Results 21 to 30 of about 123,258 (356)

PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance. [PDF]

, 2018
β-lactam antibiotics are excellent drugs for treatment of staphylococcal infections, due to their superior efficacy and safety compared to other drugs.
Chambers, Henry F, Chatterjee, Som S, da Costa, Thaina M, de Oliveira, Carolina R   +3 more
core   +3 more sources

Sonogashira/N-acyliminium ion aromatic π-cyclisation processes: access to tetra- and pentacyclic lactams [PDF]

, 2008
Application of the Sonogashira reaction of N-alkynylimides with 2-iodophenol or 2-iodo-N-tosylaniline affords 2-(N-alkylimino)-benzofurans and indoles in good yield.
Grigg, R., Sridharan, V., Sykes, D.A.
core   +1 more source

Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position

Frontiers in Chemistry, 2019
Mono- and disubstituted 4-CF3 β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.
Monika Skibińska, Monika Skibińska, Marcin Kaźmierczak, Marcin Kaźmierczak, Thierry Milcent, Tomasz Cytlak, Tomasz Cytlak, Henryk Koroniak, Benoit Crousse   +8 more
doaj   +1 more source

Ni-catalyzed carbamoylation of unactivated alkenes for stereoselective construction of six-membered lactams

Nature Communications, 2022
Six-membered chiral lactams are common structural motifs of pharmaceuticals. Here, the authors describe a nickel-catalyzed reductive carbamoylation of alkenes to form enantioenriched six-membered lactams.
Chenhuan Zhang, Xianqing Wu, Tingting Xia, Jingping Qu, Yifeng Chen   +4 more
doaj   +1 more source

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source

p-Nitrophenyl carbonate promoted ring-opening reactions of DBU and DBN affording lactam carbamates

Beilstein Journal of Organic Chemistry, 2016
The amidine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and DBN (1,5-diazabicyclo[4.3.0]non-5-ene) display nucleophilic behaviour towards highly electrophilic p-nitrophenyl carbonate derivatives with ring opening of the bicyclic ring to form ...
Madhuri Vangala, Ganesh P Shinde
doaj   +1 more source

Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast [version 1; peer review: 2 approved]

F1000Research, 2021
Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs.
Erika Rodríguez Cavallo, Darío Méndez Cuadro, Albeiro Marrugo Padilla, Johana Marquez   +3 more
doaj   +1 more source

The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria [PDF]

, 2008
Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
A Baslé, A Baslé, A Bryskier, A Davin-Regli, A Davin-Régli, A Doménech-Sánchez, A Doménech-Sánchez, A Loli, A Mena, A Mena, A Prilipov, A Thiolas, A Thiolas, AA Medeiros, AH Delcour, AM Berezhkovskii, AM Giuliodori, AS Low, C Bornet, C Bornet, C Bosi, C Danelon, C Danelon, C Rodrigues, C Sheridan, Chloë E. James, D Jeanteur, D Szabó, DJ Wolter, E Dé, E Elliott, E Sugawara, EM Nestorovich, EM Nestorovich, F Yoshimura, FM Kaczmarek, G Schwarz, GA Jacoby, GE Schulz, H Nikaido, H Nikaido, H Nikaido, H Samartzidou, H Samartzidou, J Bredin, J Chevalier, J Chevalier, J-M Pagès, JC Cai, Jean-Marie Pagès, JM Bower, K Poole, L Kullman, L Martínez-Martínez, LB Rice, LJ Piddock, LP Randall, M Ceccarelli, M Guillier, M Luckey, M Malléa, M Olesky, M Olesky, M Viveiros, MA Kohanski, Mathias Winterhalter, MM Ochs, N El Amin, P Valentin-Hansen, R Dutzler, R Iyer, R Iyer, R Koebnik, RE Hancock, RN Charrel, S Biswas, S Blot, S Hernández-Allés, S Hernández-Allés, S Nekolla, S Vidal, S Vidal, SF Epp, SM Bezrukov, SM Bezrukov, SR Norrby, SW Cowan, T Ferenci, T Mach, UO Hasdemir, V Simonet, V Simonet, WL Veal, WM Shafer, WR Bauer, XZ Li   +95 more
core   +1 more source

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering

Frontiers in Catalysis
The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, followed ...
Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha   +7 more
doaj   +1 more source

Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health [PDF]

, 2010
Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present
Butaye, Patrick, Dewulf, Jeroen, Haesebrouck, Freddy, Herman, Lieve, Heyndrickx, Marc, Martel, An, Persoons, Davy, Smet, Annemieke   +7 more
core   +1 more source