Results 61 to 70 of about 68,227 (310)
Advanced Science, EarlyView.A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang +9 more
wiley +1 more source
Cell Reports, 2019 Summary: Whereas the primary actions of β-lactams are well characterized, their downstream effects are less well understood. Although their targets are extracellular, β-lactams stimulate respiration in Escherichia coli leading to increased intracellular ...
Loïc Léger +5 more
doaj +1 more source
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Photoredox approach to N-Acyl-N'-aryl-N,N'-aminals using enamides and their conversion to γ-lactams [PDF]
, 2018 A photoredox catalytic approach to synthetically valuable N-acyl-N'-aryl-N,N'-aminals is described. This method uses the addition of a radical precursor to enamides, with subsequent interception of the cationic iminium intermediate with an arylamine. The
Marc Kimber (1249593) +7 more
core +2 more sources
Eosin Y- and Copper-Catalyzed Dark Reaction To Construct Ene-γ-Lactams
, 2018 Eosin Y, a common organo-photocatalyst in visible-light photoredox processes, was found to show excellent catalytic activities for thermal redox reactions under a catalytic amount of Cu(OAc)2.
Kai-Wen Feng (4534645) +9 more
core +1 more source
Skeletal Metalation of Lactams through Carbonyl-to-Nickel Exchange Logic
, 2023 Classical metalation reactions such as the metal-halogen exchange are powerful tools to construct chemical bonds between two molecules. An analogous metal-carbon exchange strategy would provide a new entry into the direct structural remodeling of core ...
Patrick , Finkelstein +7 more
core +1 more source
Advanced Science, EarlyView.A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng +13 more
wiley +1 more source
A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones
Advanced Science, EarlyView.Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim +5 more
wiley +1 more source
Enantioselective Synthesis of Alkaloids from Phenylglycinol-Derived Lactams
Natural Product Communications, 2011 This review is focused on recent synthetic achievements and ongoing work in our laboratory using phenylglycinol-derived oxazolopiperidone lactams as starting materials for the enantioselective synthesis of piperidine-containing alkaloids: madangamines, 2,
Mercedes Amat +4 more
doaj +1 more source
New Microbes and New Infections, 2019 We report a case of hospital-acquired pneumonia that to our knowledge is the first description in Egypt of the emergence of vancomycin (VA)-resistant Staphylococcus aureus due to the concomitant use of β-lactams.
A.E. Taha +3 more
doaj +1 more source