Results 61 to 70 of about 37,884 (225)

DNA looping: the consequences and its control [PDF]

, 2006
The formation of DNA loops by proteins and protein complexes is ubiquitous to many fundamental cellular processes, including transcription, recombination, and replication.
Ackers, Adhya, Alberts, Becker, Bloomfield, Broach, Cloutier, de Lange, Dodd, Du, Dunn, Halford, Hanke, Hill, Irani, Jose MG Vilar, Knight, Leonor Saiz, Lewis, Li, Matthews, Moreau, Mossing, Muller, Müller-Hill, Oehler, Olson, Ptashne, Ptashne, Radman-Livaja, Revet, Richmond, Ringrose, Rippe, Saiz, Saiz, Schleif, Semsey, Stenger, Tolhuis, Vilar, Vilar, Villa, Yan, Yasmin, Zhang   +45 more
core   +1 more source

From Binary to Multivalued to Continuous Models: The lac Operon as a Case Study

Journal of Integrative Bioinformatics, 2010
Using the lac operon as a paradigmatic example for a gene regulatory system in prokaryotes, we demonstrate how qualitative knowledge can be initially captured using simple discrete (Boolean) models and then stepwise refined to multivalued logical models ...
Franke Raimo, Theis Fabian J., Klamt Steffen   +2 more
doaj   +2 more sources

The Role of Integration Host Factor in Escherichia coli Persister Formation

mBio, 2022
Persisters represent a small subpopulation of cells that are tolerant of killing by antibiotics and are implicated in the recalcitrance of chronic infections to antibiotic therapy.
Samantha E. Nicolau, Kim Lewis
doaj   +1 more source

Bistable behavior of the lac operon in E. coli when induced with a mixture of lactose and TMG

Frontiers in Physiology, 2010
In this work we investigate multistability in the lac operon of Escherichia coli when it is induced by a mixture of lactose and the non-metabolizable thiomethyl galactoside (TMG).
Orlando Díaz-Hernández, Orlando Díaz-Hernández, Moisés Santillán, Moisés Santillán   +3 more
doaj   +1 more source

Suppression and enhancement of transcriptional noise by DNA looping [PDF]

Phys. Rev. E 89, 062703 (2014), 2014
DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping.
arxiv   +1 more source

Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [PDF]

, 2019
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself.
Casadesús Pursals, Josep, García Pastor, Lucía, Jakomin, Marcello, Puerta Fernández, Elena, Sánchez Romero, María Antonia   +4 more
core   +1 more source

Phenotypic Variation and Bistable Switching in Bacteria [PDF]

, 2008
Microbial research generally focuses on clonal populations. However, bacterial cells with identical genotypes frequently display different phenotypes under identical conditions.
A Becskei, A Becskei, A Guerrero, A Johnson, A Khlebnikov, A Khlebnikov, A Khlebnikov, A Lipshtat, A Moter, A Novick, AE Merode van, AE Merode van, AE Tsong, B Muller-Hill, B Slutsky, BB Magee, BE Laue, BF Brehm-Stecher, BJ Haijema, C Hadden, C Wiuff, CM Hull, CM Hull, CM Southward, CY Lan, D Angeli, D Dubnau, D Dubnau, D Dubnau, D Kidane, D Sinderen van, D Sinderen van, DB Kearns, DC Dooley, DH Dean, DR Soll, E Korobkova, E Kussell, EH Rikkerink, EJ Stewart, EM Ozbudak, EM Ozbudak, ER Sumner, EW Nester, F Jacob, F Joux, F Ortega, F Russo-Marie, FH Cahn, FH Kasten, FJ Isaacs, G Huang, G Nebe-von-Caron, GM Suel, GM Suel, H Kobayashi, H Maamar, H Makinoshima, H Steinmoen, H Steinmoen, HB Fraser, HM Davey, I Golding, I Golding, I Hautefort, IR Henderson, J Casadesus, J Hahn, J Hahn, J Hasty, J Hasty, J Holtzendorff, J Kreth, J Monod, J Vidal-Mas, J Vives-Rego, J Zieg, JD Chung, JD Chung, JD Chung, JE Ferrell Jr, JE Ferrell Jr, JE Gonzalez-Pastor, JE Lisman, JM Abraham, JM Anderson, JM Pedraza, JR Glynn Jr, JW Veening, K Lewis, KA Susanna, KP Lemon, KZ Abshire, L Cai, LF Greer III, LW Hamoen, LW Hamoen, M Acar, M Albano, M Albano, M Albano, M Cohn, M Cohn, M Lange, M Laurent, M Leisner, M Santillán, M Thattai, M Woude van der, MB Elowitz, MB Elowitz, MG Miller, MJ Hoek van, MR Barer, N Chantratita, N Friedman, N Rosenfeld, N Yildirim, N Yildirim, NC Shaner, NC Shaner, NE Kramer, NQ Balaban, P Viswanathan, PS Swain, R Amann, R Carballido-Lopez, R Thomas, R Thomas, RA Daniel, RE Zordan, RI Amann, RJ Bennett, RM Morgan-Kiss, RN Singh, RN Singh, RP Burchard, RP Haugland, RY Tsien, S Guiral, S Hooshangi, S Stibitz, SB Williams, SE Finkel, SR Biggar, SR Lockhart, SR Lockhart, SV Avery, T Hornbaek, T Nishino, T Tian, T Tolker-Nielsen, TF Meyer, TS Gardner, TT Hoa, V Sentchilo, V Sentchilo, WK Smits, WK Smits, WK Smits   +159 more
core   +3 more sources

A Type System for a Stochastic CLS [PDF]

, 2009
The Stochastic Calculus of Looping Sequences is suitable to describe the evolution of microbiological systems, taking into account the speed of the described activities.
Angelo Troina, Gabriel Ciobanu, Mariangiola Dezani-Ciancaglini, Paola Giannini   +3 more
core   +4 more sources

Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state. [PDF]

PLoS Computational Biology, 2018
Within an isogenic population, even in the same extracellular environment, individual cells can exhibit various phenotypic states. The exact role of stochastic gene-state switching regulating the transition among these phenotypic states in a single cell ...
Hao Ge, Pingping Wu, Hong Qian, Xiaoliang Sunney Xie   +3 more
doaj   +1 more source

Quantitative Characterization of Combinatorial Transcriptional Control of the Lactose Operon of E. coli [PDF]

Proc Natl Acad Sci 104(14): pp. 6043-6048 (2007), 2007
It is the goal of systems biology to understand the behavior of the whole in terms of the knowledge of the parts. This is hard to achieve in many cases due to the difficulty of characterizing the many constituents and their complex web of interactions involved in a biological system. The lac promoter of E.
arxiv   +1 more source