Results 21 to 30 of about 68,227 (310)

Conversion of Glucuronic Acid Glycosides to Novel Bicyclic β-Lactams

, 2016
Methodology for the conversion of glucuronic acid glycosides to novel bicyclic β-lactams is reported. Using this strategy, we prepared two novel templates suitable for use in combinatorial chemistry strategies for the construction of a number of ...
Timothy B. Durham (1698085), Marvin J. Miller (398964)   +1 more
core   +2 more sources

p-Nitrophenyl carbonate promoted ring-opening reactions of DBU and DBN affording lactam carbamates

Beilstein Journal of Organic Chemistry, 2016
The amidine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and DBN (1,5-diazabicyclo[4.3.0]non-5-ene) display nucleophilic behaviour towards highly electrophilic p-nitrophenyl carbonate derivatives with ring opening of the bicyclic ring to form ...
Madhuri Vangala, Ganesh P Shinde
doaj   +1 more source

Facile synthesis of novel benzothiazolylpyrazolyl anchored 3-thio/seleno/chloro-β-lactams: Synthetic intermediates for novel 3-sulfenyl/sulfonyl, C-3 functionalized monocyclic and spirocyclic β-lactams

, 2018
Efficient synthesis of a new series of 3-phenyl/benzylthio-4-benzothiazolylpyrazolyl-β-lactams is described. Treatment of 2-phenylthio/benzylthioacetic acid with benzothiazolylpyrazolyl substituted Schiff’s bases furnished trans-β-lactams exclusively ...
Jitender Bhalla (4284292), Aman Bhalla (3832465), Shamsher S. Bari (3832459)   +2 more
core   +1 more source

Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast [version 1; peer review: 2 approved]

F1000Research, 2021
Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs.
Erika Rodríguez Cavallo, Darío Méndez Cuadro, Albeiro Marrugo Padilla, Johana Marquez   +3 more
doaj   +1 more source

Consequences of avoiding β-lactams in patients with β-lactam allergies [PDF]

Journal of Allergy and Clinical Immunology, 2016
The choice of empiric antibiotics for the treatment of gram-negative bacilli (GNB) bloodstream infections (BSIs) in patients presenting with a β-lactam (BL) allergy is often a difficult decision given that these agents are first-line treatment in many guidelines.We sought to compare rates of clinical failure between patients with a history of BL ...
Meghan N, Jeffres, Prasanna P, Narayanan, Jerrica E, Shuster, Garrett E, Schramm   +3 more
openaire   +2 more sources

Stereoselective Synthesis of Ezetimibe via Cross-Metathesis of Homoallylalcohols and α‑Methylidene-β-Lactams

, 2016
Ru-catalyzed cross-metathesis (CM) reaction between β-arylated α-methylidene-β-lactams and terminal olefins was developed. The CM reaction is effectively catalyzed with Hoveyda–Grubbs second-generation catalyst affording corresponding α-alkylidene-β-aryl-
Filip Hessler (544447), Nikola Topolovčan (2567920), Marek Humpl (2987811), Jan Veselý (1843195), Martin Kotora (544451), Jiří Tauchman (2079664), Jan Kretschmer (2987814), Ivana Císařová (1580947)   +7 more
core   +1 more source

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Ronald H.B. Galt, Michael I. Page, Hadfield, Peter S., Page, Michael I., Peter S. Hadfield, Bartholomew Vilanova, Lorraine A. Casey, Galt, Ronald H.B., Casey, Lorraine A., Vilanova, Bartholomew, Galt, Ronald H. B.   +10 more
core   +1 more source

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering

Frontiers in Catalysis
The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, followed ...
Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha   +7 more
doaj   +1 more source

The synthesis of (±)-(1R,6R,7R)-2-azabicyclo[4.2.0]octan-7-ol

Журнал органічної та фармацевтичної хімії
An approach to the synthesis of (±)-(1R,6R,7R)-2-azabicyclo[4.2.0]octan-7-ol, a promising amino alcohol building block for drug discovery, has been described. The method is based on [2+2] the cycloaddition of tert-butyl vinyl ether and a ketene generated
Danylo A. Nosyk, Serhii Yu. Lukyanenko, Dmytro S. Granat, Oleksandr O. Yurchenko, Oleksandr O. Grygorenko   +4 more
doaj   +1 more source

Methyl isocyanide as a convertible functional group for the synthesis of spirocyclic oxindole γ-lactams via post-Ugi-4CR/transamidation/cyclization in a one-pot, three-step sequence

Beilstein Journal of Organic Chemistry, 2018
The synthesis of spiro[indoline-3,2'-pyrrole]-2,5'(1'H)-diones and spiro[indoline-3,2'-pyrrolidine]-2,5'-diones, via a post-Ugi-domino transamidation/cyclization sequential process, has been achieved in three sequential steps utilizing a one-pot reaction
Amarendar Reddy Maddirala, Peter R. Andreana   +1 more
doaj   +1 more source