Results 61 to 70 of about 74,505 (292)
Ynolate Chemistry. Reaction of a Silylynolate with Aziridines Leading to γ-Lactams
, 2016 A silylynolate, generated via the carbonylation of lithium silyldiazomethane, was reacted with N-tosyl aziridines to produce various five-membered lactams in good yields.
Naoto Chatani (1364754) +3 more
core +1 more source
Skeletal Metalation of Lactams through Carbonyl-to-Nickel Exchange Logic [PDF]
, 2023 Classical metalation reactions such as the metal-halogen exchange are powerful tools to construct chemical bonds between two molecules. An analogous metal-carbon exchange strategy would provide a new entry into the direct structural remodeling of core ...
Patrick , Finkelstein +7 more
core +2 more sources
Advanced Science, EarlyView.Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao +6 more
wiley +1 more source
, 2016 β-Lactams were synthesized by the carbonylative ring expansion of aziridines catalyzed by dicobalt octacarbonyl under CO pressure. The active catalyst, cobalt tetracarbonyl anion, induces nucleophilic ring opening of the heterocycle, resulting in ...
Howard Alper (1528849) +1 more
core +2 more sources
Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
Angewandte Chemie, EarlyView.The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +2 more sources
Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation
Angewandte Chemie, EarlyView.The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam +5 more
wiley +2 more sources
Comparison of combination therapy with beta-lactam and aminoglycoside antibiotics versus monotherapy with beta-lactam antibiotics on clinical outcomes in adult sepsis patients at RSUP Dr. Kariadi in Semarang [PDF]
BIO Web of ConferencesSepsis is a complex clinical syndrome resulting from the body’s systemic response to an infection that causes organ dysfunction and requires treatment with broad-spectrum antibiotics. Beta-lactams are broad-spectrum antibiotics used either as monotherapy
Dilaga Arroyani Asa +3 more
doaj +1 more source
Enantioselective Total Syntheses of [6R,7R] and [6S,7S] Tricyclic β-Lactams
, 2016 The reaction of Ox-glycyl chloride with a chiral imine derived from the combination of d-(R)-glyceraldehyde acetonide and protected d-threonine afforded optically active, highly functionalized cis-substituted β-lactams 11 and 12.
Chuansheng Niu (3036279) +2 more
core +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
A copper-catalyzed enantioconvergent radical C(sp3)–N cross-coupling of racemic tertiary α-bromo-β-lactams with aromatic amines is developed under mild thermal reaction conditions.
Wei-Long Liu (2413084) +5 more
core +2 more sources