Results 51 to 60 of about 7,921 (224)

Stability-indicating liquid chromatographic method for quantification of new anti-epileptic drug lacosamide in bulk and pharmaceutical formulation [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2012
An isocratic stability indicating reversed-phase liquid chromatographic determination was developed for the quantitative determination of lacosamide in the pharmaceutical dosage form.
Chhalotiya Usmangani K., Bhatt Kashyap K., Shah Dimal A., Baldania Sunil L., Patel Jigar R.   +4 more
doaj   +1 more source

Genomic and clinical predictors of lacosamide response in refractory epilepsies

Epilepsia Open, 2019
Objective Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real‐world clinical setting.
Sinéad B. Heavin, Mark McCormack, Stefan Wolking, Lisa Slattery, Nicole Walley, Andreja Avbersek, Jan Novy, Saurabh R. Sinha, Rod Radtke, Colin Doherty, Pauls Auce, John Craig, Michael R. Johnson, Bobby P. C. Koeleman, Roland Krause, Wolfram S. Kunz, Anthony G. Marson, Terence J. O'Brien, Josemir W. Sander, Graeme J. Sills, Hreinn Stefansson, Pasquale Striano, Federico Zara, EPIGEN Consortium, EpiPGX Consortium, Chantal Depondt, Sanjay Sisodiya, David Goldstein, Holger Lerche, Gianpiero L. Cavalleri, Norman Delanty   +30 more
doaj   +1 more source

Profiling the protein interactions of the novel anticonvulsant (R)-lacosamide [PDF]

, 2010
The full spectrum of proteins that interact with the anticonvulsant (R)-lacosamide remain unknown despite the compound's approval in both Europe and the United States for treatment of partial seizures.
Cotten, Steven Wesley
core   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Lacosamide dosing in patients receiving continuous renal replacement therapy

Journal of Intensive Care, 2023
Background Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosamide dosing regimens in critically ill patients receiving continuous renal replacement therapy (CRRT) via Monte Carlo ...
Weerachai Chaijamorn, Sathian Phunpon, Thanompong Sathienluckana, Taniya Charoensareerat, Sutthiporn Pattharachayakul, Dhakrit Rungkitwattanakul, Nattachai Srisawat   +6 more
doaj   +1 more source

Cardiac Electrophysiological Effects of the Sodium Channel-Blocking Antiepileptic Drugs Lamotrigine and Lacosamide

Pharmaceuticals
Background: The two antiepileptic drugs lacosamide and lamotrigine exert their antiepileptic effect by inhibiting sodium channels. Lacosamide enhances the inactivation of sodium channels, while lamotrigine inhibits the activation of the channel ...
Julian Wolfes, Philipp Achenbach, Felix K. Wegner, Benjamin Rath, Lars Eckardt, Gerrit Frommeyer, Christian Ellermann   +6 more
doaj   +1 more source

Long‐term safety and tolerability of lacosamide monotherapy in patients with epilepsy: Results from a multicenter, open‐label trial

Epilepsia Open, 2021
The primary objective of this trial (SP1042; NCT02582866) was to assess long‐term safety and tolerability of lacosamide monotherapy (200‐600 mg/day) in adults with focal (partial‐onset) seizures or generalized tonic‐clonic seizures (without clear focal ...
Elinor Ben‐Menachem, Jacqueline Dominguez, József Szász, Cynthia Beller, Charles Howerton, Lori Jensen, Carrie McClung, Robert Roebling, Björn Steiniger‐Brach   +8 more
doaj   +1 more source

Risk of hostility and aggression with perampanel monotherapy versus combination therapy in pediatric epilepsy: A Japanese post‐marketing database study using a nested case–control design

Epileptic Disorders, EarlyView.
Abstract Objective To compare the incidence of hostility‐ and aggression‐related adverse events in children with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS), receiving perampanel as monotherapy or in combination with other antiseizure medications (ASMs).
Yukitoshi Takahashi, Masato Takeuchi, Akiko Yoshimura, Kasumi Daidoji, Kazuhiro Matsutani, Mika Ishii   +5 more
wiley   +1 more source

Lacosamide-Induced Recurrent Ventricular Tachycardia in the Acute Care Setting

, 2017
Lacosamide is a new-generation antiepileptic drug (AED) most commonly used adjunctively in the setting of partial-onset seizures refractory to traditional therapy. We describe the first case report, to our knowledge, of a patient who developed recurrent,
Matthew P. Lillyblad, Adrian K. Almquist, Theodore J. Berei   +2 more
core   +1 more source

Voltage-gated calcium channels are not affected by the novel anti-epileptic drug lacosamide [PDF]

, 2011
The novel anti-epileptic drug lacosamide targets two proteins — voltage-gated sodium channels and collapsin response mediator protein 2 (CRMP-2) — suggesting dual modes of action for lacosamide.
Khanna, Rajesh, Rajesh Khanna, Yuying Wang, Wang, Yuying   +3 more
core   +1 more source