Results 21 to 30 of about 74,505 (292)

Ni-catalyzed carbamoylation of unactivated alkenes for stereoselective construction of six-membered lactams

Nature Communications, 2022
Six-membered chiral lactams are common structural motifs of pharmaceuticals. Here, the authors describe a nickel-catalyzed reductive carbamoylation of alkenes to form enantioenriched six-membered lactams.
Chenhuan Zhang, Xianqing Wu, Tingting Xia, Jingping Qu, Yifeng Chen   +4 more
doaj   +1 more source

A highly stereoselective oxidation and an easy one pot elimination methodology for 3-allyl-3-phenylthio-β-lactams

, 2021
A novel, facile, highly efficient and stereoselective protocol for the synthesis of cis-3-allyl-3-phenylsulfinyl-β-lactams and 3-allylidene-β-lactams from cis-3-allyl-3-phenylthio-β-lactams using Selectfluor both as an oxidizing agent and as an ...
Suvidha Pandey (11835468), Reshma Nagpal (6203189), Aarti Thakur (11835471), Shamsher S. Bari (3832459), Renu Thapar (6203192)   +4 more
core   +1 more source

p-Nitrophenyl carbonate promoted ring-opening reactions of DBU and DBN affording lactam carbamates

Beilstein Journal of Organic Chemistry, 2016
The amidine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and DBN (1,5-diazabicyclo[4.3.0]non-5-ene) display nucleophilic behaviour towards highly electrophilic p-nitrophenyl carbonate derivatives with ring opening of the bicyclic ring to form ...
Madhuri Vangala, Ganesh P Shinde
doaj   +1 more source

Facile synthesis of novel benzothiazolylpyrazolyl anchored 3-thio/seleno/chloro-β-lactams: Synthetic intermediates for novel 3-sulfenyl/sulfonyl, C-3 functionalized monocyclic and spirocyclic β-lactams

, 2018
Efficient synthesis of a new series of 3-phenyl/benzylthio-4-benzothiazolylpyrazolyl-β-lactams is described. Treatment of 2-phenylthio/benzylthioacetic acid with benzothiazolylpyrazolyl substituted Schiff’s bases furnished trans-β-lactams exclusively ...
Jitender Bhalla (4284292), Aman Bhalla (3832465), Shamsher S. Bari (3832459)   +2 more
core   +1 more source

Stereoselective Synthesis of Ezetimibe via Cross-Metathesis of Homoallylalcohols and α‑Methylidene-β-Lactams

, 2016
Ru-catalyzed cross-metathesis (CM) reaction between β-arylated α-methylidene-β-lactams and terminal olefins was developed. The CM reaction is effectively catalyzed with Hoveyda–Grubbs second-generation catalyst affording corresponding α-alkylidene-β-aryl-
Filip Hessler (544447), Nikola Topolovčan (2567920), Marek Humpl (2987811), Jan Veselý (1843195), Martin Kotora (544451), Jiří Tauchman (2079664), Jan Kretschmer (2987814), Ivana Císařová (1580947)   +7 more
core   +1 more source

Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast [version 1; peer review: 2 approved]

F1000Research, 2021
Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs.
Erika Rodríguez Cavallo, Darío Méndez Cuadro, Albeiro Marrugo Padilla, Johana Marquez   +3 more
doaj   +1 more source

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering

Frontiers in Catalysis
The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, followed ...
Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha   +7 more
doaj   +1 more source

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source

The synthesis of (±)-(1R,6R,7R)-2-azabicyclo[4.2.0]octan-7-ol

Журнал органічної та фармацевтичної хімії
An approach to the synthesis of (±)-(1R,6R,7R)-2-azabicyclo[4.2.0]octan-7-ol, a promising amino alcohol building block for drug discovery, has been described. The method is based on [2+2] the cycloaddition of tert-butyl vinyl ether and a ketene generated
Danylo A. Nosyk, Serhii Yu. Lukyanenko, Dmytro S. Granat, Oleksandr O. Yurchenko, Oleksandr O. Grygorenko   +4 more
doaj   +1 more source

Methyl isocyanide as a convertible functional group for the synthesis of spirocyclic oxindole γ-lactams via post-Ugi-4CR/transamidation/cyclization in a one-pot, three-step sequence

Beilstein Journal of Organic Chemistry, 2018
The synthesis of spiro[indoline-3,2'-pyrrole]-2,5'(1'H)-diones and spiro[indoline-3,2'-pyrrolidine]-2,5'-diones, via a post-Ugi-domino transamidation/cyclization sequential process, has been achieved in three sequential steps utilizing a one-pot reaction
Amarendar Reddy Maddirala, Peter R. Andreana   +1 more
doaj   +1 more source