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Distinct Clinical Phenotypes in Lactase Nonpersistence: Symptomatic, Asymptomatic, and Gassy-Asymptomatic. [PDF]

open access: yesAm J Gastroenterol
Azimov M   +5 more
europepmc   +1 more source

Frequency and Diagnostic Utility of the -13910C>T <i>MCM6</i> Gene Polymorphism for Lactose Intolerance in a Brazilian Northeast Population. [PDF]

open access: yesIn Vivo
DE Morais GP   +10 more
europepmc   +1 more source

Preterm Birth International Collaborative Australasia Branch: Expert Consensus on Diagnosis and Treatment of Neonatal Lactose Intolerance (2025). [PDF]

open access: yesPediatr Discov
Wang Z   +42 more
europepmc   +1 more source
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On the Evolution of Lactase Persistence in Humans

Annual Review of Genomics and Human Genetics, 2017
Lactase persistence—the ability of adults to digest the lactose in milk—varies widely in frequency across human populations. This trait represents an adaptation to the domestication of dairying animals and the subsequent consumption of their milk. Five variants are currently known to underlie this phenotype, which is monogenic in Eurasia but mostly ...
Laure Segurel, Celine Bon
exaly   +4 more sources

Lactase Non-persistence and Lactose Intolerance

Current Gastroenterology Reports, 2017
To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence.
Theodore M Bayless   +2 more
exaly   +3 more sources

Human lactase and the molecular basis of lactase persistence

Biochemical Genetics, 1985
Human lactase purified from detergent extracts of the total membrane fraction of postmortem jejunum by means of monoclonal immunoadsorbent chromatography appears to be a dimer of subunits identical in Mr (160K). Trypsin or papain removes a small hydrophobic anchoring peptide from each subunit to give a hydrophilic enzyme which no longer interacts with ...
J, Potter   +5 more
openaire   +2 more sources

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