Results 11 to 20 of about 52,808 (261)
.GAMMA.-Lactam analogues of .BETA.-lactam antibiotics.
The Journal of Antibiotics, 1991 In vitro interactions between aztreonam (AZT) and 8 other antibiotics were studied using the agar dilution checkerboard technique against 88 clinical isolates of Escherichia coli, Proteus vulgaris, Serratia marcescens and Pseudomonas aeruginosa. Combinations of AZT with 8 other antibiotics were generally additive or indifferent.
J E, Baldwin, G P, Lynch, J, Pitlik
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Fast Solvent-free Alkylation of Amides and Lactams under Microwave Irradiation
Molecules, 1999 N-Substituted amides and lactams are rapidly N-alkylated under solvent-free phase-transfer catalytic conditions using microwaves.
Dariusz Bogdal
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Fungal Lactamases: Their Occurrence and Function
Frontiers in Microbiology, 2017 Fungi are absorptive feeders and thus must colonize and ramify through their substrate to survive. In so doing they are in competition, particularly in the soil, with myriad microbes.
Minglu Gao +3 more
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Arkivoc, 2022 Steroidal lactams are also a class of steroid derivatives that were synthesized and modified to increase the biological activity of steroids. Their synthesis is a stimulating challenge to the scientist, often claiming the development of new and generally useful reactions.
Ibrahim-Ouali, Malika, Dumur, Frédéric
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Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position
Frontiers in Chemistry, 2019 Mono- and disubstituted 4-CF3 β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.
Monika Skibińska +8 more
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Nature Communications, 2022 Six-membered chiral lactams are common structural motifs of pharmaceuticals. Here, the authors describe a nickel-catalyzed reductive carbamoylation of alkenes to form enantioenriched six-membered lactams.
Chenhuan Zhang +4 more
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F1000Research, 2021 Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs.
Erika Rodríguez Cavallo +3 more
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p-Nitrophenyl carbonate promoted ring-opening reactions of DBU and DBN affording lactam carbamates
Beilstein Journal of Organic Chemistry, 2016 The amidine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and DBN (1,5-diazabicyclo[4.3.0]non-5-ene) display nucleophilic behaviour towards highly electrophilic p-nitrophenyl carbonate derivatives with ring opening of the bicyclic ring to form ...
Madhuri Vangala, Ganesh P Shinde
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The future of the β-lactams [PDF]
Current Opinion in Microbiology, 2010 In the 80 years since their discovery the β-lactam antibiotics have progressed through structural generations, each in response to the progressive evolution of bacterial resistance mechanisms. The generational progression was driven by the ingenious, but largely empirical, manipulation of structure by medicinal chemists.
Llarrull, Leticia Irene +3 more
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Frontiers in Cellular and Infection Microbiology, 2023 With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu +4 more
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