Results 101 to 110 of about 7,921 (224)

A real‐world analysis of AI chatbot performance for medicines information enquiries

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background The provision of medicines information (MI) services requires interpretation and clinical judgement of complex scenarios by pharmacists. To date, few studies have assessed the performance of artificial intelligence (AI) chatbots to assist pharmacists providing MI advice.
Duncan Yorkston, Tracey Borrie, Paul Chin   +2 more
wiley   +1 more source

Saliva-based lacosamide monitoring paves the way toward personalized epilepsy pharmacotherapy

Scientific Reports
Saliva, known for better patient compliance and simpler collection, is ideal for monitoring antiseizure medication (ASM) levels. This study aimed to validate saliva for measuring lacosamide, develop a pharmacokinetic (PK) model, and determine the optimal
Yoonhyuk Jang, Seon-Jae Ahn, Soyoung Lee, Yongmoo Kim, Han Sang Lee, Yoon-Kyung Lee, Yong Woo Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Joo-Youn Cho, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, In-Jin Jang, Sang Kun Lee   +16 more
doaj   +1 more source

A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV 1.2.Mena Abdelsayed1, Stanislav Sokolov1, Peter C. Ruben*1 - These authors contributed equally to this work* - Corresponding author

Frontiers in Pharmacology, 2013
Epilepsy is a disorder characterized by seizures and convulsions. The basis of epilepsy is an increase in neuronal excitability that, in some cases, may be caused by functional defects in neuronal voltage gated sodium channels (NaVs).
Mena eAbdelsayed, Stanislav eSokolov, Peter eRuben   +2 more
doaj   +1 more source

Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy [PDF]

, 2013
We report a case of sustained ventricular tachycardia following the initiation of lacosamide as adjunctive epilepsy treatment. A 49-year-old male with intractable frontal lobe seizures experienced severe ventricular tachycardia following the addition of ...
Desso, Tamara E, Lee, Lance, DeGiorgio, Andrew C, DeGiorgio, Christopher M   +3 more
core   +1 more source

DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF LACOSAMIDE IN BULK AND TABLET DOSAGE FORM [PDF]

, 2013
: To develop a simple, precise, accurate and reproducible spectrophotometry method for estimation of Lacosamide by employing first order derivative method and validate it as per ICH guidelines.
PARMAR, SHRADDHA J., CHAUDHARI, RAJESHRI D., CHOKSI, VISHRUTI H., PATEL, BHAVNA A., DIVAN, TANVI   +4 more
core   +1 more source

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Case Report: Lacosamide unmasking SCN5A-associated Brugada syndrome in a young female with epilepsy

Frontiers in Cardiovascular Medicine
BackgroundLacosamide is frequently used as a mono- or adjunctive therapy for the treatment of adults with epilepsy. Although lacosamide is known to act on both neuronal and cardiac sodium channels, potentially leading to cardiac arrhythmias, including ...
Ying-Chi Shen, Jen-Chueh Wu, Ting-Tse Lin, Kai-Chung Chang, Jen-Jen Su, Jyh-Ming Jimmy Juang   +5 more
doaj   +1 more source

Cardiac adverse events associated with lacosamide: a disproportionality analysis of the FAERS database

Scientific Reports
Lacosamide was the first approved third-generation antiepileptic drug. However, real-world data regarding its adverse cardiac reactions in large samples still need to be completed.
Chengcheng Yang, Wanqi Zhao, Huihui Chen, Yinhui Yao, Jingmin Zhang   +4 more
doaj   +1 more source

Lacosamide in patients with epilepsy of cerebrovascular etiology

, 2020
Objectives: To assess tolerability and efficacy of lacosamide in adults with cerebrovascular epilepsy etiology (CVEE). Materials and methods: Exploratory post hoc analyses of a double‐blind, initial monotherapy trial of lacosamide vs carbamazepine ...
Rosenow, Felix, Bozorg, Ali, Brandt, Christian, Dimova, Svetlana, Ferrò, Bruno, Kälviäinen, Reetta, Zhang, Ying, Holmes, Gregory L., Steiniger‐Brach, Björn   +8 more
core   +1 more source

A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8

Brain Pathology, EarlyView.
We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren, Carola Hedberg‐Oldfors, Kittichate Visuttijai, Sara Nordström, Hans Goebel, Anders Oldfors   +5 more
wiley   +1 more source