Results 91 to 100 of about 7,921 (224)

Response to anti-seizure medications in children carrying novel or previously reported HCN1 gene variants. [PDF]

Epilepsia Open
Abstract Objective Variants in the HCN1 gene cause a syndrome of childhood epilepsy and developmental disability with a broad phenotypic range. Many affected children manifest with early infantile epileptic encephalopathy (EIEE) and highly drug‐resistant epilepsy.
Khan MN, Poolos NP.
europepmc   +2 more sources

Safety of intravenous lacosamide in critically ill children.

, 2017
PURPOSE: Acute seizures are common in critically ill children. These patients would benefit from intravenous anti-seizure medications with few adverse effects.
Welsh, Sarah S, Abend, Nicholas S, Topjian, Alexis A, Lin, Nan   +3 more
core  

Lacosamide in patients with pharmacoresistant epilepsy

, 2012
Introduction: Lacosamide is a novel antiepileptic drug licensed in the US and Europe as adjunctive therapy for partial-onset seizures in adults. The efficacy, safety, tolerability and favorable pharmacokinetic profile in the adult population suggest that
Verrotti, Alberto, Olivieri, Cristina, Zulli, Enrico, Zaccara, Gaetano, Loiacono, Giulia   +4 more
core   +1 more source

Preliminary evidence of long‐term safety and effectiveness of anti‐CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Epilepsia Open, EarlyView.
Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort of adults with comorbid migraine and epilepsy treated with anti‐CGRP ...
Marina Romozzi, Andrea Burgalassi, Francesco Ceriello, Pietro Martino, Giuliano Sette, Francesca Pistoia, Fabio Placidi, Diego Centonze, Luca Pani, Jacopo Canonichesi, Catello Vollono, Paolo Calabresi, Maria Albanese, Luigi Francesco Iannone   +13 more
wiley   +1 more source

Safety, Tolerability, and Dose-Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis: Protocol for a Phase 1 Clinical Trial to Determine Safety and Identify Side Effects

JMIR Research Protocols
BackgroundChronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for pain control.
Evan L Fogel, Jeffrey J Easler, Ying Yuan, Dhiraj Yadav, Darwin L Conwell, Santhi Swaroop Vege, Samuel Y Han, Walter Park, Vanessa Patrick, Fletcher A White   +9 more
doaj   +1 more source

In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells

Journal of Experimental & Clinical Cancer Research, 2017
Background Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon.
Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio, Emilio Ciusani   +8 more
doaj   +1 more source

Total Synthesis of Lacosamide

, 2016
Total synthesis of anticonvulsant amino acid, lacosamide, is reported. The key step is stereospecific allyl cyanate-to-isocyanate rearrangement, which proceeds with chirality transfer.
Sebastian Stecko (1393120)
core   +1 more source

A case series of lacosamide as adjunctive therapy in refractory sleep-related hypermotor epilepsy (previously nocturnal frontal lobe epilepsy) [PDF]

, 2018
The aim of this study was to evaluate the efficacy and tolerability of open-label lacosamide in patients with refractory sleep-related hypermotor epilepsy.
Samarasekera, SR, Berkovic, SF, Scheffer, IE   +2 more
core   +1 more source

Reversal of refractory epilepsy in an adult with GAMT deficiency: A case report and comparative literature review

Epilepsia Open, EarlyView.
Abstract Objective Guanidinoacetate methyltransferase (GAMT) deficiency is a rare autosomal recessive creatine biosynthesis disorder. Reports specifically focusing on adult patients remain scarce. Methods We report a 52‐year‐old female (the oldest documented case of GAMT deficiency to date) presenting with severe intellectual disability, refractory ...
Wei‐Hung Sung, Hsi Chen, Che‐Wei Hsu, Meng‐Han Tsai   +3 more
wiley   +1 more source

Improved Synthesis and Impurity Identification of (R)‑Lacosamide

, 2019
An improved synthesis of Lacosamide 1 with high purity has been developed. Critical parameters of each step were identified as well as the impurities generated. Moreover, a creative method to improve chiral purity and stability of the key intermediate (R)
Feifei Hu (1909549), Feifei Hu, Jianguang Cai (307029), Anjiang Yang (6489476), Fuli Zhang (506665), Chuanmeng Zhao, Linghui Wang, Fuli Zhang, Chuanmeng Zhao (6489479), Tao Zhang (43681), Tao Zhang, Mengdi Chen (1560865), Anjiang Yang, Zhong Li, Jianguang Cai, Mengdi Chen, Zhong Li (324520), Linghui Wang (4760172)   +17 more
core   +1 more source