Results 31 to 40 of about 74,505 (292)
Chemistry of Bridged Lactams: Recent Developments
Molecules, 2019 Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765).
Roman Szostak, Michal Szostak
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2013 The cis- and trans-stereoselective radical additions to α-methylene-γ-alkyl- γ-lactams were investigated and the scope and limitation of the reaction were also revealed.
Tomoko Yajima +2 more
doaj +1 more source
Synthesis and Antimicrobial Activity of Some New Sugar-Based Monocyclic β-Lactams
Molecules, 2004 The syntheses of some new sugar-based monocyclic β-lactams possessing several other functionalities in addition to the carbohydrate moiety are described.
A. Taslimi +2 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Conversion of Glucuronic Acid Glycosides to Novel Bicyclic β-Lactams
, 2016 Methodology for the conversion of glucuronic acid glycosides to novel bicyclic β-lactams is reported. Using this strategy, we prepared two novel templates suitable for use in combinatorial chemistry strategies for the construction of a number of ...
Timothy B. Durham (1698085) +1 more
core +2 more sources
mBio, 2020 Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM ...
Tae Hwan Kim +19 more
doaj +1 more source
Photo‐Switchable Molecular Module Programming PET Biodegradation in Aquatic Environments
Advanced Functional Materials, EarlyView.We address the plastic durability paradox by integrating an itaconic acid–derived pyrrolidone module into polymer backbones. Sunlight in water triggers Norrish Type I ring‐opening and hydrophilization, enabling rapid biodegradation into nontoxic minerals.
Mohammad Asif Ali +16 more
wiley +1 more source
Synthesis of Novel N-Sulfonyl Monocyclic β-Lactams as Potential Antibacterial Agents
Molecules, 2006 New cis monocyclic β-lactams were synthesized by [2+2] Staudinger cycloaddition reactions of the imine (3,4-dimethoxybenzylidene)-(4-methoxyphenyl)- amine and ketenes derived from different acyl chlorides and Et3N.
Maaroof Zarei, Aliasghar Jarrahpour
doaj +1 more source
Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions
Advanced Science, EarlyView.Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han +11 more
wiley +1 more source