Results 81 to 90 of about 7,921 (224)

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source

Genomic and clinical predictors of lacosamide response in refractory epilepsies

, 2021
Objective: Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting.Methods: We tested the association of clinical predictors with ...
Jan Novy (10578523), Andreja Avbersek (7947860), Saurabh R Sinha (10578528), David Goldstein (57135), EpiPGX Consortium (10490732), Michael R Johnson (7947884), Sanjay Sisodiya (2735497), Sinead B Heavin (10578520), Josemir W Sander (6789449), Pasquale Striano (4479343), Mark McCormack (7947842), Nicole Walley (5676983), Holger Lerche (455372), Norman Delanty (7895990), Graeme J Sills (7947872), Gianpiero Cavalleri (7895525), Wolfram S Kunz (7947893), Pauls Auce (7947878), Roland Krause (4351), Chantal Depondt (7947869), Rod Radtke (10578529), Colin Doherty (8713279), Federico Zara (176248), Terence J O'Brien (7947908), EPIGEN Consortium (10659843), Stefan Wolking (5687657), Hreinn Stefansson (160840), Lisa Slattery (7948745), Bobby P C Koeleman (7947887), John Craig (10534181), Anthony G Marson (7947875)   +30 more
core   +1 more source

Effects of Levetiracetam and Lacosamide on survival and seizure control in IDH-wild type glioblastoma during temozolomide plus radiation adjuvant therapy

Brain and Spine
Introduction: There are no clear indications for the best choice of anti-seizure medications to control brain tumor related epilepsy. In vitro studies have shown an antitumoral effect of Levetiracetam and Lacosamide on glioblastoma IDH-wild type ...
Andrea Bianconi, Emanuele Koumantakis, Andrea Gatto, Pietro Zeppa, Ayoub Saaid, Elsa Nico, Francesco Bruno, Alessia Pellerino, Francesca Rizzo, Carola Vera Junemann, Antonio Melcarne, Diego Garbossa, Paola Dalmasso, Fabio Cofano   +13 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Lacosamide for the Treatment of Refractory Status Epilepticus

, 2011
Objective: To evaluate current evidence for the use of lacosamide in the treatment of refractory status epilepticus. Data Sources: Literature was accessed via PubMed (through July 2011) using the terms lacosamide and status epilepticus.
Andrew J Franck, Erica M Fernandez
core   +1 more source

Efficacy and tolerability of adjunctive lacosamide in patients aged <4 years with focal seizures

Annals of Clinical and Translational Neurology
Objective Primary objective was to evaluate efficacy of lacosamide administered concomitantly with 1–3 antiseizure medications in young children with uncontrolled focal (partial‐onset) seizures.
Iryna Makedonska, Yu‐Tze Ng, Cynthia Beller, Ali Bozorg, János Csikós, Carrie McClung, Holger Moeltgen, Mark Kristof Farkas, the SP0967 Study Group   +8 more
doaj   +1 more source

Natural language processing‐based emotion and usage analysis of an AI‐powered chatbot for epilepsy support

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence (AI)‐powered chatbots are increasingly used for patient education and mental health support, yet their effectiveness in epilepsy care remains underexplored. This study examines text‐based interactions between users and EpiloBot, an epilepsy‐focused chatbot, to understand conversational patterns and emotional ...
Keiichi Watanuki, Ryoya Oba, Naoki Nozawa, Tomoki Ishihara, Koko Oga, Takayuki Iwayama, Takafumi Shiganami, Sayaka Kobayashi, Hironori Kuga, Haruo Yoshimasu, Izumi Kuramochi   +10 more
wiley   +1 more source

DECREASE study: A European pool-analysis of patients with significant reductions in concomitant antiseizure medications in cenobamate Early Access Programs. [PDF]

Epilepsia Open
Abstract Objective To evaluate the effectiveness and tolerability of cenobamate in patients with a significant reduction in concomitant antiseizure medication (ASM) in European cenobamate Early Access Programs (EAPs). Method Anonymized patient data from real‐world studies/registries associated with European cenobamate EAPs were pooled.
Villanueva V, Lattanzi S, Peña-Ceballos J, Thomas RH, Rodríguez-Uranga J, Jordán Z, Steinhoff BJ, von Wrede R, Delanty N, Moloney PB, Roberti R, Boero G, Canafoglia L, Specchio N, Gambardella A, Ferlazzo E, Operto FF, Tartara E, Garratt H, Fabó D, Gómez-Ibáñez A, Torres-Gaona G, Novitskaya Y, Surges R, Hampel K, Schulze-Bonhage A.   +25 more
europepmc   +2 more sources

Fenfluramine in Rett syndrome: A multidimensional clinical study

Epilepsia Open, EarlyView.
Abstract Objective Rett syndrome (RTT) is a severe neurodevelopmental disorder frequently associated with drug‐resistant epilepsy, autonomic dysfunction, respiratory abnormalities, sleep disturbances, and behavioral impairment. Fenfluramine has shown efficacy in developmental and epileptic encephalopathies and may provide broader therapeutic benefits ...
Elena Gonzalez‐Alguacil, Nuria Lamagrande Casanova, Manuel Luján Bonete, David Mansilla Lozano, Juan José García Peñas, María Ballará Petitbó, Rocío Trincado Lamuño, Verónica Cantarín‐Extremera, Raquel Díaz Conejo, César Rodríguez Sánchez, Adrián García Ron, Víctor Soto Insuga   +11 more
wiley   +1 more source

Outcomes of patients with post‐stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence

Epilepsia Open, EarlyView.
Abstract Objective Post‐stroke epilepsy (PSE) affects ≈10% of patients with stroke and is associated with adverse health and economic outcomes. We aimed to review published literature on health and economic outcomes for patients with PSE, with a specific focus on quality of life, hospital readmissions, healthcare costs, seizure recurrence, and ...
Nega Dagnew Baye, Emma Foster, Muideen T. Olaiya, Nigel C. Jones, Monique F. Kilkenny, Lachlan L. Dalli   +5 more
wiley   +1 more source