Distinct Clinical Phenotypes in Lactase Nonpersistence: Symptomatic, Asymptomatic, and Gassy-Asymptomatic. [PDF]
Azimov M +5 more
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Mechanistic Insights into Multiherb Formulations for Antibiotic-Associated Diarrhea: A Systematic Review of Preclinical Studies on Microbiome-Host Interactions. [PDF]
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Frequency and Diagnostic Utility of the -13910C>T <i>MCM6</i> Gene Polymorphism for Lactose Intolerance in a Brazilian Northeast Population. [PDF]
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Preterm Birth International Collaborative Australasia Branch: Expert Consensus on Diagnosis and Treatment of Neonatal Lactose Intolerance (2025). [PDF]
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Lactase restriction and lactase persistence: a study of sri lankans and a paediatric population
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On the Evolution of Lactase Persistence in Humans
Annual Review of Genomics and Human Genetics, 2017Lactase persistence—the ability of adults to digest the lactose in milk—varies widely in frequency across human populations. This trait represents an adaptation to the domestication of dairying animals and the subsequent consumption of their milk. Five variants are currently known to underlie this phenotype, which is monogenic in Eurasia but mostly ...
Laure Segurel, Celine Bon
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Lactase Non-persistence and Lactose Intolerance
Current Gastroenterology Reports, 2017To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence.
Theodore M Bayless +2 more
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Human lactase and the molecular basis of lactase persistence
Biochemical Genetics, 1985Human lactase purified from detergent extracts of the total membrane fraction of postmortem jejunum by means of monoclonal immunoadsorbent chromatography appears to be a dimer of subunits identical in Mr (160K). Trypsin or papain removes a small hydrophobic anchoring peptide from each subunit to give a hydrophilic enzyme which no longer interacts with ...
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