Results 111 to 120 of about 1,573,361 (315)

Laboratory Diagnosis of HIV Infection

Emergency Medicine Clinics of North America, 1991
Laboratory diagnosis of human immunodeficiency virus (HIV) infection is complicated by absence of data on sensitivity, specificity and predictive value of the various tests as they apply to children. The presence of maternal anti-HIV passively transmitted across the placenta also confounds diagnosis.
K, Krasinski, W, Borkowsky
openaire   +2 more sources

Mycobacterium tuberculosis: assessing your laboratory [PDF]

The number of people with active tuberculosis in the United States steadily increased from 1985 until 1992. The population groups in the United States that are at increased risk for infection with M.
Association of State and Territorial Public Health Laboratory Directors (U.S.)
core  

Chlamydia psittaci infection in canaries heavily infested by Dermanyssus gallinae [PDF]

, 2011
Dermanyssus gallinae is a haematophagous ectoparasite responsible for anemia, weight loss, dermatitis and a decrease in egg production. Dermanyssus gallinae may play a role in the modulation of the host immune system, maybe predisposing the host to some ...
Camarda, A., A. Camarda, Pugliese, Nicola, Camarda, Antonio, Circella, Elena, Sparagano, O. A E, Pugliese, N., Cafiero, M. A., Sparagano, Olivier, Elena Circella, G. Todisco, N. Pugliese, Cafiero, Ma, Sparagano, Oae, M. A. Cafiero, O. A. E. Sparagano, Todisco, G, Todisco, G., Cafiero, Maria Assunta, Todisco, Gianluca   +19 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? [PDF]

, 2010
Background: Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses.
Jochen Steinmann, Rapp, Ingrid, Ingrid Rapp, Rabenau, Holger, Steinmann Jochen, Holger F Rabenau, Steinmann, Jochen, Rabenau Holger F, Rapp Ingrid   +8 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

[Laboratory infections].

Mikrobiyoloji bulteni, 1993
Infection constitutes an important professional hazard for health care workers. Since the past decades infections acquired during laboratory work have caused morbidity and even mortality among laboratory employees. In this article the importance of laboratory acquired infections and some guidelines for protection are stated.
openaire   +1 more source

The Role of Varicella Zoster Virus (VZV) in Central Nervous System Infectious Syndromes

Canadian Journal of Infectious Diseases and Medical Microbiology
Conclusions: VZV is a significant cause of viral CNS infections. In the majority of patients with neurologic syndrome and evident VZV there is no association with a typical herpetic rash.
Viktoria Yakovenko, Pnina Ciobotaro, Rita Bardenstein, Margalit Zusev, Oren Zimhony   +4 more
doaj   +1 more source