 (CDB and LB), US Public Health Service ...
Leeming, G H, Moyo, NA, Bingle, Colin D, Bigley, A.L., Tripp, Ralph A, Bennett, E., Hughes, D J, Leeming, G.H., Moyo, N A, Bingle, L, Bigley, AL, Sample, JT, Bigley, Alison L, Bigley, A L, Tripp, R A, Sample, J T, Kipar, A, Moyo, Nathifa A, Stewart, JP, Stewart, J.P., Bennett, E, Tripp, R.A., Hughes, DJ, Kipar, A., Tripp, RA, Stewart, James P, Bingle, Lynne, Bennett, Elaine, Hughes, D.J., Leeming, Gail H, Sample, Jeffery T, Bingle, C D, Leeming, GH, Moyo, N.A., Sample, J.T., Moyo, Nathifa, Hughes, David J, Kipar, Anja, Bingle, CD, Bingle, L., Bingle, C.D., Stewart, J P   +41 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessment of knowledge, attitude, and practice regarding safety laboratory measures during COVID-19 pandemic – A cross-sectional study among oral pathologists in Kerala

Journal of Indian Association of Public Health Dentistry, 2022
Plakkil Viswanathan Deepthi, P M Shameena, Sujatha Varma, M N Navajeevraj   +3 more
doaj   +1 more source

Association Between Toxoplasma gondii Infection and Serum Neurotransmitter Levels in Major Depressive Disorder Patients: A Case-Control Study in Bangladesh

Journal of Parasitology Research
Toxoplasma gondii (T. gondii) is an obligate, intracellular, neurotropic protozoan parasite. After primary infection, T. gondii parasite undergoes stage conversion from fast-replicating tachyzoites to slow-replicating dormant bradyzoites, particularly in
Jerin E. Gulshan, Samia Sultana Lira, M. M. A. Shalahuddin Qusar, Md. Ismail Hosen, Atiqur Rahman, Md. Rabiul Islam, Taibur Rahman   +6 more
doaj   +1 more source

Laboratory diagnosis approaches of COVID-19 infection

One Health & Risk Management, 2021
Introduction. The coronavirus disease 2019 (COVID-19), is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2. The COVID‑19 pandemic has forced the scientific community to rapidly develop highly reliable diagnostic methods in
Ibrahim Ahmad HUJEIRAT
doaj  

Development of methods for detection and eradication of mouse parvovirus from a laboratory mouse colony

, 2007
The mouse parvovirus designated MPV can infect laboratory mice and affect the humoral and cellular immune response of infected mice, reducing their value for biomedical and medical research.
Filipovska-Naumovska, Emilija
core  

Primary HIV-1 Infection Among Infants in sub-Saharan Africa: HPTN 024. [PDF]

, 2009
Our objectives were to assess clinical signs and diagnoses associated with primary HIV-1 infection among infants. We analyzed data from a clinical trial (HIV Prevention Trials Network Protocol 024) in sub-Saharan Africa.
Read, Jennifer S, Manji, Karim, Taha, T.E., Manji, K., Richardson, B., Valentine, Megan, Goldenberg, R.L., Emel, Lynda, Sharma, U., Read, J.S., Taha, Taha E, Valentine, M., Sharma, Usha, Mwatha, Anthony, Richardson, Barbra, Goldenberg, Robert L, Mwatha, A., Hoffman, I., Emel, L., Hoffman, Irving   +19 more
core   +1 more source