Results 51 to 60 of about 74,505 (292)
Cell Reports, 2019 Summary: Whereas the primary actions of β-lactams are well characterized, their downstream effects are less well understood. Although their targets are extracellular, β-lactams stimulate respiration in Escherichia coli leading to increased intracellular ...
Loïc Léger +5 more
doaj +1 more source
Skeletal metalation of lactams through a carbonyl-to-nickel-exchange logic
Nature Communications, 2023 Classical metalation reactions such as the metal-halogen exchange have had a transformative impact on organic synthesis owing to their broad applicability in building carbon-carbon bonds from carbon-halogen bonds.
Hongyu Zhong +7 more
doaj +1 more source
Advanced Science, EarlyView.High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld +5 more
wiley +1 more source
Electron Donor–Acceptor Complex Catalysis in Synthetic Chemistry
Angewandte Chemie, EarlyView.Electron donor–acceptor (EDA) complexes are moving beyond stoichiometric photoactivation toward catalytic platforms for radical generation. Productive EDA catalysis requires coordinated donor–acceptor association, charge‐transfer excitation, radical reactivity, and vcatalyst turnover.
Tristan von Münchow +3 more
wiley +2 more sources
Identification of the Extracytoplasmic Function σ Factor σP Regulon in Bacillus thuringiensis
mSphere, 2022 Bacillus thuringiensis and other members of the Bacillus cereus family are resistant to many β-lactams. Resistance is dependent upon the extracytoplasmic function sigma factor σP.
Theresa D. Ho +4 more
doaj +1 more source
Bifunctional Asymmetric Catalysis: A Tandem Nucleophile/Lewis Acid Promoted Synthesis of β-Lactams
, 2016 We describe a superior procedure for the catalytic, asymmetric synthesis of β-lactams using a bifunctional catalyst system consisting of a chiral nucleophile and an achiral Lewis ...
Ahmed M. Hafez (2714233) +5 more
core +1 more source
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids
Angewandte Chemie, EarlyView.Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi +3 more
wiley +2 more sources
Enantioselective Synthesis of Alkaloids from Phenylglycinol-Derived Lactams
Natural Product Communications, 2011 This review is focused on recent synthetic achievements and ongoing work in our laboratory using phenylglycinol-derived oxazolopiperidone lactams as starting materials for the enantioselective synthesis of piperidine-containing alkaloids: madangamines, 2,
Mercedes Amat +4 more
doaj +1 more source
New Microbes and New Infections, 2019 We report a case of hospital-acquired pneumonia that to our knowledge is the first description in Egypt of the emergence of vancomycin (VA)-resistant Staphylococcus aureus due to the concomitant use of β-lactams.
A.E. Taha +3 more
doaj +1 more source