Journal of Dairy Science, 2022 : Supplemental n-3 fatty acids (FA) may support better immune responses than n-6 and n-9 FA in dairy calves. The objective was to evaluate the effect of n-3 FA, supplemented as a fish oil product (FO) in the milk replacer (MR), in comparison to n-6 and n-
P. Melendez +8 more
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Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production [PDF]
, 2017 Many high-value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimise the productivity of these cultures it is important to monitor cellular metabolism, for example the utilisation
Ainsworth, C +5 more
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Insulin gene expression and functional activity of insulin signaling pathway in Alzheimer's disease
Фундаментальная и клиническая медицина, 2021 Aim. To study the insulin (INS) gene expression, insulin and lactate levels, expression of Fe65 adapter protein, and level of oxidative DNA damage marker γH2AX in different brain areas in the experimental model of Alzheimer's disease.Materials and ...
Y. V. Gorina +4 more
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Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital. [PDF]
, 2011 BACKGROUND: Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its ...
Acierno +22 more
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Role of Lactate in Inflammatory Processes: Friend or Foe
Frontiers in Immunology, 2022 During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in ...
Carolina Manosalva +8 more
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Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation [PDF]
, 2018 Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Mennerick, Steven +3 more
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Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window [PDF]
Journal of Exercise & Organ Cross TalkDear Editor-in-ChiefWith the alarming rise in cancer cases, which is now recognized as the leading cause of death, the importance of exercise in cancer management is gaining significant recognition (Ahmadi Hekmatikar et al., 2023).
Amir Hossein Ahmadi Hekmatikar +2 more
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ROL Spor Bilimleri Dergisi, 2023 This study, it was aimed to compare the effects of acute squat exercise applied to the lower extremities with and without blood flow restriction (BFR) on post-exercise cardiovascular responses, blood lactate level and perceived exercise intensity.
Seda Yalcin
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TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]
, 2016 A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon +15 more
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Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. [PDF]
, 2015 We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer ...
Brooks, George A +6 more
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