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Lacosamide: An investigational drug for adjunctive treatment of partial-onset seizures

, 2008
Lacosamide, (R)-2-acetamido-N-benzyl-3-meth- oxypropionamide, is a new chemical entity specifically synthesized as an anticonvulsive drug candidate, which appears to have a novel dual mode of action.
Ben-Menachem, Elinor,, Ben-Menachem, E.
core +1 more source

Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease

, 2023
Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that primarily affects the motor system. Although there are several treatments available to alleviate PD symptoms, there is currently no cure for the disease ...
Gurkan Yigitturk +9 more
core +1 more source

Oligogenic inheritance in epilepsy: A systematic exome‐wide analysis

Epilepsia, EarlyView.
Abstract Objective Genetic factors contribute to the majority of epilepsies, but the exact genetic cause remains unknown in most patients. Incomplete penetrance and variable expressivity are frequent, and recent studies showed a burden of deleterious variants in epilepsy genes, suggesting a role for oligogenic inheritance.
Sarah Duerinckx +192 more
wiley +1 more source

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku +4 more
wiley +1 more source

Lacosamide in children with drug-resistant epilepsy

, 2019
AIM: To assess the effectiveness and tolerability of lacosamide in paediatric clinical practice. METHODS: A search of our hospital's pharmacy database yielded all children
Rüegger, AD, Harvey, AS, Freeman, JL
core +1 more source

Functional/dissociative seizures as a manifestation of forced normalization in eyelid myoclonia with absence epilepsy

Epileptic Disorders, EarlyView.
Fernando Vasquez‐Lopez +16 more
wiley +1 more source

Monthly or menstrual? A scoping review of catamenial epilepsy and non‐menstrual seizure rhythms

Epilepsia, EarlyView.
Abstract Objective Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual‐related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about‐monthly cycles, present in both men and women, further confound the ...
Victoria Wong +4 more
wiley +1 more source

Real‐world evaluation of capillary microsampling for drug monitoring of anti‐seizure medications

Epilepsia, EarlyView.
Abstract Objective Capillary microsampling offers a minimally invasive alternative to venipuncture for therapeutic drug monitoring (TDM) of anti‐seizure medications (ASMs). We evaluated the feasibility and reliability of volumetric absorptive microsampling (VAMS) and quantitative dried blood spot (qDBS) devices for ambulatory self‐collection and at ...
Chiara Cancellerini +8 more
wiley +1 more source

Intraoperative electrocorticography guiding surgical resection in epilepsia partialis continua secondary to cardiac myxoma embolism: A clinical vignette

Epileptic Disorders, EarlyView.
Olalla Urdanibia‐Centelles +7 more
wiley +1 more source

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

Epilepsia, EarlyView.
Long‐term efficacy and safety of adjunctive cenobamate in a multinational Asian population. Open‐label extension (OLE) efficacy population included all patients who had taken ≥1 dose of study drug and had any seizure data during the OLE maintenance phase.
Sang Kun Lee +20 more
wiley +1 more source

epilepsy
neurosciences
biological psychiatry

neuropsychiatry
arrhythmia
antiepileptic drugs