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Beyond seizure control: Non–seizure‐related outcomes in focal‐onset epilepsy treated with adjunctive cenobamate. Third interim results from the BLESS study
Epilepsia, EarlyView.Abstract Objective
Cenobamate is approved for treatment of focal seizures in adults, but evidence on non‐seizure outcomes remains limited. This interim statistical analysis of the cenoBamate in aduLts with focal‐onsEt SeizureS (BLESS) study evaluated patient‐ and clinician‐reported outcomes for up to 52 weeks of cenobamate treatment.Simona Lattanzi, Giuseppe d'Orsi, Maria Teresa Di Claudio, Alfredo D'Aniello, Stefano Luca Sensi, Fedele Dono, Mariangela Panebianco, Luigi Sicurella, Alessandra Di Liberto, Andrea Novara, Carlo Di Bonaventura, Paolo Bonanni, Claudio Liguori, Federica Ranzato, Antonio Gambardella, Francesca Bisulli, Patrizia Pulitano, Giada Pauletto, Elena Tartara, Giampaolo Vatti, Giovanni Assenza, Alfonso Giordano, Anna Elisabetta Vaudano, Gionathan Mazza, Angela La Neve, Pietro Pignatta, Simone Beretta, Marianna Pezzella, Michela Cecconi, Chiara Pizzanelli, Vincenzo Andreone, Catello Vollono, Monica Puligheddu, Massimo Gangitano, Daniela Audenino, Nicoletta Foschi, Elisa Fallica, Giovanni Boero, David Stokelj, Maria Pia Pasolini, Luciana Tramacere, Gionata Strigaro, Edoardo Ferlazzo, Tiziano Zanoni, Pietro Penza, Maurizio Elia, Stefano Quadri, Giovanni De Maria, Monica Santo Sabato, Loretta Giuliano, Rosita Galli, Angelo Labate, Filippo Dainese, Giovanni Falcicchio, Roberto De Simone, Michela Procaccini, Valentina Villano, Gabriele Camattari, Daniele Andreis, Lucia Simoni, Giancarlo Di Gennaro, on behalf of the BLESS Study Group, Cecilia Catania, Alessandra Morano, Biagio Orlando, Maria Sole Borioni, Fabrizio Giaculli, Luca Pasquale Giordano, Francesca Pia Mazzeo, Marco Belluzzo, Anna Carmen Nilo, Alessia Peretti, Diana Polo, Anna Bolzan, Giulia Lippa, Marianna Nesta, Lorenzo Ricci, Felice Altieri, Alberto Danieli, Elisa Osanni, Francesco Fortunato, Giuseppe Magro, Laura Marino, Ilaria Sammarra, Francesca Felicia Operto, Carlo Andrea Galimberti, Domenico Lomonaco, Alessia Campomori, Devis Collura, Emanuela Viglietta, Lorenzo Muccioli, Martina Soldà, Veronica Viola, Nicolò Locatelli, Francesca Simonetti, Barbara Mostacci, Roberta Coa, Antonio Valentino Saporito, Vincenzo Belcastro, Valeria Badioni, Maria Grazia Pascarella, Luciano Pellegrino, Angelina Laganà, Rosario Beccore, Orazio Pardeo, Francesco Luppino, Serena Raineri, Stefano Meletti, Niccolò Biagioli, Matteo Pugnaghi, Giada Giovannini, Simona Scolastico, Margherita Burani, Lisa Taruffi, Cecilia Zivelonghi, Umberto Aguglia, Vittoria Cianci, Roberta Cutellè, Angelo Pascarella, Laura Buttarelli, Roberto Matrullo, Davide Toraldo, Chiara Di Blasi, Valeria Sarro, Antonio Volzone, Massimo Di Giovanni, Stefano Avventura, Maria Francesca Tepedino, Andrea Latino, Antonella Morea, Nicola Pilolli, Giuseppe Pontrelli, Luigi Vetri, Giulia Fatati, Sabina Bartalini, Giulia Maccanti, Giulia Beneduce, Damiano Bruno, Giacomo Evangelista, Michelangelo Dasara, Clarissa Corniello, Stefano Consoli, Davide Liviello, Paolo Quintieri, Francesco Habetswallner, Rosaria Renna, Vincenzo Loreto, Edward Cesnik, Carla Marcialis, Martina Romozzi, Costanza Sottani, Matteo Antonucci, Alessio D'Elia, Laura Carmillo, Lavinia Vassallo, Eloise Lo Mauro, Salvatore Maria Lima, Federica Cerasa, Barbara Chiocchetti, Martina Calistri, Andrea Scalvini, Elisabetta Del Zotto, Alice Figura, Giovanni Messina, Marta Maria Tentorio, Paolo Costa, Chiara Silvestri, Elisabetta Rolla, Leandro Purin, Luca Colombo, Morgan Trevisan, Gabriele Mainini, Romano Giovanni Orofino, Matteo Impellizzeri, Maria Cristina Servalli, Paolo Paone, Sara Mazzoleni, Martina Fanella, Teresa Francavilla, Daniele Graziani, Pamela Rosettani, Sara Zagaglia, Luciana Mollo, Azzurra Biagiotti, Alessandro Alesi, Maria Teresa Di Claudio, Pierangela Riani, Fabio Iannaccone, Claudia Scarpitta, Maria Proietto, Angelo Battiato, Salvatore Dominici, Martina Guadagni, Daniela Marino, Rossella Papetti, Marzia Carlini, Lucia Farotti, Marinella Tomaselli, Stefania Pavan, Matteo Cegalin, Elisa Montalenti, Giovanni Battista Rossi, Edoardo Della Sala, Claudio Gojani, Camilla Bertolini, Edoardo Pronello, Francesca Lozza +206 morewiley +1 more sourceConcise Synthesis of Lacosamide with High Chiral Purity
, 2019 An efficient synthesis
process of an antiepileptic drug, lacosamide,
with high chiral purity has been developed. A series of acids were
screened to form salts with the key intermediate 4, and
phosphoric acid, an inexpensive and achiral reagent, turned ...Jiang-Tao Yang (1493017), Sheng-Hua Gao (6575189), Meng-Di Chen, Jiang-Tao Yang, An-Jiang Yang, Fu-Li Zhang, Chun-Jie Zhao (6575192), An-Jiang Yang (4379827), Fu-Li Zhang (2855801), Chun-Jie Zhao, Meng-Di Chen (6575183), Zhong Li, Fei-Fei Hu (6575186), Zhong Li (324520), Fei-Fei Hu, Sheng-Hua Gao +15 morecore +1 more sourceStatin use and risk of remote seizure after first new onset status epilepticus
Epilepsia, EarlyView.Abstract Objective
Preclinical evidence supports the role of statins as antiepileptogenic agents. In this study, we investigated the risk of remote unprovoked seizures (RS) according to the use of statin therapy in a cohort of first‐ever status epilepticus (SE) survivors. Methods
Retrospective analysis was made of adult patients (age ≥ 14 years) with a Niccolò Orlandi, Giada Giovannini, Lisa Taruffi, Margherita Burani, Jefe Laureine Ngnintedem Dontsop, Mara Malerba, Simona Scolastico, Laura Madrassi, Leonardo Affronte, Matteo Pugnaghi, Anna Elisabetta Vaudano, Simona Lattanzi, Stefano Meletti +12 morewiley +1 more sourceThe investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
, 2007 We hypothesized that lacosamide modulates voltage-gated sodium channels (VGSCs) at clinical concentrations (32-100 μM). Lacosamide reduced spiking evoked in cultured rat cortical neurons by 30-s depolarizing ramps but not by 1-s ramps.G. Lees, Lees, G., Heers, C., T. Stohr, Stohr, T., C. Heers, A. C. Errington, Errington, Adam +7 morecore +1 more sourceInherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.Itay Tokatly Latzer, Phillip L. Pearlwiley +1 more sourceData from: Efficacy and tolerability of adjunctive lacosamide in pediatric patients with focal seizures [PDF]
, 2019 Objective: To evaluate efficacy and tolerability of adjunctive lacosamide in children and adolescents with uncontrolled focal (partial-onset) seizures.
Methods: Double-blind trial (SP0969; NCT01921205) of patients (≥4 to Scheffer, Ingrid E., Bozorg, Ali, Flamini, J. Robert, Yuen, Nancy, Borghs, Simon, Daniels, Tony, Dimova, Svetlana, SP0969 Study Group, Dimova, S, Bozorg, A, Steinborn, Barbara, Flamini, J Robert, Carney, Hannah C., Steinborn, B, Flamini, JR, Farkas, Viktor, Scheffer, Ingrid E, Martin, Paul, Yuen, N, Zhang, Y, Daniels, T, Carney, HC, Farkas, V, Borghs, S, Scheffer, IE, Zhang, Ying, Martin, P, Carney, Hannah C +27 morecore +1 more source
