Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase [PDF]
J Theor Biol 240: 464-474 (2006), 2005 Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson +47 more
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Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]
Scientific Reports 5, 11880 (2015), 2015 Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production.
CAPUANI, FABRIZIO +3 more
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Prediction of Blood Lactate Values in Critically Ill Patients: A Retrospective Multi-center Cohort Study [PDF]
J Clin Monit Comput. 2021 PMID: 34224051, 2021 Purpose. Elevations in initially obtained serum lactate levels are strong predictors of mortality in critically ill patients. Identifying patients whose serum lactate levels are more likely to increase can alert physicians to intensify care and guide them in the frequency of tending the blood test.
arxiv +1 more source
Blood lactate clearance during active recovery after an intense running bout depends on the intensity of the active recovery [PDF]
, 2010 High-intensity exercise training contributes to the production and accumulation of blood lactate, which is cleared by active recovery. However, there is no commonly agreed intensity or mode for clearing accumulated blood lactate.
Kemi, O.J. +5 more
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Frontiers in Physiology, 2020 This study compared the acute physiological responses of traditional and practical blood flow restriction resistance exercise (tBFR and pBFR, respectively) and high- and low-load resistance exercise without BFR (HL and LL, respectively), as well as the ...
Eduardo D. S. Freitas +7 more
doaj +1 more source
Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. [PDF]
, 2015 We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer ...
Brooks, George A +6 more
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Frontiers in Nutrition, 2022 Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanisms of brain ...
Ming Cai +8 more
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Direct and indirect lactate oxidation in trained and untrained men. [PDF]
, 2013 Lactate has been shown to be an important oxidative fuel. We aimed to quantify the total lactate oxidation rate (Rox) and its direct vs. indirect (glucose that is gluconeogenically derived from lactate and subsequently oxidized) components (mg·kg(-1)·min(
Brooks, George A +5 more
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Acute Spinal Cord Injury: Correlations and Causal Relations Between Intraspinal Pressure, Spinal Cord Perfusion Pressure, Lactate-to-Pyruvate Ratio, and Limb Power. [PDF]
, 2021 BACKGROUND/OBJECTIVE: We have recently developed monitoring from the injury site in patients with acute, severe traumatic spinal cord injuries to facilitate their management in the intensive care unit.
Hogg, FRA +4 more
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Frontiers in Oncology, 2018 The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix ...
Alexandre Morrot +10 more
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