Results 11 to 20 of about 980,886 (403)
Cell Death and Differentiation, 2021 High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Kun Yang +10 more
semanticscholar +1 more source
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes‐Associated Breast Cancer
Advanced Science, 2022 Diabetes is directly related to the risk of breast cancer (BC) occurrence and worsened BC prognosis. Currently, there are no specific treatments for diabetes‐associated BC.
Qiongyu Hao +13 more
doaj +1 more source
Analysis of lactation shapes in extended lactations [PDF]
animal, 2012 In order to describe the temporal evolution of milk yield (MY) and composition in extended lactations, 21 658 lactations of Italian Holstein cows were analyzed. Six empirical mathematical models currently used to fit 305 standard lactations (Wood, Wilmink, Legendre, Ali and Schaeffer, quadratic and cubic splines) and one function developed specifically
Roberto Steri +4 more
openaire +4 more sources
Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
International Journal of Molecular Sciences, 2022 Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen +5 more
semanticscholar +1 more source
European Journal of Translational Myology, 2021 In Multiple sclerosis (MS) it is important to preserve the residual physiological functions of subjects. The aim of the present study was to investigate the influence of nanotechnological device treatment combined with home-based training program (TP) on
Alessandra Amato +8 more
doaj +1 more source
Role of Lactate in Inflammatory Processes: Friend or Foe
Frontiers in Immunology, 2022 During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in ...
C. Manosalva +6 more
semanticscholar +1 more source
Mutual regulation of lactate dehydrogenase and redox robustness
Frontiers in Physiology, 2022 The nature of redox is electron transfer; in this way, energy metabolism brings redox stress. Lactate production is associated with NAD regeneration, which is now recognized to play a role in maintaining redox homeostasis.
Yijun Lin, Yan Wang, Pei-feng Li
doaj +1 more source
eLife, 2022 Lack of oxygen (hypoxia and anoxia) is detrimental to cell function and survival and underlies many disease conditions. Hence, metazoans have evolved mechanisms to adapt to low oxygen.
Jong S Park +11 more
doaj +1 more source
Inflammation, 2022 Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of anaerobic glycolysis with end product of lactate from glucose. The lactate formation is crucial in the metabolism of glucose when oxygen is in inadequate supply.
G. Gupta
semanticscholar +1 more source
Bcl-3 regulates the function of Th17 cells through raptor mediated glycolysis metabolism
Frontiers in Immunology, 2022 Bcl-3 is an atypical IκB family member that regulates transcription in the nucleus by binding to the p50/p52 homologous dimer subunit. Although various studies illustrate the important role of Bcl-3 in physiological function, its role in metabolism is ...
Hui Liu +8 more
doaj +1 more source