Results 31 to 40 of about 16,154 (262)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

'n Alternatiewe model vir arbeidsbetrekkinge in Suid-Afrika

South African Journal of Business Management, 1977
The need for a review of the industrial relations system in South Africa is confirmed by an analysis of the motives underlying the 1973 strikes indicating that (a) a need for job security, expressed as assurance against arbitrary management action, and ...
Dawie de Villiers
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Queensland’s kidnapping Act: the Native Labourers Protection Act of 1884

Aboriginal History Journal, 2011
The events leading to the passage of the Native Labourers Protection Act in 1884 are presented. The Act was actually passed to control abuses in the recruitment of Pacific Islanders in the fishing industry in Queensland, but was not applied to improve recruitment practices or working conditions of the Aborigines.
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Labour Law of the European Communities in the Czech Labour law after Recodification of the Labour Code

Časopis pro Právní Vědu a Praxi, 2008
The labour law of the European Community was reflected in the Czech labour law at the time when the Czech Republic was preparing for its accession to the European Community by means of fundamental and extensive amendments of the then Labour Code, i.e ...
Zdeňka Gregorová
doaj  

Employment Casualisation Challenges and Trade Union Responses: Implication for Decent Work in Nigeria’s Beverage Sector

International Journal of Applied Research in Business and Management
The study examines the challenges of employment casualization and the responsiveness of labour union to employment casualization in Nigeria’s beverage sector. The mixed method research was employed with 846 participants recruited from 5 selected beverage
Samson Adewumi
doaj   +1 more source

ILO and the International Labour Standards Setting: A Case of Nigeria Labour Acts [PDF]

Journal of Human Resource Management, 2013
This study examines how International Labour Organisation set-up a labour conventions and the role Nigeria government play in using these conventions to create National Labour Acts. The idea was critically investigated to measure the effect of such labour standards in Nigeria that adopted the convention, while the weakness on the part of Ministry of ...
openaire   +1 more source