Results 11 to 20 of about 68,227 (310)

A highly stereoselective oxidation and an easy one pot elimination methodology for 3-allyl-3-phenylthio-β-lactams

, 2021
A novel, facile, highly efficient and stereoselective protocol for the synthesis of cis-3-allyl-3-phenylsulfinyl-β-lactams and 3-allylidene-β-lactams from cis-3-allyl-3-phenylthio-β-lactams using Selectfluor both as an oxidizing agent and as an ...
Suvidha Pandey (11835468), Reshma Nagpal (6203189), Aarti Thakur (11835471), Shamsher S. Bari (3832459), Renu Thapar (6203192)   +4 more
core   +1 more source

Biologically Active 1-Arylpiperazines. Synthesis of New N-(4-Aryl-1-piperazinyl)alkyl Derivatives of Quinazolidin-4(3H)-one, 2,3-Dihydrophthalazine-1,4-dione and 1,2-Dihydropyridazine-3,6-dione as Potential Serotonin Receptor Ligands

Molecules, 2001
The synthesis of a series of new n-propyl and n-butyl chain containing 1-arylpiperazine derivatives of quinazolidin-4(3H)-one (7) 2-phenyl-2,3-dihydrophthalazine-1,4-dione (8) and 1-phenyl-1,2-dihydropyridazine-3,6-dione (9) as potential serotonin ...
Sijka Charakchieva-Minol, Andrzej J. Bojarski, Maria J. Mokrosz, Teresa Kowalska, Piotr Kowalski   +4 more
doaj   +1 more source

The future of the β-lactams [PDF]

Current Opinion in Microbiology, 2010
In the 80 years since their discovery the β-lactam antibiotics have progressed through structural generations, each in response to the progressive evolution of bacterial resistance mechanisms. The generational progression was driven by the ingenious, but largely empirical, manipulation of structure by medicinal chemists.
Llarrull, Leticia Irene, Testero, Sebastian Andres, Fisher, Jed F., Mobashery, Shahriar   +3 more
openaire   +3 more sources

Synthesis of a tricyclic lactam via Beckmann rearrangement and ring-rearrangement metathesis as key steps

Beilstein Journal of Organic Chemistry, 2015
A tricyclic lactam is reported in a four step synthesis sequence via Beckmann rearrangement and ring-rearrangement metathesis as key steps. Here, we used a simple starting material such as dicyclopentadiene.
Sambasivarao Kotha, Ongolu Ravikumar, Jadab Majhi   +2 more
doaj   +1 more source

Fast Solvent-free Alkylation of Amides and Lactams under Microwave Irradiation

Molecules, 1999
N-Substituted amides and lactams are rapidly N-alkylated under solvent-free phase-transfer catalytic conditions using microwaves.
Dariusz Bogdal
doaj   +1 more source

Fungal Lactamases: Their Occurrence and Function

Frontiers in Microbiology, 2017
Fungi are absorptive feeders and thus must colonize and ramify through their substrate to survive. In so doing they are in competition, particularly in the soil, with myriad microbes.
Minglu Gao, Anthony E. Glenn, Alex A. Blacutt, Scott E. Gold   +3 more
doaj   +1 more source

Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position

Frontiers in Chemistry, 2019
Mono- and disubstituted 4-CF3 β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.
Monika Skibińska, Monika Skibińska, Marcin Kaźmierczak, Marcin Kaźmierczak, Thierry Milcent, Tomasz Cytlak, Tomasz Cytlak, Henryk Koroniak, Benoit Crousse   +8 more
doaj   +1 more source

Ni-catalyzed carbamoylation of unactivated alkenes for stereoselective construction of six-membered lactams

Nature Communications, 2022
Six-membered chiral lactams are common structural motifs of pharmaceuticals. Here, the authors describe a nickel-catalyzed reductive carbamoylation of alkenes to form enantioenriched six-membered lactams.
Chenhuan Zhang, Xianqing Wu, Tingting Xia, Jingping Qu, Yifeng Chen   +4 more
doaj   +1 more source

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source

Isothiourea-catalyzed asymmetric synthesis of β-lactams and β-amino esters from arylacetic acid derivatives and N-sulfonylaldimines

, 2014
This work is supported by a Royal Society for a University Research Fellowship and the EPSRC and GSK (Case Award) as well as by the European Research Council under the European Unionʼs Seventh Framework Programme (FP7/2007-2013) (ERC Grant Agreement No ...
Prevet, Hugues, Shapland, Peter, Smith, Andrew D., Douglas, James, Smith, Siobhan R., Slawin, Alexandra M. Z.   +5 more
core   +1 more source