Results 41 to 50 of about 68,227 (310)

Inversion of Stereochemistry in the Co₂(CO)₈-Catalyzed Carbonylation of Aziridines to β-Lactams. The First Synthesis of Highly Strained trans-Bicyclic β-Lactams

, 2016
β-Lactams were synthesized by the carbonylative ring expansion of aziridines catalyzed by dicobalt octacarbonyl under CO pressure. The active catalyst, cobalt tetracarbonyl anion, induces nucleophilic ring opening of the heterocycle, resulting in ...
Howard Alper (1528849), Marcelo E. Piotti (2995146)   +1 more
core   +2 more sources

Photoinduced Temperature-Regulated Selective Carbene C–H Insertion for the Synthesis of Functionalized Spiro-β-lactones and -lactams

, 2023
A temperature-regulated catalyst-free photoinduced selective carbene C–H insertion strategy was realized to efficiently synthesize spiro-β-lactones and -lactams, which hold considerable promise in drug discovery programs.
Durga Prasad Hari, Bhismalochan Ghorai, Abdur Rouf Samim Mondal, Bhismalochan Ghorai (16269898), Durga Prasad Hari (1344915), Abdur Rouf Samim Mondal (16269895)   +5 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Synthesis of Novel N-Sulfonyl Monocyclic β-Lactams as Potential Antibacterial Agents

Molecules, 2006
New cis monocyclic β-lactams were synthesized by [2+2] Staudinger cycloaddition reactions of the imine (3,4-dimethoxybenzylidene)-(4-methoxyphenyl)- amine and ketenes derived from different acyl chlorides and Et3N.
Maaroof Zarei, Aliasghar Jarrahpour
doaj   +1 more source

Microwave-induced Conversion of Electromagnetic Energy into Heat Energy in Different Solvents: Synthesis of β-lactams

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2021
In this work, the stereospecific synthesis of optically active cis β-lactams under diverse microwave-induced conditions using diverse solvents was reported.
Aparna Das, Ram Naresh Yadav, Bimal Krishna Banik   +2 more
doaj   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries

Angewandte Chemie, EarlyView.
This review explores how bidentate directing auxiliaries have advanced transition‐metal catalysis for unactivated alkene/alkyne functionalization. By leveraging chelated intermediates, bidentate directing auxiliaries enable precise hydrofunctionalization, difunctionalization, and C─H activation of π‐bonds with unique selectivity and reactivity.
Seunghyeon Cho, Al Vicente Riano D. Lisboa, Juntao Sun, Taeho Kang, Keary M. Engle   +4 more
wiley   +2 more sources

Biobased Lactams as Novel Arthropod Repellents

Natural Product Communications, 2014
Enanatiomerically pure 4a S ,7 S ,7a R and 4a S ,7 S ,7a S -nepetalactams and their analogs have been prepared in just two steps from 4a S ,7 S ,7a R and 4a S ,7 S ,7a S -nepetalactones, major components of catnip oil.
Kamlesh R. Chauhan, Hemant Khanna, Nagendra Babu Bathini, Thanh C. Le, John Grieco   +4 more
doaj   +1 more source

Enantioselective Total Syntheses of [6R,7R] and [6S,7S] Tricyclic β-Lactams

, 2016
The reaction of Ox-glycyl chloride with a chiral imine derived from the combination of d-(R)-glyceraldehyde acetonide and protected d-threonine afforded optically active, highly functionalized cis-substituted β-lactams 11 and 12.
Chuansheng Niu (3036279), Teresia Pettersson (3036276), Marvin J. Miller (398964)   +2 more
core   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source