Results 41 to 50 of about 74,505 (292)
Biobased Lactams as Novel Arthropod Repellents
Natural Product Communications, 2014 Enanatiomerically pure 4a S ,7 S ,7a R and 4a S ,7 S ,7a S -nepetalactams and their analogs have been prepared in just two steps from 4a S ,7 S ,7a R and 4a S ,7 S ,7a S -nepetalactones, major components of catnip oil.
Kamlesh R. Chauhan +4 more
doaj +1 more source
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2012 A new technique for the elaboration of α-methylene-γ-butyrolactams hydroxymethylated at the β-position has been developed. This new synthetic approach is based upon the preliminary assembly of N protected and γ-carboxylated analogues.
Gwenaëlle Liberge +3 more
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Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2021 In this work, the stereospecific synthesis of optically active cis β-lactams under diverse microwave-induced conditions using diverse solvents was reported.
Aparna Das +2 more
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Trifluoroethanol Promoted Castagnoli–Cushman Cycloadditions of Imines with Homophthalic Anhydride
Molecules, 2022 Lactams are essential compounds in medicinal chemistry and key intermediates in the synthesis of natural products. The Castagnoli–Cushman reaction (CCR) of homophthalic anhydride with imines is an exciting method for accessing cyclic densely substituted ...
Thibault Bayles, Catherine Guillou
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Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
Anodic Oxidation of Aliphatic and Aromatic Amides, Bisamides and Related Derivatives
ChemElectroChemThe current comprehensive review covers four main parts, of which some are presented in the form of a personal account. 1. Anodic oxidation of a) N‐alkyl and N,N‐diallyl carbonyl moieties, b) Azacycloalkyl amides and the effect of ring‐size on the ...
Prof. James Y. Becker
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Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams
Molecules, 2010 Because of their interesting biological properties various methods for the synthesis of substituted pyrroles are described in the literature. However, synthesis of pyrroles fused with a β-lactam ring has not been reported.
Bimal K. Banik +4 more
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Marine Drugs, 2023 The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria ...
Jed F. Fisher, Shahriar Mobashery
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Advanced Science, EarlyView.This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng +9 more
wiley +1 more source