Results 61 to 70 of about 128,431 (240)

Phenotypic Variation and Bistable Switching in Bacteria [PDF]

, 2008
Microbial research generally focuses on clonal populations. However, bacterial cells with identical genotypes frequently display different phenotypes under identical conditions.
A Becskei, A Becskei, A Guerrero, A Johnson, A Khlebnikov, A Khlebnikov, A Khlebnikov, A Lipshtat, A Moter, A Novick, AE Merode van, AE Merode van, AE Tsong, B Muller-Hill, B Slutsky, BB Magee, BE Laue, BF Brehm-Stecher, BJ Haijema, C Hadden, C Wiuff, CM Hull, CM Hull, CM Southward, CY Lan, D Angeli, D Dubnau, D Dubnau, D Dubnau, D Kidane, D Sinderen van, D Sinderen van, DB Kearns, DC Dooley, DH Dean, DR Soll, E Korobkova, E Kussell, EH Rikkerink, EJ Stewart, EM Ozbudak, EM Ozbudak, ER Sumner, EW Nester, F Jacob, F Joux, F Ortega, F Russo-Marie, FH Cahn, FH Kasten, FJ Isaacs, G Huang, G Nebe-von-Caron, GM Suel, GM Suel, H Kobayashi, H Maamar, H Makinoshima, H Steinmoen, H Steinmoen, HB Fraser, HM Davey, I Golding, I Golding, I Hautefort, IR Henderson, J Casadesus, J Hahn, J Hahn, J Hasty, J Hasty, J Holtzendorff, J Kreth, J Monod, J Vidal-Mas, J Vives-Rego, J Zieg, JD Chung, JD Chung, JD Chung, JE Ferrell Jr, JE Ferrell Jr, JE Gonzalez-Pastor, JE Lisman, JM Abraham, JM Anderson, JM Pedraza, JR Glynn Jr, JW Veening, K Lewis, KA Susanna, KP Lemon, KZ Abshire, L Cai, LF Greer III, LW Hamoen, LW Hamoen, M Acar, M Albano, M Albano, M Albano, M Cohn, M Cohn, M Lange, M Laurent, M Leisner, M Santillán, M Thattai, M Woude van der, MB Elowitz, MB Elowitz, MG Miller, MJ Hoek van, MR Barer, N Chantratita, N Friedman, N Rosenfeld, N Yildirim, N Yildirim, NC Shaner, NC Shaner, NE Kramer, NQ Balaban, P Viswanathan, PS Swain, R Amann, R Carballido-Lopez, R Thomas, R Thomas, RA Daniel, RE Zordan, RI Amann, RJ Bennett, RM Morgan-Kiss, RN Singh, RN Singh, RP Burchard, RP Haugland, RY Tsien, S Guiral, S Hooshangi, S Stibitz, SB Williams, SE Finkel, SR Biggar, SR Lockhart, SR Lockhart, SV Avery, T Hornbaek, T Nishino, T Tian, T Tolker-Nielsen, TF Meyer, TS Gardner, TT Hoa, V Sentchilo, V Sentchilo, WK Smits, WK Smits, WK Smits   +159 more
core   +3 more sources

Accurate prediction of gene expression by integration of DNA sequence statistics with detailed modeling of transcription regulation [PDF]

, 2010
Gene regulation involves a hierarchy of events that extend from specific protein-DNA interactions to the combinatorial assembly of nucleoprotein complexes.
Alberts, Berg, Bussemaker, Bussemaker, Djordjevic, Hudson, Jacob, Jose M.G. Vilar, Liu, Liu, Markstein, Mossing, Müller, Müller-Hill, Oehler, Oehler, Roider, Saiz, Saiz, Saiz, Saiz, Saiz, Stormo, Tavazoie, Tronche, van Batenburg, van Nimwegen, Veprintsev, Vilar, Vilar, Wasserman, Zhao   +31 more
core   +3 more sources

DNA looping: the consequences and its control [PDF]

, 2006
The formation of DNA loops by proteins and protein complexes is ubiquitous to many fundamental cellular processes, including transcription, recombination, and replication.
Ackers, Adhya, Alberts, Becker, Bloomfield, Broach, Cloutier, de Lange, Dodd, Du, Dunn, Halford, Hanke, Hill, Irani, Jose MG Vilar, Knight, Leonor Saiz, Lewis, Li, Matthews, Moreau, Mossing, Muller, Müller-Hill, Oehler, Olson, Ptashne, Ptashne, Radman-Livaja, Revet, Richmond, Ringrose, Rippe, Saiz, Saiz, Schleif, Semsey, Stenger, Tolhuis, Vilar, Vilar, Villa, Yan, Yasmin, Zhang   +45 more
core   +1 more source

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR [PDF]

, 2008
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream
Belyaeva, Bourgerie, Caswell, Choy, David C. Grainger, Gallegos, Grainger, Grainger, Gralla, Hansma, Ishihama, Kachroo, Kahramanoglou, Kolb, Lee, Lodge, Martin, Meares, Michán, Miller, Mohamed Samir El-Robh, Panos Soultanas, Perrin, Plumbridge, Rojo, Roy, Schleif, Schleif, Semsey, Shivanthi Samarasinghe, Stephen J. W. Busby, Tobes, Virnik, Wade, Wade, Wang, Webster, Webster, Webster, Wenke Zhang, Williams, Zhang   +41 more
core   +4 more sources

A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell [PDF]

, 2010
By monitoring fluorescently labeled lactose permease with single-molecule sensitivity, we investigated the molecular mechanism of how an Escherichia coli cell with the lac operon switches from one phenotype to another.
Cai, Long, Choi, Paul Jongjoon, Frieda, Kirsten, Xie, Xiaoliang Sunney   +3 more
core   +5 more sources

Molecular Distributions in Gene Regulatory Dynamics [PDF]

, 2010
We show how one may analytically compute the stationary density of the distribution of molecular constituents in populations of cells in the presence of noise arising from either bursting transcription or translation, or noise in degradation rates ...
Acar, Arnold, Berg, Blake, Blake, Bobrowski, Cai, Chubb, Elowitz, Feistel, Fraser, Friedman, Gardiner, Gardner, Gillespie, Golding, Goodwin, Griffith, Griffith, Hawkins, Hierro, Horsthemke, Jacob, Kaern, Kepler, Lasota, Lipniacki, Lipshtat, Mackey, Mariani, Marta Tyran-Kamińska, Michael C. Mackey, Ochab-Marcinek, Ochab-Marcinek, Oppenheim, Othmer, Pichór, Polynikis, Raj, Raj, Raser, Romain Yvinec, Scott, Selgrade, Shahrezaei, Shahrezaei, Shahrezaei, Sigal, Smith, Song, Swain, Titular, Wilemski, Yildirim, Yu, Zacharioudakis   +55 more
core   +5 more sources

Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state. [PDF]

PLoS Computational Biology, 2018
Within an isogenic population, even in the same extracellular environment, individual cells can exhibit various phenotypic states. The exact role of stochastic gene-state switching regulating the transition among these phenotypic states in a single cell ...
Hao Ge, Pingping Wu, Hong Qian, Xiaoliang Sunney Xie   +3 more
doaj   +1 more source

Boolean Models of Bistable Biological Systems

, 2009
This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model.
A. Novick, C. Conradi, E. Aurell, F. Jacob, L. Mendoza, M. Cohn, M. Ptashne, M. Santillán, N. Friedman, N. Yildirim, P. Wong, R. Albert, R. de Boer, R. Edwards, R. Laubenbacher, S. A. Kauffman, T. Tian   +16 more
core   +1 more source

CadC-mediated activation of the cadBA promoter in Escherichia coli [PDF]

, 2005
The transcriptional activator CadC in Escherichia coli, a member of the ToxR-like proteins, activates transcription of the cadBA operon encoding the lysine decarboxylase CadA and the lysine-cadaverine antiporter CadB. cadBA is induced under conditions of
Jung, K., Kuper, C.
core   +1 more source

Structural Explanation for Allolactose (lac Operon Inducer) Synthesis by lacZ β-Galactosidase and the Evolutionary Relationship between Allolactose Synthesis and the lac Repressor

Journal of Biological Chemistry, 2013
Background: Synthesis of allolactose (lac operon inducer) from lactose requires a site for clasping glucose as an acceptor on β-galactosidase. Results: The structure of the glucose site was defined, and its evolutionary conservation was determined ...
R. Wheatley, S. Lo, L. J. Jancewicz, M. L. Dugdale, R. E. Huber   +4 more
semanticscholar   +1 more source